Abstract
Neuroimaging plays a central role in the initial diagnosis, follow-up, prognosis, and decision-making for various acute intracranial pathologies in children. Whereas the rarity of several of these conditions in children, poorly understood natural histories, limited representation in the literature, nonspecificity of clinical signs, and heterogeneity of treatment responses make frequent neuroimaging desirable, this has to be counterbalanced against associated risks and costs. Considerations which are usually relatively straightforward and minor in adult patients can lead to substantial morbidity and anxiety in pediatric hospitals, for instance, extravasation of even a small amount of IV contrast agent can result in limb edema and/or compartment syndrome. Imaging examinations in small children often require general anesthesia. Similarly, procedures that entail ionizing radiation, i.e., CT and digital subtraction angiography, necessitate diligent justification with dialogue between the neuroradiologist and the clinical team, with every effort made to ensure that call-back examinations are eliminated. This also implies that alternative imaging be performed when feasible for obtaining similar information, for instance, awake bedside transcranial Doppler or alternative fast sequence MR protocol under adequate clinical indications, to assess ventricular size in infants. In yet other cases, established adult pipelines for neuroimaging are not necessarily suitable in children, such as multiphasic CTA for adult stroke patients for triaging of endovascular therapy. Lastly, the availability of pediatric-trained nurses and technologists in a radiology department is fundamental to minimizing morbidity and obtaining high-quality images and for the care of pediatric patients undergoing interventional procedures.
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References
Exo J, Smith C, Smith R, Bell M. Emergency treatment options for pediatric traumatic brain injury. Pediatr Health. 2009;3(6):533–41.
Case ME, Graham MA, Handy TC, Jentzen JM, Monteleone JA. National Association of medical examiners ad hoc committee on Shaken Baby syndrome. Position paper on fatal abusive head injuries in infants and young children. Am J Forensic Med Pathol. 2001;22(2):112–22.
Kumpulainen V, Lehtola SJ, Tuulari JJ, Silver E, Copeland A, Korja R, et al. Prevalence and risk factors of incidental findings in brain MRIs of healthy neonates – the FinnBrain birth cohort study. Front Neurol. 2020;10:1347.
Poussaint TY, Moeller KK. Imaging of pediatric head trauma. Neuroimaging Clin N Am. 2002;12(2):271–94.
Rooks VJ, Eaton JP, Ruess L, Petermann GW, Keck-Wherley J, Pedersen RC. Prevalence and evolution of intracranial hemorrhage in asymptomatic term infants. Am J Neuroradiol. 2008;29(6):1082–9.
Looney CB, Smith JK, Merck LH, Wolfe HM, Chescheir NC, Hamer RM, et al. Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors. Radiology. 2007;242(2):535–41.
Chaturvedi A, Chaturvedi A, Stanescu AL, Blickman JG, Meyers SP. Mechanical birth-related trauma to the neonate: an imaging perspective. Insights Imaging. 2018;9(1):103–18.
Popernack ML, Gray N, Reuter-Rice K. Moderate-to-severe traumatic brain injury in children: complications and rehabilitation strategies. J Pediatr Health Care. 2015;29(3):e1–7.
Wang H, Zhou Y, Liu J, Ou L, Han J, Xiang L. Traumatic skull fractures in children and adolescents: a retrospective observational study. Injury. 2018;49(2):219–25.
Armin SS, Colohan ART, Zhang JH. Vasospasm in traumatic brain injury. Acta Neurochir Suppl. 2008;104(13):421–5.
Paul AR, Adamo MA. Non-accidental trauma in pediatric patients: a review of epidemiology, pathophysiology, diagnosis and treatment. Transl Pediatr. 2014;3(3):195–207.
Vezina G. Assessment of the nature and age of subdural collections in nonaccidental head injury with CT and MRI. Pediatr Radiol. 2009;39(6):586–90.
Gunda D, Cornwell BO, Dahmoush HM, Jazbeh S, Alleman AM. Pediatric central nervous system imaging of nonaccidental trauma: beyond subdural hematomas. Radiographics. 2018;39(1):213–28.
