Keywords

The word “myopia” is thought to be derived from New Latin, original Greek word “mῠopia” (μυωπία, from myein “to shut” + ops [gen. opos] “eye”), which means contracting or closing the eye. This is a description of the typical facial expression of the uncorrected myopia when a patient attempts to obtain clear distance vision. Before the introduction of spectacles, squinting the eyelids resulting in a horizontal stenopeic slit was the only practical way to achieve clearer distance vision. In ancient times, the myope was reliant upon others with normal vision for the spoils of the hunt and protection in war. In prehistoric times, this dependency must have been even greater. With the advent of civilization, the emergence of agricultural handicrafts, and the written word, the nearsighted at least found a place of more worth in society. As knowledge and fine skills have become increasingly important in our advancing culture, this place of the myopia has been continually expanded.

For tracing the historical perspectives of pathologic myopia in the ophthalmic literature, the first to consider is the evolution of our knowledge of myopia, which has been marked by occasional giant strides based on numerous careful investigations. However, conflicting observations on this subject have been bewildering by their varied and complex protocols and their results and conclusions. A tendency toward advocacy rather than investigatory curiosity can be seen to influence the early literature. Yet, myopia remains one of the major causes of visual disability and blindness to this day. As a result, myopia continues to be one of the major perplexing problems worldwide. Table 1.1 lists some historical landmarks in myopia.

Table 1.1 Historical landmarks in myopia
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1 Pre-ophthalmoscopic Historical Landmarks in Myopia

Pre-ophthalmoscopic development in myopia started from light, optics, and anatomical studies. There are many reviews of the history of myopia [1,2,3,4,5,6]. Aristotle (384–321 BC) was generally thought to be the first to consider the problem seriously (Fig. 1.1). He described the difference between “long sight” and “short sight” and noted the tendency of the myopia to blink the lids and write in small script [7]. Galen’s (138–201 AD, Fig. 1.2) concepts dominated the early years of medicine. Galen thought that ocular refraction was dependent upon both the composition and quantity of the eye fluids (animal spirit), and he was the first to use the term myopia [7]. From Aristotle’s time, it was believed that the eye itself was a source of vision rays, an idea finally dismissed by Alhazin (AD 1100) [8]. Optical correction and myopia evolved very slowly. Although Nero is believed to have watched gladiator battles through a concave ruby, correcting spectacles did not make their appearance until near the end of the thirteenth century, and the myopia had to wait a few more centuries before the introduction of minus lenses.

Fig. 1.1
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Painting of Aristotle by Francesco Hayez (1791–1882)

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Fig. 1.2
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A portrait of Galen by Pierre Roche Vigneron. (Paris: Lith de Gregoire et Deneux, ca. 1865). (Courtesy of the National Library of Medicine)

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The optics and image formation of refraction were poorly understood in those times. Porta (1558–1593) believed that the image fell on the anterior surface of the lens, whereas his contemporary, Maurolycus (1575), thought that the lens was involved in focusing the image and that it was more convex in myopia and flatter in hyperopia [9]. He did not mention the retina and believed the focal plane was on the optic nerve. Adding to the confusion was the problem of obtaining an upright image in the eye, an accomplishment that early workers considered indispensable for normal vision. A dramatic step forward was made by Kepler (Fig. 1.3), who seemed appropriate to address the subject because of his background in mathematics. In 1604, Kepler demonstrated the image formation of the eye and the role played by the cornea and lens. He placed the inverted image at the retina and defined the action of convex and concave lenses upon this system [10]. Later, Kepler noted that parallel rays of light fell in front of the retina in myopic eyes [11]. Kepler further attributed the ability to see clearly at both distance and near to alterations in the shape of the eye. He went on to propose the “near-work” hypothesis for myopia by stating that study and fine work in childhood rapidly accustoms the eye to near objects [11]. With aging, this adaptive mechanism produces a permanent, finite far point such that distant objects were seen poorly, a theory that is still accepted today [9].

Fig. 1.3
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A 1610 portrait of Johannes Kepler by an unknown artist

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Newton (1704) wrote about the concept of hyperopia as a condition due to parallel rays of light converging behind the retina and set the stage for the acceptance of axial length of the eye as the sole determinant of refraction. Plempius (1632) [9] provided anatomical proof of increased axial lengthening of the eye, and Boerhaave (1708) confirmed this lengthening and also reported the other cause of myopia: increased convexity of the refractive surfaces [12].

