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A Brief Introduction to Tiling Microarrays: Principles, Concepts, and Applications

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Tiling Arrays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1067))

Abstract

Technological achievements have always contributed to the advancement of biomedical research. It has never been more so than in recent times, when the development and application of innovative cutting-edge technologies have transformed biology into a data-rich quantitative science. This stunning revolution in biology primarily ensued from the emergence of microarrays over two decades ago. The completion of whole-genome sequencing projects and the advance in microarray manufacturing technologies enabled the development of tiling microarrays, which gave unprecedented genomic coverage. Since their first description, several types of application of tiling arrays have emerged, each aiming to tackle a different biological problem. Although numerous algorithms have already been developed to analyze microarray data, new method development is still needed not only for better performance but also for integration of available microarray data sets, which without doubt constitute one of the largest collections of biological data ever generated. In this chapter we first introduce the principles behind the emergence and the development of tiling microarrays, and then discuss with some examples how they are used to investigate different biological problems.

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Acknowledgements

This work was supported by an NIH grant (5R00LM009770-06) from the National Library of Medicine to Z.D.Z.

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Authors and Affiliations

  1. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA

    Christophe Lemetre & Zhengdong D. Zhang

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  1. Christophe Lemetre
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  2. Zhengdong D. Zhang
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Editors and Affiliations

  1. Rm 624A Area 39, The Chinese University of Hong Kong Reproduction, Development and Endocrinol, Hong Kong, China, People's Republic

    Tin-Lap Lee

  2. Rm 624A Area 39, The Chinese University of Hong Kong Reproduction, Development and Endocrinol, Hong Kong, China, People's Republic

    Alfred Chun Shui Luk

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Lemetre, C., Zhang, Z.D. (2013). A Brief Introduction to Tiling Microarrays: Principles, Concepts, and Applications. In: Lee, TL., Shui Luk, A. (eds) Tiling Arrays. Methods in Molecular Biology, vol 1067. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-607-8_1

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  • DOI: https://doi.org/10.1007/978-1-62703-607-8_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-606-1

  • Online ISBN: 978-1-62703-607-8

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