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Antimicrobial Marine-Derived Materials

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Handbook of the Extracellular Matrix

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Abstract

Currently, the next generation of natural-based antimicrobial systems has been developed, showing the potential to prevent and eliminate microorganisms in various environments. Within this context, the antibacterial activity of marine-derived polymers supports the creation of antimicrobial-based formulations as alternative strategy for antibiotic use. Marine renewable sources such as crab shells, squid pens, and mollusks are the sustainable feedstock of high-value polymers, extracts, and bioactive compounds. In addition, marine-derived polymers show low cost, high availability, biodegradability, and biocompatibility. Furthermore, they can be easily designed as 2D/3D-based structures, namely, membranes, hydrogels, microfibers, and scaffolds, opening a wide range of possibilities for biomedicine use. This chapter discusses the latest developments in antimicrobial systems based on marine-derived structures, focusing on alginate, carrageenan, chitin/chitosan, collagen, chondroitin sulfate, fucoidan, gelatin, hyaluronic acid, and ulvan. Moreover, their mechanism of action and their biomedical applications are also examined, where more close international collaboration is needed to address those issues.

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Abbreviations

3D:

Three-dimensional

Ag:

Silver

AgNPs:

Silver nanoparticles

AMPs:

Antimicrobial peptides

AMR:

Antimicrobial resistance

BBR:

Berberine

BBR-F:

Chelidonium majus L

BL:

Blue light

BMSCs:

Bone marrow stem cells

CEC:

N-Carboxyethyl chitosan

Cht:

Chitosan

Cht-FA:

Chitosan-fatty acid

Cht-NPs:

Chitosan nanoparticles

CNF:

Chitin nanofibrils

ColChHAmod:

Collagen/chitosan/lysine-modified hyaluronic acid based hydrogels

-COOH:

Carboxylic group

CS:

Chondroitin sulfate

CTP-SA:

Sodium alginate hydrogel composite

Cu2O:

Cubic cuprous oxide

CUR:

Curcumin

DD:

Degree of deacetylation

E. coli :

Escherichia coli

ECM:

Extracellular matrix

FC:

Fish collagen

FDA:

US Food and Drug Administration

FGF:

Fibroblast growth factors

FGFs:

β-Fibroblast growth factors

G−:

Gram-negative bacteria

G+:

Gram-positive bacteria

GO:

Graphene oxide

GO-NPs:

Graphene oxide nanoparticles

HA:

Hyaluronic acid

HANr:

Hydroxyapatite nanorods

IL:

Ionic liquid

IO-NPs:

Iron oxide nanoparticles

MC:

Mammalian collagen

MC:

Marine collagen

MMC:

Mammalian collagen

MP:

Marine peptide

MW:

Molecular weight

NO:

Nitric oxide

NPs:

Nanoparticles

OCD:

Osteocondral defects

OH:

Hydroxyl group

OHA-AT:

Oxidized hyaluronic acid-graft-aniline tetramer

P. aeruginosa :

Pseudomonas aeruginosa

PLA:

Polylactic acid

PU:

Polyurethane

ROS:

Reactive oxygen species

S. aureus :

Staphylococcus aureus

SNAP:

S-Nitroso-N-acetylpenicillamine

SSD:

Silver sulfadiazine

TEOS:

Tetraethyl orthosilicate

TERM:

Tissue engineering and regenerative medicine

TGF-β1:

Transforming growth factor

TiO2@PDA:

Polydopamine-coated titanium dioxide

VEGF:

Vascular endothelial growth factor

ZnO:

Zinc oxide

ι:

Iota

κ:

Kappa

λ:

Lambda

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Acknowledgments

The authors especially acknowledge financial support from Portuguese FCT (SFRH/BPD/93697/2013 and CEECIND/01306/2018), and through Northern Portugal Operation Program (NORTE2020), under the scope of the project TERM RES Hub-Infraestrutura Científica para a Engenharia de Tecidos e Medicina Regenerativa, Refª Norte-01-0145-FEDER-02219015.

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Authors and Affiliations

  1. 3B’s Research Group- Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Simone S. Silva, Emanuel M. Fernandes, Luísa C. Rodrigues & Rui L. Reis

  2. ICVS/3B’s – PT Government Associate Laboratory, Guimarães, Braga, Portugal

    Simone S. Silva, Emanuel M. Fernandes, Luísa C. Rodrigues & Rui L. Reis

Authors
  1. Simone S. Silva
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  2. Emanuel M. Fernandes
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  3. Luísa C. Rodrigues
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  4. Rui L. Reis
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Corresponding author

Correspondence to Simone S. Silva .

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Editors and Affiliations

  1. 3B’s Research Group, University of Minho, Barco, Portugal

    Fatima Raquel Azevedo Maia

  2. 3B's Research Group, University of Minho, Guimarães, Portugal

    J. Miguel Oliveira

  3. Dept Polymer Engg, 3Bs Research Grp, University of Minho, Guimaraes, Portugal

    Rui L. Reis

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Silva, S.S., Fernandes, E.M., Rodrigues, L.C., Reis, R.L. (2023). Antimicrobial Marine-Derived Materials. In: Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix. Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_56-1

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  • DOI: https://doi.org/10.1007/978-3-030-92090-6_56-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-92090-6

  • Online ISBN: 978-3-030-92090-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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