Orman G, Kralik SF, Meoded A, Desai N, Risen S, Huisman TAGM. MRI findings in pediatric abusive head trauma: a review. J Neuroimaging. 2020;30(1):15–27.
Silvera VM, Danehy AR, Newton AW, Stamoulis C, Carducci C, Grant PE, et al. Retroclival collections associated with abusive head trauma in children. Pediatr Radiol. 2014;44(4):621–31.
Wright JN. CNS injuries in abusive head trauma. AJR Am J Roentgenol. 2017;208(5):991–1001.
Khan NR, Fraser BD, Nguyen V, Moore K, Boop S, Vaughn BN, et al. Pediatric abusive head trauma and stroke. J Neurosurg Pediatr. 2017;20(2):183–90.
Lo WD, Lee J, Rusin J, Perkins E, Roach ES. Intracranial hemorrhage in children: an evolving Spectrum. Arch Neurol. 2008;65(12):1629–33.
Cole L, Dewey D, Letourneau N, Kaplan BJ, Chaput K, Gallagher C, et al. Clinical characteristics, risk factors, and outcomes associated with neonatal hemorrhagic stroke: a population-based case-control study. JAMA Pediatr. 2017;171(3):230–8.
El-Ghanem M, Kass-Hout T, Kass-Hout O, Alderazi YJ, Amuluru K, Al-Mufti F, et al. Arteriovenous malformations in the pediatric population: review of the existing literature. Intervent Neurol. 2016;5(3–4):218–25.
Walcott BP, Smith ER, Scott RM, Orbach DB. Pial arteriovenous fistulae in pediatric patients: associated syndromes and treatment outcome. J NeuroIntervent Surg. 2013;5(1):10–4.
Jhaveri A, Amirabadi A, Dirks P, Kulkarni AV, Shroff MM, Shkumat N, et al. Predictive value of MRI in diagnosing brain AVM recurrence after angiographically documented exclusion in children. AJNR Am J Neuroradiol. 2019;40(7):1227–35.
Päivi K-P, Mika N, Hanna L, Riku K, Jussi N, Aki L, et al. De novo and recurrent aneurysms in pediatric patients with cerebral aneurysms. Stroke. 2013;44(5):1436–9.
Bisson D-A, Dirks P, Amirabadi A, Shroff MM, Krings T, Pereira VM, et al. Unruptured intracranial aneurysms in children: 18 years’ experience in a tertiary care pediatric institution. J Neurosurg Pediatr. 2019;24(2):184–9.
Dmytriw AA, Bisson D-A, Phan K, Amirabadi A, Branson H, Dirks PB, et al. Locations, associations and temporal evolution of intracranial arterial infundibular dilatations in children. J Neurointervent Surg. 2020;12(5):495–8.
Krings T, Geibprasert S, terBrugge KG. Pathomechanisms and treatment of pediatric aneurysms. Childs Nerv Syst. 2010;26(10):1309–18.
Tsze DS, Valente JH. Pediatric stroke: a review. Emerg Med Int. 2011; [cited 2020 Apr 25]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255104/
Mirsky DM, Beslow LA, Amlie-Lefond C, Krishnan P, Laughlin S, Lee S, et al. Pathways for neuroimaging of childhood stroke. Pediatr Neurol. 2017;69:11–23.
Bhatia K, Kortman H, Blair C, Parker G, Brunacci D, Ang T, et al. Mechanical thrombectomy in pediatric stroke: systematic review, individual patient data meta-analysis, and case series. J Neurosurg Pediatr. 2019:1–14.
Grunt S, Wingeier K, Wehrli E, Boltshauser E, Capone A, Fluss J, et al. Cerebral sinus venous thrombosis in Swiss children. Dev Med Child Neurol. 2010;52(12):1145–50.
Rollins N, Ison C, Reyes T, Chia J. Cerebral MR venography in children: comparison of 2D time-of-flight and gadolinium-enhanced 3D gradient-Echo techniques. Radiology. 2005;235(3):1011–7.
Triulzi F, Doneda C, Parazzini C. Neuroimaging of pediatric brain infections. Expert Rev Anti-Infect Ther. 2011;9(6):737–51.
