Abstract
The more than 300 surgical techniques for hypospadias can be classified into eight basic principles. These principles include mobilization of the urethra; using the skin distal to the meatus; using the skin proximal to the meatus; using the preputial skin; using a combination of the prepuce and skin proximal to the meatus; using the scrotal skin; and using the dorsal penile skin or the use of different grafts. This chapter tries to give credit to the great pioneers who have helped to develop these principles and to show how these basic principles were gradually modified into the current state of the art.
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1 Short List of Men Behind Principles
The philosopher Santayana (1863–1952) said:
Those who cannot remember the past are condemned to repeat it.
In an address to the Royal College of Surgeons, Winston Churchill remarked [1]:
The longer you look back, the further you can look forward
As Durham Smith mentioned in his forward to the first edition of this book [2]:
Although the penile repairs can be grouped into five or six major principles, depending on the tissues used, each has been subject to countless variations as one surgeon after another adds yet another modification to an already thrice-modified variation of a procedure adapted from a principle derived from the original!
From Alexandria, Egypt came the first hypospadias pioneers, Heliodorus and Antyllus. Living in the first century, they were the first to describe and define the pathophysiology and treatment of hypospadias [3].
The aim of this chapter is to categorize the enormous variety of techniques in hypospadias into eight basic principles and to give credit to the great pioneers who first described these concepts (Table 2.1).
Thus, it is easier for the reader interested in hypospadias to grasp the basic concepts of hypospadias repair. The following account is by no means exhaustive, nor does it include all the techniques described for hypospadias repair.
In dealing with a boy with hypospadias, the surgeon has to correct the following major abnormalities:
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1.
Abnormal ventral curvature or chordee, by orthoplasty
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2.
Abnormal proximal meatal insertion, by urethroplasty
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3.
Abnormal-looking glans penis, by glanuloplasty and meatoplasty
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4.
Abnormal-looking prepuce, either by circumcision or prepuce reconstruction
2 Abnormal Ventral Curvature of the Penis (Chordee) and Orthoplasty
The history of chordee is mentioned in detail in the History Chapter (see Chap. 1), and the different approaches are mentioned in detail in the Chordee Chapter (see Chap. 8). Here, we will try to describe the principles behind the different approaches.
Gittes and McLaughlin, writing in 1974, described intraoperative saline inflation of the corpora cavernosa. This guided and ensured successful orthoplasty. This artificial erection test has been refined with saline and transglanular needle placement [33] (Fig. 2.1).
There are three types of chordee associated with hypospadias. The first is the chordee that is occasionally present in patients with distal hypospadias (skin chordee). This superficial chordee is subcutaneous, is proximal to the meatus, and is usually corrected by mobilization of the skin proximal to the meatus [60, 61] (Fig. 2.2).
The second type of chordee is commonly associated with proximal hypospadias or deep chordee. It is usually deep, fibrous, and located distal to the meatus. It is due to inadequate or arrested distal migration of the hypoplastic corpus spongiosum. There are three basic techniques to correct this type of deep, hypoplastic chordee (Fig. 2.3).
(a) The abnormal ventral curvature can be corrected by dorsal plication , first described by Physick [8] and popularized as the Nesbit procedure [62], but this has the serious disadvantage of shortening the penis. (b) More appropriately, the chordee can be corrected by excision of the ventral subcutaneous fibrous bands, usually proximal to the meatus in distal hypospadias (skin chordee). In proximal forms with severe chordee, curvature can be corrected by excision of the hypoplastic urethral plate and the longitudinal layer of tunica albuginea (tunica albuginea longitudinal excision or TALE ) (see Chap. 8). (c) A third method is by incising the corpora ventrally at the point of maximum curvature and putting grafts or flaps. Another way of correcting chordee is by corporal rotation, first described by Koff and Eakins [38]. Decter [57] added midline ventral splitting and called it the “split and roll” technique. Various skin and fascial grafts and flaps have been used to cover the resultant defect in multistage repair.
3 Abnormal Proximal Meatal Insertion and Urethroplasty
To correct hypospadias and achieve a terminal meatus, one may use one of the following basic principles or tissues: (1) distal mobilization of the urethra; (2) skin distal to the meatus; (3) skin proximal to the meatus; (4) preputial skin; (5) combined prepuce and skin proximal to the meatus; (6) scrotal skin; (7) dorsal penile skin; and (8) different grafts; a protective intermediate layer (Fig. 2.4).
