Abstract
The checklist should provide a basis for the development of an individual treatment manual and standard operating procedures. Processes that already exist in the particular department and national guidelines can easily be integrated.
The development of a detailed treatment manual offers the possibility to reappraise familiar processes. Frequent changes of national and international guidelines – for example, guidelines for the transfusion of blood components, recommendations for perioperative nutritional support, or novel options for medical treatment of the underlying disease – should be checked regularly for modifications and amendments.
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1 Introduction
Definition of the area and time of application for this standard. | |
(Professions, departments, period) | |
Signature (Head of surgical department) | Signature (Head of anesthesiological department) |
2 Flowchart Treatment Algorithm
Adapt to the particular department.
3 Recent Clinical Trials
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TitleRegistration number
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Sponsor
4 Manual for Pre- and Postoperative Treatment
4.1 Tasks Prior to Admission
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Diagnostics
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Meticulous anamnesis
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Screening for multiresistant bacteria, COVID-19
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Contrast-enhanced CT scan thorax/abdomen/pelvis (PET/CT)
-
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Discussion in a GI tumor board
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Patient information
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Detailed information about the disease, options, prognosis, and risks of treatment
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Minimization of risk factors possible? Malnourishment? Cardiological/pulmonary/renal optimization possible?
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Schedules
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Malnourishment: enteral or parenteral supplementation for 7–10 days
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Specific perioperative treatment
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Order the perfusion equipment
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Order the chemotherapeutics
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Anesthesiological consultation
4.2 Day Before Surgery
Order the chemotherapeutics
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Exact definition – Who? What? When? How?
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Safety data sheets accessible?
General
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Check for completeness
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Tumor board recommendations?
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Involve hospital social services
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Offer psycho-oncological support
Diagnostics
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Optional if required
Laboratory values
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That is, CBC, electrolytes, AST/ALT, LDH, liver and renal function tests
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Tumor markers
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Blood group, transfusion request
Patient information
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Obtain informed consent for the planned operation and HIPEC.
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Obtain informed consent for enrolment in clinical trials, if applicable.
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Discuss the postoperative course and possible complications, ERAS.
Nutrition
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Liquid diet
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Routine bowel preparation
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In the case of motility disorders/ileus, parenteral nutrition: product, amount, infusion rate
DVT prophylaxis
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What? When? Dose?
Anesthesia
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Obtain informed consent for the planned operation and HIPEC.
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Obtain informed consent for enrolment in clinical trials, if applicable.
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Discuss the postoperative course and possible complications, ERAS.
4.3 Day of Surgery
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Check for completeness of required information and the plan of operative strategy
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Follow the regular standards and SOPs of the department
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Thoracic epidural: What? When? Dose?
Antibiotic prophylaxis
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What? When? Dose?
Antiemetic therapy
-
What? When? Dose?
Intraoperative measures
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SOP OR-nurse?
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SOP anesthetist and anesthesia nurse?
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SOP surgery?
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Recommendations for occupational health and safety available?
4.4 Day of Surgery ICU
Monitoring
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What? When? Interval?
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Vigilance CVP, results
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Ventilation, oxygenation
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Circulation
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Laboratory values
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Renal function/diuresis, core temperature, drained fluid balances
Circulation support
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What? When? Dose?
Diuresis
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Aim at ~1 ml/kgKG/h
Infusions
-
What? When? Dose?
Transfusions
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Aim at Hb 8 (−10) mg/dl
Analgesia
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Thoracic epidural: What? When? Dose?
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Without PDA: What? When? Dose?
Ventilation
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Strive for early extubation
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Spontaneous: O2 4 l/min via nasal probe, CPAP/NIV/HFNC
Nutrition
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What? When? Dose?
Antiemetic Therapy
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What? When? Dose?
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Intraoperative administration?
Mobilization
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Early mobilization according to ERAS recommendations
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Physiotherapeutic support
DVT prophylaxis
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What? When? Dose?
General
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Motivate the patient for active participation
Expect side effects
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Nausea, vomiting, diarrhea, fever
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SIRS
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Impaired vigilance
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Cardiac impairment, cardiac rhythm disorders
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Renal insufficiency
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Paralytic ileus
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Micturition disorders
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Reduction of immunologic competence
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Surgical complications (bleeding, anastomotic insufficiency)
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Pleural effusions
4.5 POD 1
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Center-specific postoperative monitoring and treatment
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For example……
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Strive for discharge from ICU
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Stabile circulation without inotropic support
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Sufficient spontaneous breathing, max 3lO2 via nasal probe
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Stabile renal function
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Efficient pain relief
-
-
Monitoring
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What? When? Interval?
