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Enhancing Tablet Manufacturing Efficiency Through Numerical Simulation and Modeling of Pharmaceutical Powder Compaction: A Comprehensive Review

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International Conference on Advanced Intelligent Systems for Sustainable Development (AI2SD’2023) (AI2SD 2023)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 904))

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Abstract

Pharmaceutical powder compaction is a crucial process in tablet production that offers numerous benefits, including efficient production, consistency, cost-effectiveness, and enhanced tablet properties. It also has some limitations that must be considered. One limitation is that the compaction process can lead to the formation of defects in the tablets, such as cracks, splits, or capping, which can affect the mechanical strength, dissolution rate, and stability of the tablet. The use of numerical simulation can be relied upon to identify and fix these limitations by providing a cost-effective and efficient means of optimizing the compaction process and predicting the quality and properties of the final product. Tablet production involves various factors specific to the powders used, such as their coefficient of friction, mechanical behavior, and modulus of elasticity. Die compaction of the powder mixture causes a decrease in volume due to elastic and plastic deformations sustained by the particles. Elasto-plastic behavior is the most commonly considered densification mechanism. Numerical simulation plays a significant role in optimizing the manufacturing process. There are two main approaches to modelling compact compression: discrete and continuous. Several simulation models have been developed using both approaches. This article introduces the various modelling methods developed so far, highlighting their principles, approaches, advantages, and limitations to provide a solid starting point for researchers in the field.

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References

  1. Toussaint, F.: Etude expérimentale et simulation numérique de la mise en forme par compression et frittage de poudres, PhD Thesis, Institut National Polytechnique de Grenoble-INPG (2001)

    Google Scholar 

  2. Kadiri,M.S.: Compression de poudres pharmaceutiques et interaction avec l’outillage. Analyse expérimentale et modélisation numérique, PhD Thesis (2004)

    Google Scholar 

  3. Serris, E.: Influence des conditions de compression sur les propriétés physico- chimiques des comprimés issus de poudres organiques, p. 238, août (2006)

    Google Scholar 

  4. Jerier,J.-F.: Modélisation de la compression haute densité des poudres métalliques ductiles par la méthode des éléments discrets, PhD Thesis, Université Joseph-Fourier-Grenoble I (2009)

    Google Scholar 

  5. Abdelmoula,N.: Comportement élasto-plastique incrémental des poudres ductiles: simulation de l’écoulement plastique par la méthode des éléments finis multi- particules, PhD Thesis, Université Grenoble Alpes (2016)

    Google Scholar 

  6. Croquelois,B.: Comportement à rupture des matériaux hétérogènes fragiles: application au comprimé pharmaceutique, p. 157, déc 2020

    Google Scholar 

  7. Desbois,L.: Comportement mécanique des poudres et comprimés pharmaceutiques en compression: dépendance à la vitesse de deformation, PhD Thesis, Bordeaux (2021)

    Google Scholar 

  8. Tita-Goldstein,A.: Mise en forme des poudres par compression: influence du procédé et de la formulation pour la maitrise des propriétés d’usage, p. 143 (2013)

    Google Scholar 

  9. Vo, M.: Les comprimés, une forme d’avenir ? p. 198, sept. 2015

    Google Scholar 

  10. Saint-Raymond,O.: Étude de l’influence de la texture et de la structure des produits pharmaceutiques sur leur comprimabilité, p. 263 (1995)

    Google Scholar 

  11. Bounoua,A.: Structure, rhéologie et compressibilité de mélanges de poudres métalliques et céramiques & analyse structurale d’empilements 2D de sphères dures mono et polydispersés, PhD Thesis, Poitiers (1995)

    Google Scholar 

  12. Meziani,H.: Elaboration d’un composite W/Cu par infiltration, PhD Thesis, Université Mouloud Mammeri (2013)

    Google Scholar 

  13. Salençon,J.: De l’élasto-plasticité au calcul à la rupture. Editions Ecole Polytechnique (2002)

    Google Scholar 

  14. Harthong,B.: Modélisation du comportement des poudres métalliques à l’échelle du grain, p. 149

    Google Scholar 

  15. Taylor,G.I., et al.: The plastic distortion of metals. Philos. Trans. R. Soc. Lond. Ser. Contain. Pap. Math. Phys. Character 230(681‑693), 323‑362 (1931)

    Google Scholar 

  16. Prager,W., et al.: Problèmes de plasticité théorique. Dunod (1958)

    Google Scholar 

  17. Hraïri,M.: Modélisation numérique et identification directe et inverse du comportement des poudres métalliques lors du procédé du compactage. National Library of Canada = Bibliothèque nationale du Canada, Ottawa (2001)

    Google Scholar 

  18. Benabbes,A.: Approches micromécaniques de la compaction de poudres et de la rupture ductile des matériaux incluant le 3me invariant des contraintes, PhD Thesis, Thèse de Doctorat d’Etat, Université de Reims Champagne Ardenne École (2009)

    Google Scholar 

  19. Caramigeas,E.: Compression de matériaux pharmaceutiques: influence de la technologie conséquences sur la dissolution, PhD Thesis (1999)

    Google Scholar 

  20. Boussaoud,B.: Diagnostic en génie pharmaceutique (2003)

    Google Scholar 

  21. Aydin, I., et al.: The internal form of compacted ceramic components: a comparison of a finite element modelling with experiment. Powder Technol. 89(3), 239–254 (1996)

    Article  Google Scholar 

  22. Aydin, I., et al.: Dimensional variation of die-pressed ceramic green compacts: comparison of a finite element modelling with experiment. J. Eur. Ceram. Soc. 17(10), 1201–1212 (1997)

    Article  Google Scholar 

  23. Zipse, H.: Finite-element simulation of the die pressing and sintering of a ceramic component. J. Eur. Ceram. Soc. 17(14), 1707–1713 (1997)

