Abstract
Nail involvement occurs in up to 50 % of patients with psoriasis. Although most patients experience concurrent skin involvement, 1–5 % of patients present with nail changes alone. In these patients, it can be diagnostically challenging, as psoriatic nail disease can resemble several other nail dystrophies.
In this chapter, we describe the differential diagnoses for each classic signs of nail psoriasis including pitting, onycholysis, subungual hyperkeratosis, splinter hemorrhages, and oil spots.
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FormalPara Key Features-
Several diseases can cause nail abnormalities similar to those in nail psoriasis. The most important differential diagnoses include alopecia areata, idiopathic onycholysis, and traumatic nail disorders.
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A diagnosis of onychomycosis does not exclude nail psoriasis as the two conditions are commonly associated.
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A good history is invaluable in determining the correct diagnosis.
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Exam of all 20 nails is always necessary.
11.1 Introduction
Nail involvement occurs in up to 50 % of patients with psoriasis [1]. Although most patients experience concurrent skin involvement, 1–5 % of patients present with nail changes alone [2]. In these patients, it can be diagnostically challenging, as psoriatic nail disease can resemble several other nail dystrophies.
In this chapter, we describe the differential diagnoses for each classic sign of nail psoriasis including pitting, onycholysis, subungual hyperkeratosis, splinter hemorrhages, and oil spots [3].
11.2 Nail Plate Pitting
Common causes of nail pitting include psoriasis, alopecia areata, and eczema. A few pits can also be seen in normal nails. Uncommon causes include parakeratosis pustulosa, pemphigus vulgaris, sarcoidosis, dermatomyositis, drug-induced erythroderma, secondary syphilis, Reiter’s disease, chronic renal failure/hemodialysis, and chronic paronychia [4] (Table 11.1).
Certain characteristics of nail pitting can help to identify its etiology (Table 11.2). Psoriatic pits are typically deep, indicating involvement of the intermediate and ventral nail plate [5]. Moreover, presence of more than 20 pits is suggestive of psoriatic nail disease [6]. Over 60 pits has been said to be diagnostic of psoriasis [7]. In contrast, pits in alopecia areata are small, superficial and usually arranged in a regularly distributed geometric pattern [8] (Fig. 11.1). They may demonstrate a “rippled” effect [9] and run along longitudinal or transverse lines [8]. Other nail signs of alopecia areata include mottled erythema of the lunula, onychomadesis, and trachyonychia [6, 10]. Pits in eczema are coarse, very irregular and associated with cross ridging [8] The term elkonyxis describes a very large irregular depression, which can be seen in syphilis, Reiter’s disease, following a traumatic event, or after isotretinoin therapy [6, 11]. Small pitted craters on the middle and ring fingers, known as Rosenaus depressions, are characteristically seen in patients with diabetes mellitus [12]. It is important to remember that an isolated pit is not diagnostic and may be idiopathic in nature [9].
11.3 Onycholysis
The differential diagnosis for onycholysis depends on its location (Table 11.3). The most common cause of onycholysis in fingernails is idiopathic onycholysis (Fig. 11.2). More common in women, idiopathic onycholysis has been speculated to arise secondary to the same environmental factors that result in chronic paronychia [4]. Frequent wetting, irritant contact, or aggressive manicure can damage the onychocorneal band, resulting in nail plate detachment [13]. The onycholytic space is frequently colonized by bacteria and yeast, including Pseudomonas, causing a typical green discoloration (Fig. 11.3). Irregularly sculpted onycholysis (“rollercoaster onycholysis”) may be an indication of overzealous manicuring [9] and is often associated with striate leukonychia [14] (Fig. 11.4). Occupational onycholysis is seen in hairdressers and butchers.
Psoriatic nail onycholysis may be distinguished by the presence of an erythematous rim surrounding the area of onycholysis [3], a finding almost exclusively seen in the fingernails. Moreover, Dawber et al. found that the rate of growth of normal fingernails can help discriminate psoriatic nail versus idiopathic onycholysis. While they described a faster growth rate in nails affected by both psoriatic and idiopathic onycholysis, they found a slightly slower than normal growth rate in the normal nails of idiopathic onycholysis as compared to the normal nails in psoriasis [15].
Other dermatologic conditions causing onycholysis, with a predilection for the fingernails, include eczematous dermatitis and lichen planus. In lichen planus, onycholysis is usually associated with onychorrhexis and other signs of nail matrix involvement (Fig. 11.5). Pompholyx can cause very distal onycholysis affecting most digits [14].
The two main causes of onycholysis in the toenails are trauma and onychomycosis [9]. Toe stubbing and ill-fitting shoes can lead to nail plate detachment [14]. Onycholysis of the great toe due to an overriding second toe is common and involves the lateral side of the nail [9] (Fig. 11.6). The presence of hemorrhage is a clue for a traumatic cause [16].
Differentiating distal subungual onychomycosis from psoriasis is especially challenging in the toenails. Onychomycosis can be distinguished by the presence of other nail findings, particularly yellow patches and strikes (Fig. 11.7). It is important to consider the possible coexistence of both diseases, which was reported to occur in 48 % of patients [3, 17]. The concomitant conditions are thought to exacerbate each other, as well. While nail psoriasis itself has been deemed a risk factor for developing onychomycosis [18], Kacar et al. observed more severe nail changes in patients with onychomycosis and suggested the possibility of worsening nail psoriasis by fungal infection via Koebnerization [19]. Ultimately, a fungal and/or bacterial culture in addition to nail plate PAS should be obtained to rule out an infectious etiology [16].