-
-
Circulation support
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What? When? Dose?
-
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Diuresis
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Aim at ~1 ml/kgKG/h
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Infusions
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What? When? Dose?
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No basal infusion rate if possible
-
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Transfusions
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Aim at Hb 8 (−10) mg/dl
-
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Analgesia
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Thoracic epidural: What? When? Dose?
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Daily check for infection of the catheter insertion
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Without PDA: What? When? Dose?
-
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Ventilation
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Strive for early extubation
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Spontaneous: O2 4 l/min via nasal probe, CPAP/NIV/HFNC
-
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Nutrition
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What? When? Dose?
-
-
Antiemetic Therapy
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What? When? Dose?
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Intraoperative administration?
-
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Mobilization
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Early mobilization according to ERAS recommendations
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Physiotherapeutic support
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-
DVT prophylaxis
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What? When? Dose?
-
-
General
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Motivate the patient for active participation
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4.6 POD 2
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Strive for discharge from ICU
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Monitoring
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What? When? Interval?
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Circulation support
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What? When? Dose?
-
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Diuresis
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Aim at ~1 ml/kgKG/h
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If stable: remove bladder catheter
-
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Infusions
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What? When? Dose?
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No basal infusion rate if possible
-
-
Transfusions
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Aim at Hb 8 (−10) mg/dl
-
-
Analgesia
-
Thoracic epidural: What? When? Dose?
-
Daily check for infection of the catheter insertion
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Without PDA: What? When? Dose?
-
-
Ventilation
-
Strive for early extubation
-
Spontaneous: O2 4 l/min via nasal probe, CPAP/NIV/HFNC
-
-
Nutrition
-
What? When? Dose?
-
-
Antiemetic Therapy
-
What? When? Dose?
-
Intraoperative administration?
-
-
Mobilization
-
Early mobilization according to ERAS recommendations
-
Physiotherapeutic support
-
-
DVT prophylaxis
-
What? When? Dose?
-
-
General
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Motivate the patient for active participation
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Dressings
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Removal of abdominal drains (consult surgeon).
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Change wound and stoma dressings.
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4.7 POD 3
Strive for discharge from ICU
If a treatment on a normal peripheral ward is not achievable the further treatment on ICU should follow the regular ICU-SOPs with the aim of an early complete enteral nutrition and complete mobilization.
-
Monitoring
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What? When? Interval?
-
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Diuresis
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Aim at ~1 ml/kgKG/h
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If stable: remove bladder catheter
-
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Infusions
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What? When? Dose?
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No basal infusion rate if possible
-
-
Transfusions
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Aim at Hb 8 (−10) mg/dl
-
-
Analgesia
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Thoracic epidural: What? When? Dose?
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Daily check for infection of the catheter insertion
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Without PDA: What? When? Dose?
-
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Ventilation
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O2 max. 4 l/min via nasal probe, intermittent CPAP or intensive breathing exercises
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Nutrition
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What? When? Dose?
-
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Antiemetic Therapy
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What? When? Dose?
-
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Mobilization
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Early mobilization according to ERAS recommendations
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Physiotherapeutic support, walk on ward, 6–8 h out of bed
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DVT prophylaxis
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What? When? Dose?
-
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General
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Motivate the patient for active participation.
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Psycho-oncological support.
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Nutritional counseling.
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Dressings
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Removal of abdominal drains (consult surgeon).
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Change wound and stoma dressings.
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4.8 POD 4–7 or Normal Surgical Ward
Planning the discharge from hospital
Planning the discharge from hospital
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Hospital Social Service counseling
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Organization of ambulant wound and ostomy care
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Organization of ambulant psycho-oncological support
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Organization of palliative care or hospice if needed
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Criteria for discharge:
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Stabile vital functions
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Normal inflammation parameters
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Efficient pain relief
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Ensured ambulant treatment without interruption
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Widely independent participation in activities of daily living
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Intention of the patient
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Monitoring
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What? When? Interval?
Infusions
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What? When? Dose?
Transfusions
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Aim at Hb 8 (−10) mg/dl
Analgesia
-
What? When? Dose?