    Article  Google Scholar 

  24. Dhatt,G., et al.: Une présentation de la méthode des éléments finis. Presses Université Laval (1981)

    Google Scholar 

  25. Batoz,J.-L., et al.: Modélisation des structures par éléments finis. Presses Université Laval (1990)

    Google Scholar 

  26. Dhatt,G., et al.: Méthode des éléments finis. Lavoisier (2005)

    Google Scholar 

  27. Oudin,H.: Méthode des éléments finis, PhD Thesis, Ecole Centrale de Nantes (ECN) (2008)

    Google Scholar 

  28. Ciarlet,P., et al.: La méthode des éléments finis: De la théorie à la pratique. ISTE Group (2022)

    Google Scholar 

  29. Duflot,M.: Applications des méthodes sans maillage en mécanique de la rupture, PhD Thesis, Université de Liege (2005)

    Google Scholar 

  30. Jensen, R.P., et al.: DEM simulation of particle damage in granular media—structure interfaces. Int. J. Geomech. 1(1), 21–39 (2001)

    Article  Google Scholar 

  31. Nicola,D.: Modélisation du comportement des poudres métalliques lors du pressage. École Polytechnique de Montréal (2003)

    Google Scholar 

  32. Calvetti, F., et al.: A numerical investigation of the incremental behavior of granular soils. Riv. Ital. Geotec. 37(3), 11–29 (2003)

    Google Scholar 

  33. Filali,M.: Conductivité thermique apparente des milieux granulaires soumis à des contraintes mécaniques: modélisation et mesures, PhD Thesis (2006)

    Google Scholar 

  34. Chazallon: Modélisation discrète en mécanique de la rupture des matériaux fragiles, PhD Thesis, Strasbourg (2013)

    Google Scholar 

  35. Storåkers, B., et al.: Similarity analysis of inelastic contact. Int. J. Solids Struct. 34(24), 3061–3083 (1997)

    Article  MathSciNet  Google Scholar 

  36. Potyondy, D.O., et al.: A bonded-particle model for rock. Int. J. Rock Mech. Min. Sci. 41(8), 1329–1364 (2004)

    Article  Google Scholar 

  37. Pöschel, T., et al.: Computational Granular Dynamics: Models and Algorithms. Springer Science & Business Media, Cham (2005)

    Google Scholar 

  38. Ransing, R.S., et al.: Powder compaction modelling via the discrete and finite element method. Mater. Des. 21(4), 263–269 (2000)

    Article  Google Scholar 

  39. Mesarovic, S.D., et al.: Frictionless indentation of dissimilar elastic– plastic spheres. Int. J. Solids Struct. 37(46–47), 7071–7091 (2000)

    Article  Google Scholar 

  40. Gethin, D.T., et al.: Numerical comparison of a deformable discrete element model and an equivalent continuum analysis for the compaction of ductile porous material. Comput. Struct. 79(13), 1287–1294 (2001)

    Article  Google Scholar 

  41. Yvonnet,J.: Nouvelles approches sans maillage basées sur la méthode des éléments naturels pour la simulation numérique des procédés de mise en forme (2006)

    Google Scholar 

  42. Hamrani,A.: Apports d’approches sans maillage pour la simulation des phénomènes de séparation de la matière. Application aux procédés de mise en forme. PhD Thesis, Paris, ENSAM (2016)

    Google Scholar 

  43. Hérault,C.: VERS UNE SIMULATION SANS MAILLAGE DES PHÉNOMÈNES ÉLECTROMAGNÉTIQUES, p. 139 (2012)

    Google Scholar 

  44. Yvonnet,J., et al.: Nouvelles avancées dans les méthodes sans maillage basées sur les éléments naturels contraints pour la simulation des procédés, p. 50 (2018)

    Google Scholar 

  45. Kadiri, M.S., Michrafy, A.: The effect of punch’s shape on die compaction of pharmaceutical powders. Powder Technol. 239, 467–477 (2013). https://doi.org/10.1016/j.powtec.2013.02.022

    Article  Google Scholar 

  46. Alfaro, I., Yvonnet, J., Cueto, E., Chinesta, F., Villon, P., Doblaré, M.: Méthodes sans maillage de type éléments naturels pour la simulation des procédés de mise en forme. Eur. J. Comput. Mech. Eur. Mécanique Numér. 15(1–3), 29–40 (2006)

    Article  Google Scholar 

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Authors and Affiliations

  1. IPIM Laboratory, ENSA Khouribga, Sultan Moulay Slimane University, Beni Mellal, Morocco

    S. Ramli & M. S. Kadiri

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  1. S. Ramli
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  2. M. S. Kadiri
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Correspondence to S. Ramli .

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Editors and Affiliations

  1. Computer Sciences Department, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaâdi University, Tangier, Morocco

    Mostafa Ezziyyani

  2. Systems Research Institute, Polish Academy of Science, Warsaw, Poland

    Janusz Kacprzyk

  3. Department of Automatics and Applied Software at the Faculty of Engineering, University “Aurel Vlaicu” Arad and Romanian Academy of Scientists, Arad, Romania

    Valentina Emilia Balas

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Ramli, S., Kadiri, M.S. (2024). Enhancing Tablet Manufacturing Efficiency Through Numerical Simulation and Modeling of Pharmaceutical Powder Compaction: A Comprehensive Review. In: Ezziyyani, M., Kacprzyk, J., Balas, V.E. (eds) International Conference on Advanced Intelligent Systems for Sustainable Development (AI2SD’2023). AI2SD 2023. Lecture Notes in Networks and Systems, vol 904. Springer, Cham. https://doi.org/10.1007/978-3-031-52388-5_26

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