3.1 Urethral Mobilization
Urethral mobilization and meatal advancement was first described by Beck [63] and Hacker in 1898 [64] (quoted in Horton 1973 [65]) for balanic hypospadias (Fig. 2.5).
The idea is to make use of the elasticity of the urethra. It is easier to understand the principle when one realizes that the adult flaccid penis is about 8 cm long. During erection, the penile length (including the urethra) reaches 15–20 cm long. This means that the normal urethra is flexible and can be stretched. The procedure has the advantage that it is theoretically “risk-free” as the urethra remains completely intact. It has the drawbacks that it can only be applied to very distal forms of hypospadias (grade I or glanular). If the stretched urethra is shorter than the stretched penis, one may risk bringing the glans to the urethra rather than the urethra to the tip of the glans, as the penis is not a rigid structure. Some surgeons reported good results with urethral mobilization [68,69,70,71]. This technique is still popular in some parts of Europe and America [72, 73].
Duckett [35] described the “meatal advancement and glanuloplasty incorporated” (MAGPI) procedure, which combines the use of the Heineke-Mikulicz technique with urethral mobilization in glanular hypospadias characterized by mobile urethra. Arap and his colleagues, in 1984 [66], modified the MAGPI procedure by placing two sutures on the ventral skin edge and forming an “M” configuration. Harrison and Grobbelaar [67] described the urethral advancement and glanuloplasty procedure (UGPI), which modifies MAGPI by having a V-shaped incision around the original meatus before mobilization and having deep glanular wings. The meatus is advanced to the tip of the glans, and two deep glanular wings are rotated upward and wrapped around the urethra. Hadidi in his double Y glanuloplasty (DYG) applied the Y-V principle to advance the mobile glanular meatus to the tip of the glans and avoid the globular-looking glans associated with MAGPI technique [51].
3.2 Use of Ventral Skin Distal to the Meatus
Reconstruction of a completely epithelialized neourethra may make use of the ventral skin distal to the meatus as in the Thiersch technique [10], pyramid repair as described by Duckett and Keating [43] for “megameatus intact prepuce” or MIP, the glans approximation procedure (GAP) by Zaontz [74], distal urethroplasty and glanuloplasty (DUG) by Stock and Hanna [75] (Fig. 2.6), and lateral-based onlay (LABO) by Hadidi [52], where he used the penile skin lateral to the urethral plate to reconstruct the new urethra to the tip of the glans.
Thiersch, 1869, used two parallel vertical incisions to wrap the ventral skin distal to the meatus around a catheter. He originally described this for repair of epispadias [10]. Then Theophile Anger (1874, 1875) [77] applied Thiersch’s concepts for epispadias to hypospadias. In the same edition of the Bulletin of the Surgical Society of Paris (1874) Duplay of Paris described the three-stage procedure for release of chordee and creation of the ventral tube, which was later joined to the functional meatus [78]. The same principle was adopted by Zaontz (1989) for patients with cleft glans and glanular hypospadias [74]. Also, Duckett and Keating used the same principle to correct the defect known as “megameatus intact prepuce” (MIP), present in about 6% of cases of distal hypospadias, and called it pyramid repair [43]. Stock and Hanna in 1997 [75] combined the Thiersch-Duplay principle with the longitudinal midline incision of MAGPI, closed transversely (Heineke-Mikulicz).
Another principle recommended the use of the ventral skin distal to the meatus to form an incompletely epithelialized neourethra. Techniques adopting this principle include those of Duplay [78], Browne [24], Reddy [79], Orkiszewski [80], Rich et al. [43], and Snodgrass [44].
Duplay was the first to state that it did not matter whether the central tube was incompletely formed [12]. He believed that epithelialization would occur to form a channel if the incomplete tube was buried under the lateral flaps. The same principle was adopted by Browne in his technique described in 1949 [24]. In both techniques, the defect was ventral. In 1989, Rich et al. described an incision of the urethral plate to obtain a cosmetically acceptable vertical slit meatus for Mathieu repair [43] . This dorsal midline incision was subsequently adopted for the entire length of the urethral plate as a complement to the Thiersch-Duplay urethroplasty for distal hypospadias by Snodgrass in 1994 [44]. The tubularized incised plate (TIP) urethroplasty differs in that the defect is dorsal and the suture line is protected by a preputial subcutaneous fascial flap (Fig. 2.7).