Okanishi T, Yamamoto H, Hosokawa T, Ando N, Nagayama Y, Hashimoto Y, et al. Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. Brain and Development. 2015;37(4):423–31.
Jayaraman K, Rangasami R, Chandrasekharan A. Magnetic resonance imaging findings in viral encephalitis: a pictorial essay. J Neurosci Rural Pract. 2018;9(4):556–60.
Park JY, Ko KO, Lim JW, Cheon EJ, Yoon JM, Kim HJ. A pediatric case of Bickerstaff’s brainstem encephalitis. Korean J Pediatr. 2014;57(12):542–5.
Oliveira CR, Morriss MC, Mistrot JG, Cantey JB, Doern CD, Sánchez PJ. Brain magnetic resonance imaging of infants with bacterial meningitis. J Pediatr. 2014;165(1):134–9.
Pienaar M, Andronikou S, van Toorn R. MRI to demonstrate diagnostic features and complications of TBM not seen with CT. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg. 2009;25(8):941–7.
Grant PE, Yu D. Acute injury to the immature brain with hypoxia with or without hypoperfusion. Radiol Clin N Am. 2006;44(1):63–77, viii
Huang BY, Castillo M. Hypoxic-ischemic brain injury: imaging findings from birth to adulthood. Radiographics. 2008;28(2):417–39.
Tardieu M, Banwell B, Wolinsky JS, Pohl D, Krupp LB. Consensus definitions for pediatric MS and other demyelinating disorders in childhood: table. Neurology. 2016;87(9 Suppl 2):S8–11.
Banwell B, Arnold DL, Tillema J-M, Rocca MA, Filippi M, Weinstock-Guttman B, et al. MRI in the evaluation of pediatric multiple sclerosis. Neurology. 2016;87(9 Suppl 2):S88–96.
Gibbs WN, Kreidie MA, Kim RC, Hasso AN. Acute hemorrhagic leukoencephalitis: neuroimaging features and neuropathologic diagnosis. J Comput Assist Tomogr. 2005;29(5):689–93.
Reis E, Coolen T, Lolli V. MRI findings in acute hyperammonemic encephalopathy: three cases of different etiologies. J Belg Soc Radiol. 2020;104(1):9.
Abbott R, Silber E, Felber J, Ekpo E. Osmotic demyelination syndrome. BMJ. 2005;331(7520):829–30.
Pillai A, Rajeev K, Unnikrishnan M. Surgical management of a pial arteriovenous fistula with giant varix in an infant. Neurol India. 2006;54(4):434–6.
Madsen PJ, Lang S-S, Pisapia JM, Storm PB, Hurst RW, Heuer GG. An institutional series and literature review of pial arteriovenous fistulas in the pediatric population: clinical article. J Neurosurg Pediatr. 2013;12(4):344–50.
Morales H, Jones BV, Leach JL, Abruzzo TA. Documented development of a dural arteriovenous fistula in an infant subsequent to sinus thrombosis: case report and review of the literature. Neuroradiology. 2010;52(3):225–9.
Hoang S, Choudhri O, Edwards M, Guzman R. Vein of Galen malformation. Neurosurg Focus. 2009;27(5):E8.
Bhatia K, Mendes Pereira V, Krings T, Ter Brugge K, Kortman H, Dirks P et al. Factors contributing to major neurological complications from vein of Galen malformation embolization. JAMA Neurol. 2020.
Lasjaunias P. Vein of Galen aneurysmal malformation. In: Lasjaunias P, editor. Vascular diseases in neonates, infants and children: interventional neuroradiology management [Internet]. Berlin/Heidelberg: Springer; 1997. p. 67–202. https://doi.org/10.1007/978-3-662-10740-9_2. [cited 2020 May 27].
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Muthusami, P., Dmytriw, A.A., Shroff, M.M. (2022). Imaging of Pediatric Traumatic and Nontraumatic Brain Emergencies. In: Patlas, M.N., Katz, D.S., Scaglione, M. (eds) Atlas of Emergency Imaging from Head-to-Toe. Springer, Cham. https://doi.org/10.1007/978-3-030-92111-8_44
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