In the absence of the instruments necessary to measure corneal and lenticular variables, there were some studies confirming the variability of axial length. These included the studies of Morgagani (1761) [9], Guerin (1769) [9], Gendron (1770) [5], and Pichter (1790) [5]. Scarpa (Fig. 1.4 upper) is the first to describe anatomically posterior staphyloma (Fig. 1.4 lower) in two female eyes in 1801 [13]. He coined the Greek word “staphylos” which literally means “a bunch of grapes.” It is of note that Scarpa described staphyloma but did not link it to myopia. Von Ammon (1832) noted that posterior staphyloma was due to a distention of the posterior pole and was not a rare entity. However, he did not make a link either from posterior staphyloma to myopia [14].

Fig. 1.4
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Upper: Portrait of Antonio Scarpa; Lower: The earliest depiction of posterior staphyloma as contained in the text of Antonio Scarpa [13]

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2 Post-ophthalmoscopic Historical Landmarks in Myopia (1851)

Post-ophthalmoscopic development in myopia started from observations of the optic nerve, macula, and chorioretinal changes. Von Graefe (1854) first postulated the association between myopia and axial length in a combined ophthalmoscopic and anatomical study of two eyes measuring 29 mm and 30.5 mm in length [15]. However, it was Arlt’s (1856) (Fig. 1.5) anatomical studies that convinced the scientific world of the intimate association of myopia with axial elongation of the globe at the expense of the posterior pole [16]. After Arlt made the connection between staphyloma and myopic refraction [16], clinical findings in pathologic myopia were investigated.

Fig. 1.5
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A portrait of Carl Ferdinand Ritter von Arlt by Fritz Luckhardt. The anatomical studies of Carl Ferdinand Ritter von Arlt convinced the scientific world of the intimate association of myopia with axial elongation of the globe at the expense of the posterior pole

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Von Jaeger (Fig. 1.6) was the first to describe and illustrate myopic conus and enlarged subarachnoid space around the nerve in 1861 [17]. He found that the choriocapillaris was sometimes absent within the limits of the conus and that in extensive staphyloma the choroid over the conus presented the appearance of a glass-like membrane which was exceedingly fine and delicately striated and contained a few vessels [17]. In 1862, Carl Friedrich Richard Förster (Fig. 1.7, upper) first observed sub-RPE choroidal neovascularization (CNV) (Fig. 1.7, lower) [18], and this is what we called “Forster spots.” In 1901, Ernst Fuchs (Fig. 1.8, left) later discovered “central black spot in myopia” [19] (Fig. 1.8, right) [20], and this is what we called “Fuchs’ spots.” Fuchs concluded that the choroid is not destroyed, but is either converted into, or covered by, a callosity. It starts with sudden visual disturbances in the form of metamorphoses or positive scotomas, which in the course of years become more marked. Anatomically, there is an intense proliferation of the pigment epithelium covered by a gelatinous acellular exudation (coagulum of fibrin), adherent to the retina, but the etiology was obscure [12]. Henry Wilson described atrophy of choroidal epithelium in 1868 [21]. In 1902, Salzmann (Fig. 1.9, left) noted that cleft-shaped or branched defects were found in atrophic areas in the lamina vitrea that were concentric with the optic disc (Fig. 1.9, Right) [22, 23]. The lamina vitrea is also referred to as “Bruch’s membrane.” He felt that these defects seemed to be the result of purely mechanical stretching. Later, the term “lacquer cracks” was used by Curtin and Kerlin to describe this lesion, which typically occurs as yellowish to white lines in the posterior segment of highly myopic eyes, resulting from progressive eyeball elongation. Salzmann believed that atrophic changes noted in the myopic choroid followed inflammation and the primary process driving this was stretching of the choroidal stroma [24].

Fig. 1.6
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A portrait of Eduard Jäger von Jaxtthal by Adolf Dauthage in 1859

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Fig. 1.7
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Upper: A portrait of Carl Friedrich Richard Förster. (Reprinted with permission from The Royal Library, The National Library of Denmark and Copenhagen University Library); Lower: Cross-section of the retina, choroid, and sclera from a myopic eye shows a circumscript inclusion in the choroidal stroma which encroaches into the anterior layer of the choroid. (Förster [18])

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Fig. 1.8
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Left: Portrait of Ernst Fuchs. Original etching by Emil Orlik, 1910. (Reprinted with permission from the Medical University of Vienna, Austria); Right: The earliest figure of “Fuchs’ spot,” which was described by Dr. Ernst Fuchs as “The central black spot in myopia.” (Fuchs [20])

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Fig. 1.9
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Left: Photograph of Maximilian Salzmann, M.D. (Reprinted with permission from The Royal Library, The National Library of Denmark and Copenhagen University Library); Right: Top: Break in lamina of Bruch covered with the epithelium. Middle: Changes in the epithelium. Bottom: Break in lamina with epithelial covering and hyaline membrane. (Salzmann [23])

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3 Modern Historical Landmarks in Myopia

Modern historical landmarks include studies dedicated to exploring the individual optical elements of myopia, axial length measurement (X-ray and ultrasound), and the development of contact lenses.