Historically, incision of the urethral plate was first described by Reddy [79], Orkiszewski who called it “the Deadman jacket” [80], and Rich et al. [43], before Snodgrass popularized the principle in 1994 [44].
4 Use of Ventral Skin Proximal to the Meatus (Meatal-Based Flaps)
A well-established group of techniques used the ventral skin proximal to the meatus as a meatal-based flap. This flap is used to form the ventral part of the neourethra as in the technique first described by Wood [11], Ombrédanne [18, 81], and Bevan [82] and popularized by Mathieu in 1932 [19]. Fevre [83], Mustardé [30], Barcat [84, 85], and Hadidi (Y-V [47] and SLAM [53]) described techniques using the same principle.
Wood [11] described a flap based distally on the meatus to be turned over to form the ventral surface of the neourethra.
Ombrédanne used a perimeatal flap but fashioned the neourethra using a purse-string suture [81]. The repair was too baggy. Mathieu used a perimeatal flap and constructed the neourethra using two lateral suture lines [19]. Mustardé used the same principle but differed in that he used the perimeatal flap to form the whole neourethra, not just the ventral surface [30]. This bore the advantage of having a single suture line deep to the urethra but has the disadvantage of losing the blood supply of the healthy urethral plate. Barcat modified the Mathieu technique by mobilizing the urethral plate and making a midline incision to push the neourethra deeper between the corpora [85]. The goal was always advancement of the neourethra to the glans tip. Stenosis and fistula were frequently the price. Fevre (1961) used a longer meatal-based flap and folded it between the glanular wings [83]. Mustardé included a V incision at the glans to achieve a wider meatus [30]. Hadidi included a Y incision at the tip of the glans closed as a V [47]. He further modified the technique in 2012 to achieve a terminal wide slit-like meatus in his technique slit-like adjusted Mathieu or SLAM technique [53] (Fig. 2.8).
4.1 Use of Preputial Skin
The preputial skin plays a very important role in the management of hypospadias (Fig. 2.9). It may be used in different ways:
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1.
The preputial skin may be mobilized ventrally to cover skin and fascial defects following excision of chordee in two-stage repair. Thiersch did the first buttonhole flap in the prepuce to allow resurfacing of the penis with the prepuce [10].
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2.
The preputial skin may be divided in the midline to form two flaps to cover the skin deficiency of the penis after chordee resection and after urethroplasty. This was described by Edmunds [17] and popularized by Byars [25].
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3.
The preputial skin may be used as a free skin graft to cover ventral defect after excision of ventral chordee as the first stage of two-stage repair. This was first described by Cloutier in 1962 [29] and popularized by Bracka [45, 46].
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4.
The preputial skin may be used as a free skin graft to form the neourethra in single-stage urethroplasty as first described by Devine and Horton in 1961 [27].
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5.
The preputial skin may be used as a pedicled flap for reconstruction of the neourethral tube. This may be vertical as described by Van Hook [13], Toksu [86], and Hodgson [87] or horizontal and double-faced as described by Asopa et al. [88]. Duckett [89] adopted this technique using the inner face of the prepuce in a horizontal manner now known as the tubularized preputial island flap technique (TPIF). Standoli described the same technique but used the outer face of the prepuce [90].
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6.
The preputial skin may be used as a pedicled flap to form the ventral wall of the neourethra (not the whole neourethra), as described by Elder et al. in the technique known as onlay island flap (OIF) in 1987 [41].
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7.
The preputial vascular fascia without skin may be used as a protective second layer to protect urethroplasty in the same way as after Mathieu and Snodgrass procedures, as first described by Retik et al. in 1988 [42].
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8.
The preputial skin may be used in continuation with a parameatal skin flap as in Koyanagi et al. [37], yoke repair (Snow) [91], and along with its fascia in the lateral-based flap technique (Hadidi) [50], bilateral-based flap (BILAB , Hadidi) [92], lateral-based onlay (LABO, Hadidi) [52], and chordee excision and distal urethroplasty (CEDU, Hadidi) [55].
