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Experimental Traumatic Spinal Cord Injury

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Tissue-Protective Cytokines

Part of the book series: Methods in Molecular Biology ((MIMB,volume 982))

Abstract

Animal models are important to develope therapies for individuals suffering from spinal cord injuries. For this purpose, rats are commonly preferred. In sharp injury models, spinal cord is completely or incompletely cut to assess axonal regeneration. On the other hand, spinal cord is compressed or contused to mimic the human injury in blunt injury models for understanding as well as managing the secondary pathophysiologic processes following injury. Especially, contusions are thought to be biomechanically similar to vertebral fractures and/or dislocations and thus provide the most realistic experimental setting in which to test potential neuroprotective and regenerative strategies.

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Author information

Authors and Affiliations

  1. Department of Medical Biochemistry, School of Medicine, Dokuz Eylul University, İnciralti, İzmir, Turkey

    Zübeyde Erbayraktar

  2. DEpartment of Anesthesia and Reanimation, School of Medicine, Dokuz Eylul University, İnciralti, İzmir, Turkey

    Necati Gökmen

  3. Animal Research Center, School of Medicine, Dokuz Eylul University, İnciralti, İzmir, Turkey

    Osman Yılmaz

  4. Department of Neurosurgery, School of Medicine, Dokuz Eylul University, İnciralti, İzmir, Turkey

    Serhat Erbayraktar

Authors
  1. Zübeyde Erbayraktar
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  2. Necati Gökmen
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  3. Osman Yılmaz
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  4. Serhat Erbayraktar
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Editor information

Editors and Affiliations

  1. Medical School, Brighton and Sussex, Trafford Centre, Falmer, BN1 9RY, United Kingdom

    Pietro Ghezzi

  2. Leiden University Medical Center, Stille Rijn 11a, Leiden, 2312 DE, Netherlands

    Anthony Cerami

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Erbayraktar, Z., Gökmen, N., Yılmaz, O., Erbayraktar, S. (2013). Experimental Traumatic Spinal Cord Injury. In: Ghezzi, P., Cerami, A. (eds) Tissue-Protective Cytokines. Methods in Molecular Biology, vol 982. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-308-4_6

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  • DOI: https://doi.org/10.1007/978-1-62703-308-4_6

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-307-7

  • Online ISBN: 978-1-62703-308-4

  • eBook Packages: Springer Protocols

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