The greatest efforts of the ophthalmologic community were concentrated on a search for the causes of increased axial length of the eye. Donders [1] appreciated that axial length was not the sole determinant of refraction. Schanbe and Harrneiser (1895) had found axial lengths varying from 22.25 to 26.24 mm in 35 emmetropic eyes and hypothesized that emmetropia could be determined by axial length and total refraction [25]. Ludwig Hein (1899) thought that myopia was due to elongation of the globe [8]. Steiger (1913), in a large statistical study of corneal power in children, deemphasized the importance of axial length as the only determinant of refraction. His biomathematical study was large (5000 children), but his experimental method was somewhat faulty in that he assumed lens power to be a constant and therefore calculated the axial length of the eye from total refraction in this manner [9]. The variability of lens power had been alluded to as early as 1575 by Maurolycus [5], and variations in lens thickness, refractive index, and position had been considered as possible causes of myopia prior to Donder’s time [1]. In addition, actual lens power measurements, albeit in small samples, had been demonstrated by von Reuss (1887–1890), Awerbach (1900), and Zeeman (1911) to show considerable variations [7]. Steiger’s corneal measurements gave a Gaussian curve extending from 39 D to 48 D [26]. He did not note any set value of corneal power in emmetropia. He further made a distribution curve of +7 D to −7D using his corneal values and calculated axial lengths found in emmetropia (21.5–25.5 mm). Steiger viewed emmetropia and refractive errors as points on a normal distribution curve, with corneal power and axial lengths as free and independent variables [26]. Tscherning (1854–1939) was crucial in the understanding of optics in pathologic myopia [27], and he made many contributions in this area. In addition, he wrote a thesis about the frequency of myopia in Denmark [28]. Schnabel, Fuchs, Siegrest, and Elschnig were important to the studies of histopathology in myopic eyes, especially in relation to optic nerve changes in pathologic myopia [9]. These concepts brought an entirely new approach to the study of myopia.

Tron (1934–1935) followed with a study of 275 eyes and carefully avoided the pitfalls of Steiger’s work [29, 30]. In his study, the only optical element not measured directly was axial length, which was calculated from the refraction, corneal power, lens power, and anterior chamber depth. Tron confirmed the wide range of axial lengths in emmetropia (22.4–27.3 mm) [29]. He also deduced that axial length was the determining factor for refraction only in the range beyond +4 D and −6 D [29]. He obtained essentially binomial curves for all the elements of refraction except for axial length. With the elimination of myopic eyes of more than 6 D, the curve for axial length also assumed a normal distribution [7]. Stenstrom (1946) [31] directly measured axial length by using X-rays contributed by the development of this technique by Rushton (1938) [32]. Stenstrom studied 1000 right eyes and confirmed the results Tron had obtained in his smaller series. Both biometric studies found essentially normal distribution curves for corneal power, anterior chamber depth, lens power, and total refraction. Both also showed a peaking (excess) for axial length above the binomial curve as well as an extension of the limb toward increased axial length (skewness) [29, 31]. Stenstrom noted that the distribution curve of refraction had basically the same disposition as that of axial length, featuring both a positive excess at emmetropia and a skewness toward myopia [5].

This deviation in the population refraction curve had been noted previously by Scheerer and Betsch (1928–1929) [7], who had attributed this to the incorporation of eyes with crescent formation at the optic nerve. When these eyes were deleted from the data, a symmetric curve was obtained for the distribution of refraction. In the analysis of these data, it was pointed out that a positive excess persisted in the “corrected” curve. Stenstrom’s refractive curve [7] after the removal of eyes with crescent also demonstrated an excess. This central peaking was attributed to two factors: the first was the effect of the component correlation in the emmetropic range as postulated by Wibaut (1928) [5] and Berg (1931) [5] and the second was the direct effect of axial length distribution upon the curve of refraction [7]. Sorsby (1957) [9] later confirmed again the results of both Tron and Stenstrom and further explored the variables in the correlations between the optical components in various refractions. This had been done to a limited extent by Berg [5]. Sorsby and co-workers demonstrated conclusively in their study of 341 eyes the “emmetropization” effect that was noted in distribution curves of refraction as a result of a correlation of corneal power and axial length. In ametropia +4 D and above, this correlation appeared to break down. Their study also indicated that neither the lens nor the chamber depth was an effective emmetropization factor [2]. Gernet (1965) proposed the use of ultrasound to measure the ocular axial length [33] after ultrasonography was pioneered in ophthalmology by Mundt and Hughes in 1956 [34].

