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Fullerenol Nanoparticles: Toxicity and Antioxidant Activity

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Oxidative Stress and Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1028))

Abstract

Fullerenes are a relatively new group of compounds and represent a class of sphere-shaped molecules made exclusively of carbon atoms. Since their discovery in 1985, many aspects of both fullerene and its analogues have been intensively studied to reveal their physical and chemical reactivity, as well as potential use in biological systems. Both in vitro and in vivo studies have shown that polyhydroxylated fullerene derivatives, fullerenol nanoform (C60(OH) n , n = 2–72), can be potential antioxidative agents in biological systems. This chapter represents a review of published studies of fullerenes’ biological activities with special accent on the most tested fullerenol nanoform C60(OH)24.

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Acknowledgment

This work received partial financial support from the Slovenian Research Agency, Ljubljana, Slovenia, grant No.: P4-0127.

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Authors and Affiliations

  1. Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

    Rade Injac, Matevz Prijatelj & Borut Strukelj

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  1. Rade Injac
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  2. Matevz Prijatelj
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  3. Borut Strukelj
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Editors and Affiliations

  1. University of Florida, n/a, Gainsville, 32611, Florida, USA

    Donald Armstrong

  2. , Pharmaceutical Research Institute, Albany College of Pharmacy, Discovery Lane 1, Rensselaer, 12144, USA

    Dhruba J Bharali

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Injac, R., Prijatelj, M., Strukelj, B. (2013). Fullerenol Nanoparticles: Toxicity and Antioxidant Activity. In: Armstrong, D., Bharali, D. (eds) Oxidative Stress and Nanotechnology. Methods in Molecular Biology, vol 1028. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-475-3_5

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  • DOI: https://doi.org/10.1007/978-1-62703-475-3_5

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-474-6

  • Online ISBN: 978-1-62703-475-3

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