Another cause of toenail onycholysis includes congenital malalignment of the big toenail in children [9].
Drugs can cause onycholysis and less frequently photo-onycholysis. Painful hemorrhagic onycholysis is a common side effect of treatment with taxanes, particularly docetaxel (Fig. 11.8). It is associated with subungual abscesses and usually involves several or all nails. The pathogenesis may be due to direct nail bed toxicity or disruption of nail bed angiogenesis. This complication can increase the risk of sepsis and may require treatment interruption [20].
Photo-onycholysis is rare and most commonly seen with psoralens and tetracycline use [16]. The onycholytic area demonstrates a characteristic hemorrhagic hue [14]. Most nails are affected but the thumbs are usually spared. There are four different subtypes of drug-induced photo-onycholysis: (1) the separation of the nail plate affects several nails and is concave distally with well-demarcated pigmentation proximally, (2) involving a single digit – well-demarcated, circular notch with the widest part distally and brownish pigmentation proximally, (3) round yellow staining (and later reddish) in the center of the nail bed with no lateral or distal margin involvement and affecting several digits, and (4) subungual bullae reported secondary to tetracycline hydrochloride use [9, 21].
Tetracycline or psoralen-induced photo-onycholysis can be painful [4]. Photo-onycholysis may also be observed as part of Segal’s triad – photosensitivity, onycholysis, and nail dyschromia [9, 22].
Metabolic disorders, particularly hyperthyroidism, have been reported to cause onycholysis. Plummer nail, a type of onycholysis in which the distal end of the nail curves upward and is undulated, is characteristic of thyrotoxicosis [23].
Onycholysis limited to one nail requires the exclusion of a subungual tumor as the cause. Tumors that can cause onycholysis include subungual exostoses, subungual fibromas, squamous cell carcinomas, and even melanoma [14] (Fig. 11.9). Radiography and/or biopsy is important for diagnosis [16].
Other uncommon causes of onycholysis include lichen striatus, sarcoidosis, and blistering diseases [16, 24].
11.4 Subungual Hyperkeratosis
Subungual hyperkeratosis is most commonly found in nail psoriasis or onychomycosis, although it may also be seen in eczema (Fig. 11.10), lichen planus, pityriasis rubra pilaris, and even cutaneous T cell lymphomas [9, 16]. Usually subungual hyperkeratosis is found in conjunction with onycholysis [9]. The nail bed hyperkeratosis seen in psoriasis is usually silvery white in colour. In onychomycosis, hyperkeratosis is usually seen with longitudinal streaks, indicating the pattern of fungal invasion [25]. Contact dermatitis of the nail bed may also result in subungual hyperkeratosis; however, this most frequently involves the first three digits in the dominant hand [25]. In pityriasis rubra pilaris and/or lichen planus, other cutaneous or nail findings may suggest the diagnosis [25] (Fig. 11.11).
11.5 Splinter Hemorrhages
Several conditions, other than psoriasis, may cause distal splinter hemorrhages. The most common is trauma (Fig. 11.12); other acute traumatic sequelae may include subungual hematomas and nail shedding [26]. Distal splinter hemorrhages can also be found in onychomycosis and eczema [16].
Proximal splinters are very rare and may be indicative of systemic disorders, including infective endocarditis, renal or pulmonary disease, diabetes mellitus, vasculitis, and antiphospholipid syndrome [27–30]. Pain can help distinguish a systemic etiology, but may not be consistently present [31]. Cholesterol crystal embolization has also been reported in a patient with splinter hemorrhages of multiple finger and toenails [32]. Hemodialysis and peritoneal dialysis have also been identified as causes of splinter haemorrhages, with peritoneal dialysis reported as the most frequent factor in a cohort of patients with splinter hemorrhages [29, 33, 34].
Drug-induced splinter hemorrhages in conjunction with onycholysis have also been reported after tetracycline use [35].
Splinter hemorrhages can also be found in healthy individuals, more frequently in males [27, 36]. When seen in females, they are often limited to a single digit [36–38]. Additionally, splinter hemorrhages are frequently seen in elderly patients who are more susceptible to nail damage.
11.6 Other Findings
Other nail findings, such as the “oil-drop sign” and red spots in the lunula, are more specific for psoriatic nail disease and can be used to help distinguish psoriasis from other dermatoses [39, 40]. This discoloration, along with pitting and nail plate crumbling, is virtually diagnostic of psoriasis [41].
Summary for the Clinician
The differential diagnosis of nail psoriasis includes nail abnormalities caused by traumatic, dermatological, and systemic disorders. Onychomycosis is more common in psoriatic nails and a diagnosis of onychomycosis does not exclude psoriasis.
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Yin, N.C., Tosti, A. (2014). Differential Diagnosis for Nail Psoriasis. In: Rigopoulos, D., Tosti, A. (eds) Nail Psoriasis. Springer, Cham. https://doi.org/10.1007/978-3-319-08810-5_11
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