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Advances in Mangiferin: Biosynthetic Pathways, Bioavailability and Bioactivity

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Handbook of Dietary Flavonoids

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Abstract

Mangiferin is a natural plant polyphenol of C-glycosylxanthone structure that has a potential effect for the treatment on various diseases thanks to its numerous biological activities. For a long time, the pharmaceutical industry has been interested in biologically active natural molecules due to their unique properties, bioavailability, and above all, significantly lower side effects compared to synthetic drugs. Numerous scientific research studies have shown that mangiferin has antioxidant, anti-infective, anticancer, antidiabetic, cardiovascular, neuroprotective, and immunomodulatory properties. However, mangiferin is not currently administered for clinical use because its oral bioavailability, as well as its absorption in the body, are considerably low in addition to considering all the ethical complications involved in carrying out such studies in humans. However, it is essential to note that the clinical trials carried out so far have encouraging results, which provides a good picture of the administration of mangiferin in humans. This chapter aims to explain the therapeutic potential of mangiferin, as well as its sources of production, possible mechanisms of action, biological effects, advances in its research in the medical field, as well as its toxicity.

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Acknowledgment

López-Cárdenas, F.G., acknowledgment to Consejo Nacional de Ciencia y Tecnología in Mexico for the Grant CVU 1009240 #003618, and all authors to the network ALSUB-CYTED, 118RT0543, from the Ciencia y Tecnología para el Desarrollo (CYTED).

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Authors and Affiliations

  1. Laboratorio Integral de Investigación en Alimentos, Instituto Tecnológico de Tepic, Tepic, Mexico

    Francia Guadalupe López-Cárdenas, Victor Manuel Zamora-Gasga, Jorge Alberto Sánchez-Burgos & Sonia G. Sáyago-Ayerdi

  2. Department of Metabolism and Nutrition (ICTAN–CSIC), Calle José Antonio Novais, Madrid, Spain

    Jara Pérez-Jiménez & Raquel Mateos-Briz

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  1. Francia Guadalupe López-Cárdenas
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  4. Victor Manuel Zamora-Gasga
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  5. Jorge Alberto Sánchez-Burgos
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  6. Sonia G. Sáyago-Ayerdi
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Correspondence to Sonia G. Sáyago-Ayerdi .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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López-Cárdenas, F.G., Pérez-Jiménez, J., Mateos-Briz, R., Zamora-Gasga, V.M., Sánchez-Burgos, J.A., Sáyago-Ayerdi, S.G. (2023). Advances in Mangiferin: Biosynthetic Pathways, Bioavailability and Bioactivity. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_53-1

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