4.2 Combined Use of Prepuce and Skin Proximal to the Meatus
In proximal hypospadias, one needs to reconstruct a long neourethra. Another principle employs the combined use of parameatal skin and the prepuce. This was first suggested by van Hook [13]. Many authors, including Broadbent et al. [28], DesPrez et al. [26], Hinderer [93], Koyanagi et al. [37], Snow [91], and Hadidi [50, 52, 54, 55], have described techniques using the same principle.
Van Hook [13] suggested the use of a “lateral oblique flap” from the side of the penis. Broadbent et al. [28], DesPrez et al. [26], and Hinderer [93] adopted the same principle and described a flap extending obliquely from the parameatal skin into the prepuce. Koyanagi et al. [37] modified the technique by using two lateral flaps (from both sides). Snow [91] described the yoke technique, which differed from Koyanagi in buttonholing the prepuce. Hadidi described the lateral-based flap technique using the same principle and combined it with Y-V glanuloplasty [47]. The technique entails adequate mobilization of the preputial vascular fascia with the flap. The lateral-based flap enjoys a double blood supply from the meatal base and the preputial vessels. The Y helps to bring the meatus to the tip, and the V excised from the tube helps to achieve a terminal slit-like meatus (Fig. 2.10).
4.3 Use of the Scrotum
The scrotum may be used in four different ways in hypospadias reconstruction (Fig. 2.11):
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1.
The scrotal skin may be used to form a completely epithelialized neourethra. Bouisson was apparently the first to report the use of scrotal tissue to reconstruct the ventral wall of the neourethra [9]. Rochet used a large scrotal flap for urethroplasty [94]. This flap was buried in a tunnel on the ventral surface of the penis. Lowsley and Begg constructed the neourethra completely from the scrotum [95]. This method fell into disuse because of the problem of hair growth into the neourethra.
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2.
The scrotal skin may be used to cover the neourethra. This was described by Beck in 1897 [96].
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3.
The scrotal skin may be used to reconstruct the neourethra and at the same time the scrotum is used to protect the neourethra until healing is complete. Rosenberger [97], Landerer [98], and Bidder [99], used scrotal skin for urethroplasty. They described for the first time burying of the penis in the scrotum to obtain skin coverage. This was modified by Bucknall [100].
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4.
The scrotum may be used as a bed for the neourethra, a technique that was popularized by Cecil [22] and Culp in 1966 [101] (Cecil-Culp technique).
4.4 Use of Dorsal Penile Skin
Davis, in 1940, tubed the dorsal penile skin with the base proximal in the direction of the circulation [20] (Fig. 2.12). The detached distal end of this tube was passed through a channel in the glans and penis by angulating the penis acutely upward and backward. In the second stage, the proximal pedicle was cut and the penis returned to its normal position. The penile gymnastics required for the Davis procedure apparently seemed too demanding for most surgeons. Hodgson [87] and Perovic [102] used longitudinal dorsal skin flaps to reconstruct the new urethra.
4.5 Use of Grafts
Nové-Josserand in 1897 started another school of urethroplasty which utilized the free inlay graft [16]. He used a thin split-thickness free graft from the inner thigh and applied the raw surface outward around a metal probe. Sir Archibald McIndoe used a partial-thickness skin graft from the inner upper arm [103]. Young and Benjamin also used a split-thickness skin graft from the medial aspect of the upper arm [104]. From 1909 to 1927, a whole series of homograft including vein, urethra, and appendix were attempted but never with any consistent success. Cloutier used the full thickness prepuce as the graft material after excising the chordee using a T-shaped incision into the glans [29]. He then stitched the graft to the edges of the resulting defect (including the glans). In addition, he quilted the graft to the center to ensure better take of the graft. Nicolle [105] and Bracka [45] popularized the use of full-thickness skin graft from the prepuce. Memmelaar, in 1947, was the first to advocate the use of bladder mucosa [23]. Although Humby [21] first proposed and reported the use of buccal mucosa for hypospadias repair, Duckett in 1986 [106] promoted the technique and is credited for the current enthusiasm and widespread acceptance of its use in complex hypospadias repairs (Fig. 2.13). Fine et al. described tunneling of buccal mucosal tube graft for proximal hypospadias [107].