Ventilation
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Intensive breathing exercises
Nutrition
-
What? When? Dose?
Antiemetic Therapy
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What? When? Dose?
Mobilization
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Physiotherapeutic support, walk on ward, 6–8 h out of bed
DVT prophylaxis
-
What? When? Dose?
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Pause for removal of the epidural catheter if necessary
General
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Motivate the patient for active participation.
Dressings
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Removal of abdominal drains (consult surgeon).
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Change wound and stoma dressings.
5 Tasks After Discharge
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Check for histopathological report
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Tumor board counseling
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Removal of sutures/staples after 12 days, discussion of the definitive pathologic report
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Discussion and organization of the recommended tumor-specific therapy
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In case of splenectomy: vaccination according to national recommendations (pneumococcus, hemophilus, meningococcus, and seasonal influenza)
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Psycho-oncological counseling
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Definition of the follow-up
6 SOP Anesthesia Nursing
- Duration of surgery::
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~3–8 h
Special features
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Extensive measures for occupational safety reasons: safety glasses, special gloves, and scrubs
Patient positioning
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Lithotomy position
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Active temperature control
Preparation
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Venous access lines
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Arterial access line
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Thoracic epidural catheter
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Endotracheal intubation
Drugs
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What? When? Dose?
Monitoring
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ECG, blood pressure, SaO2
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CVP
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Intensive hemodynamic measurement (stroke volume, cardiac index)
7 SOP Anesthesia
Transfusion requirements
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Blood type, pRBC/FFP
Anesthesia
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TIVA with additional thoracic epidural analgesia
Drugs
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What? When? Dose?
Monitoring
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Internal standards/SOP
Induction
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Internal standards/SOP
Hemodynamic targets
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Mean arterial blood pressure MAP 60–70 mmHg
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Stroke volume variation SVV < 12%
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Cardiac index CI > 2.5
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Hb > 10 g/dl
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DO2 > 450 ml/min/m2
Intraoperative fluid administration:
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Crystalloids approx. 500 ml/h
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pRBC according to blood loss and targeted Hb
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FFP in case of massive bleeding or coagulopathy
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(Colloids according to internal standards)
Criteria for hypovolemia/vasopressors
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Internal standards/SOP
Criteria for inotropic support with dobutamine or enoximone
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Internal standards/SOP
Active temperature control
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During CRS: core/bladder >36 °C
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During HIPEC: arterial <38 °C
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During HIPEC: abdominal: 42 °C (cave >42.5 °C)
Renal function
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Awareness for nephrotoxic chemotherapeutics, abdominal hypertensive, impaired renal blood flow, and possible extensive fluid shifts during HIPEC
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Diuresis at least 1 ml/kg/h
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Avoid hypovolemia
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In case of oliguria or hypervolemia high-ceiling diuretics
Antiemetic therapy
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Internal standards/SOP
Postoperative management
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Planned extubation at the ICU
8 SOP Surgery
Detailed standard operating procedures and internal guidelines should be developed for at least the following issues:
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Preoperative aspects (patient selection, preparation for surgery, anesthesiological management)
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Typical surgical techniques and techniques for CRS
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General surgical principles for frequently applied resection steps (i.e., oncologically adequate colonic resection, techniques of anastomotic formation, chest tube insertion, techniques of fascia closure, etc.)
9 Histopathologic Workup
The pathologic report should describe the basic oncologic findings (assessment, staging). Additional examinations should be possible and follow the (molecular) tumor board counseling.
Additional aspects in cases of colorectal carcinoma
That is, MSI, all-RAS, BRAF
Additional aspects in cases of gastric carcinoma
That is, HER2/neu expression
Additional aspects in cases of mucinous appendix neoplasm
Proliferation index
10 Preparation for CRS/HIPEC
HIPEC techique (open/closed) | |
---|---|
Diagnosis | |
Indication | |
Operating table | |
Patient positioning | |
Auxiliary positioning devices | |
Electrical instruments | |
Trays | |
Retractor systems | |
Trays in standby | |
Drapes | |
Scrubs | |
Sutures | |
Drains | |
Additional | |
Notes | |
Safety features |
11 Occupational Health and Safety
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Annual education and training on safety aspects during HIPEC.
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The OR should be indicated using warning signs.
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Only absolutely essential staff should enter the OR during HIPEC.
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Personal safety equipment should be used.
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Excretions are potentially contaminated for up to 24 h depending on the chemotherapeutic drug.