In 1887, Adolf Eugen Fick submitted a very original paper entitled “Eine Contactbrille” (A contact spectacle) to the Archiv für Augenheilkunde. This was a report on his work, which led to the development of contact lenses. He published his paper in 1888 and coined the term “contact lens” [35]. Fick designed glass contact lenses to correct myopia and irregular astigmatism using lenses that were specially ground by Abbe, of Jena [36]. There were many early contact lens designs, but the first one to allow circulation of tear film was made by Tuohy in 1948; the lens was made by plastic.

4 Recent Historical Landmarks in Myopia

There are many recent contributors to pathologic myopia. No work has influenced and inspired the eye care field more than the published comprehensive textbook on myopia in 1985 by Brian J. Curtin, M.D. [7] (Fig. 1.10): The Myopias: Basic Science and Clinical Management. It increased the evidence that pathologic myopia represented an important cause for severe vision loss worldwide, particularly in selected racial populations. Curtin’s textbook was an awakening on the importance of the disease and made clinical scientists to accelerate and intensify their research to expand our knowledge of the related embryological, epidemiological, molecular, biological, genetic, and clinical aspects of pathologic myopia. Curtin has many scientific contributions, and some of these will be briefly described here. Curtin and Karlin first used “lacquer cracks” and described the association between axial length and chorioretinal atrophy in 1970 [37]. In addition, Klein and Curtin discovered the formation of subretinal hemorrhage caused by lacquer cracks without choroidal neovascularization (CNV) in 1975 [38]. In 1977, Curtin created a classification scheme for staphyloma [39]. His textbook emphasized the importance of the posterior staphyloma which was incriminated in the clinical manifestations associated with severe visual decline. In addition, Curtin helped to identify the optic nerve as an important cause of visual changes in myopia and described the ocular changes putting myopic patients at risk for retinal detachment, early cataract formation, glaucoma, and a myriad of macular manifestations as its complications leading to severe vision loss [1].

Fig. 1.10
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Photograph of Brian Curtin, M.D.

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The other important figure is Tokoro, (Fig. 1.11), and some of his accomplishments will be mentioned here. Tokoro described the mechanism of axial elongation and chorioretinal atrophy in high myopia [40]. In 1988, Tokoro defined pathologic myopia [41], which has been used for many myopic studies. Afterward, Tokoro classified chorioretinal atrophy in the posterior pole in pathologic myopia as tessellated fundus, diffuse chorioretinal atrophy, small patch atrophy, and small macular hemorrhage [42].

Fig. 1.11
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Photograph of Takashi Tokoro, M.D.

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Some other recent landmarks in myopia were attributed to advanced technology and new treatments. Although fluorescein angiography (FA) is the main tool for diagnosing myopic CNV, indocyanine green angiography (ICGA) may better identify the CNV when large hemorrhages are present. ICGA also allows a better definition of lacquer cracks than FA [43, 44]. Optical coherence tomography (OCT) is a powerful real-time imaging modality. Since its introduction, it has been utilized in understanding the ocular structure in many eye diseases. In 1999, Takano and Kishi reported foveal retinoschisis and retinal detachment in severely myopic eyes with posterior staphyloma [45]. Three years later, Baba et al. first used OCT to demonstrate characteristic features at each stage of myopic CNV [46]. As for other findings investigated using OCT, Spaide invented enhanced depth imaging spectral domain OCT to obtain images of choroid [47] and found thinner choroids in highly myopic eyes [48]. Excessive thinning of the choroid eventually leads to chorioretinal atrophy. Ohno-Matsui and Moriyama have furthered our understanding of the shape of pathologically myopic eyes and posterior staphyloma using high-resolution 3D magnetic resonance images and ultrawide-field fundus photos [49,50,51]. With the advent of swept-source OCT (SS-OCT), structural changes in myopic eyes could be studied more clearly. Ohno-Matsui et al. described intrachoroidal cavitation using SS-OCT [52]. Recently, Dr. Ohno-Matsui and her group used ultrawide-field SS-OCT and found that the sites of posterior staphyloma and myopic macular retinoschisis are spatially related to each other in high myopic eyes [53]. In 2017, Jonas et al. hypothesized that axial elongation is caused by production of Bruch’s membrane in the retro-equatorial region, which plays an important role in myopization [54]. Because of potential of visual loss from myopic CNV, several treatments have been tried, for example, thermal laser photocoagulation [55] and photodynamic therapy (PDT) with Visudyne [56]. In 2005, Nguyen et al. reported the effectiveness of bevacizumab in treating CNV secondary to pathologic myopia. After that, ophthalmologists started to use anti-vascular endothelial growth factor to treat myopic CNV. Many details of diagnosis and treatment for myopic patients will be mentioned in later chapters.