5 Use of a Protective Intermediate Layer
An important principle in hypospadias repair is to avoid having the skin suture line on top of the urethroplasty suture line. Thiersch as early as 1868 designed his asymmetric U-shaped incision to avoid having the two suture lines on top of each other [10]. Smith was the first to describe the use of an intermediate or interposition layer between the neourethra and the cutaneous suture [32]. Types of interposition waterproofing layer include Smith’s de-epithelialized skin [32], Snow’s tunica vaginalis wrap from the testicular coverings [39], Retik et al.’s dorsal subcutaneous flap from the foreskin [42], Motiwala’s dartos flap from the scrotum [108], and Yamataka et al.’s external spermatic fascia flap [109] (Fig. 2.14).
6 Abnormal-Looking Glans Penis and Glanuloplasty and Meatoplasty
Thus, various tubes and patches were available to reconstruct the neourethra. The next step was to bring the neourethra to the tip of the glans. The glans had always posed a challenge and had largely not been found amenable to tunneling. Canalization, tunneling, and coring are essentially the same, with progressively larger channels. These are a testimony to glans stenosis.
There are several techniques employed to achieve an apical meatus (Fig. 2.15):
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(a)
Russell (1900) described the glans channel technique to deliver the urethra to the apex of the glans [110]. Bevan (1917) [82], Davis (1940) [20], Ricketson (1958) [111], Duckett (1980b) [112], and Hendren (1981) [113] used the same principle but different flaps or grafts.
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(b)
Wing rotation is used in most recent techniques.
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(c)
Devine and Horton [27] and Mustardé [30] popularized the glans channel procedure and included a dorsal V-flap with the glans channel.
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(d)
The glans split has been used in various techniques to move the meatus to the apex [15, 21, 85, 114,115,116].
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(e)
Duckett, in 1981, described the “meatal advancement and glanuloplasty incorporated” (MAGPI) procedure [35]. Arap et al. modified the MAGPI technique by using two sutures instead of one [66]. Decter, in 1991, described an “M inverted V” technique [117].
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(f)
Rich et al. described incising the urethral plate in the midline (hinging) [43]. This helped to achieve a slit-like vertical meatus.
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(g)
Snodgrass extended the concept of urethral plate hinging by incising the whole urethral plate in the midline from the hypospadiac meatus distally [44]. This helps in tubularization of the plate.
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(h)
Hadidi, in 1996, described the Y-V glanuloplasty [47]. The center of the Y is at the tip of the glans. Each limb is 0.5 cm long and the deep incision is closed as a V. The dog-ears created are widely opened to increase the circumference. A V is excised from the distal end of the neourethra to achieve a slit-like meatus. The Y-V glanuloplasty can be combined with most techniques of hypospadias repair, e.g., Mathieu, Onlay, Duplay, transverse preputial island flap urethroplasty, and lateral-based flap.
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(i)
Boddy and Samuel described the “Mathieu and V incision sutured” (MAVIS) technique, which results in a vertical slit meatus [58]. In this technique a V incision is made and excised at the apex of the parameatal-based flap. Then each side of the V is sutured to the glanular wings.
Abbreviations
- BILAB:
-
Bilateral-based flap
- CEDU:
-
Chordee excision and distal urethroplasty
- DUG:
-
Distal urethro-glanuloplasty
- DYG:
-
Double Y glanulomeatoplasty
- LABO:
-
Lateral-based onlay flap
- MAGPI:
-
Meatal advancement and glanuloplasty incorporated
- MAVIS:
-
Mathieu and V incision sutured
- MIP:
-
Megameatus intact prepuce
- OIF:
-
Onlay island flap
- SLAM:
-
Slit-like adjusted Mathieu
- TALE:
-
Tunica albuginea longitudinal excision
- TIP:
-
Tubularized incised plate
- TPIF:
-
Tubularized preputial island flap
- UGPI:
-
Urethral advancement and glanuloplasty procedure
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Hadidi, A.T. (2022). Men Behind Principles and Principles Behind Techniques. In: Hadidi, A.T. (eds) Hypospadias Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-94248-9_2
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