Measures in case of surrounding contamination
Internal standards/SOP
Measures in case of contamination of the personnel
Internal standards/SOP
12 Checklist for the Use of Chemotherapeutics for HIPEC
What | Note | Check |
---|---|---|
Warning signs Caution! Chemotherapy/biohazard Contact staff before entering the OR | On site? Attached to all entries of the OR? | □ □ |
Impermeable laundry bags | On site? | □ |
Safety glasses with lateral protection | On site? | □ |
Impermeable scrubs | On site? | □ |
Chemoresistant sterile gloves | On site? | □ |
Chemoresistant unsterile gloves | On site? | □ |
Chemotherapeutic drugs | On site? | □ |
Chemotherapy waste containers | On site? | □ |
Spill kit | On site? | □ |
Date: Signature:
13 Chemotherapeutic Regimen for HIPEC
Origin | Chemotherapeutics center specific |
Colorectal | i.p.: mitomycin C 30 mg/m2 90 min (Cisplatin 100 mg/m2) |
Appendiceal | i.p.: mitomycin C 30 mg/m2 90 min (Cisplatin 100 mg/m2) |
Pseudomyxoma | i.p.: mitomycin C 30 mg/m2 90 min (Cisplatin 100 mg/m2) |
Ovarian | i.p.: cisplatin 75 mg/m2 + doxorubicin 15 mg/m2 90 min |
Gastric | i.p.: cisplatin 75 mg/m2 + doxorubicin 15 mg/m2 90 min |
Mesothelioma | i.p.: cisplatin 75 mg/m2 + doxorubicin 15 mg/m2 90 min |
-
Carrier solution: NaCl 0.9%
-
Mitomycin C should be given in three doses for 30 min each, due to its short half-life.
14 PCI Assessment
0 | Central | 7 | Right lower |
1 | Right upper | 8 | Right flank |
2 | Epigastrium | 9 | Upper jejunum |
3 | Left upper | 10 | Lower jejunum |
4 | Left flank | 11 | Upper ileum |
5 | Left lower | 12 | Lower ileum |
6 | Pelvis |
15 Information Material for the Anesthetist
Preparation and intraoperative management
-
Internal standards/SOP
Severe fluid shifts and coagulation disorders are to be expected due to extensive wound surfaces and the duration of the complete procedure.
Frequent postoperative complications or side effects
-
Nausea, vomiting, diarrhea, fever
-
SIRS
-
Impaired vigilance
-
Cardiac impairment, cardiac rhythm disorders
-
Renal insufficiency
-
Paralytic ileus
-
Micturition disorders
-
Reduction of immunologic competence
-
Surgical complications (bleeding, anastomotic insufficiency)
16 Checklist for Outpatient Department
Ordered | Executed | |
---|---|---|
Documentation of bodyweight and height | □ | □ |
Tumor board counseling | □ | □ |
Information material for surgery delivered | □ | □ |
Information material for chemo/HIPEC delivered | □ | □ |
Consent for transfusions delivered | □ | □ |
Check for participation in trials | □ | □ |
Fix a date for anesthesiological counseling | □ | □ |
Fix a date for further diagnostics | □ | □ |
Fix a date for CRS/HIPEC | □ | □ |
17 Checklist Surgical Ward
Ordered | Executed | |
---|---|---|
Detailed anamnesis and examination | □ | □ |
Preparation for surgery | ||
Blood type + pRBCs | □ | □ |
Bowel preparation | □ | □ |
⋯ | □ | □ |
Intraoperative antibiotics | ||
Drug 1 | □ | □ |
Drug 2 | □ | □ |
Others… | □ | □ |
Intraoperative antiemetics | ||
Drug 1 | □ | □ |
Drug 2 | □ | □ |
Drug 3 | □ | □ |
DVT prophylaxis | ||
Drug 1 | □ | □ |
Compression devices | □ | □ |
Others… | □ | □ |
Final check | ||
Documents complete? | □ | |
Tumor board counseling | □ | |
Counseling the hospital social service team | □ | |
Psycho-oncological counseling | □ |
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Raue, W., Kilian, M., Brandl, A., Rau, B. (2021). Checklists for the Treatment of Tumors of the Peritoneum: Framework SOP. In: Rau, B., Königsrainer, A., Mohamed, F., Sugarbaker, P.H. (eds) Peritoneal Tumors and Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-62640-2_46
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