Abstract
Here is presented, in chronological order, the studies that established the standards and determined the parameters currently considered for the safe use of anesthetic agents administered by intravenous or inhalation routes. The methods used in the experimental settings, as well as the modifications in the protocols to adapt to different clinical conditions, are described and discussed; The pharmacological criteria and the impact of these anesthetics on the cardiovascular and pulmonary systems are highlighted. However, additional information regarding the mechanisms of action of such agents is still needed, which would improve their use in terms of safety and efficacy.
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Ferrari, L.F., Arendt-Nielsen, L. (2023). Safety of Intravenous and Inhalation Anesthetics. In: Hock, F.J., Gralinski, M.R., Pugsley, M.K. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Cham. https://doi.org/10.1007/978-3-030-73317-9_68-1
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DOI: https://doi.org/10.1007/978-3-030-73317-9_68-1
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