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Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

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Animal Models of Spinal Cord Repair

Part of the book series: Neuromethods ((NM,volume 76))

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Abstract

This chapter reflects the yearning for discoveries within the field of spinal cord injury (SCI) and points out the difficulties, opportunities, as well as possibilities to relate and translate the results from basic science to clinical management. After a brief presentation of “spinal cord history,” we provide a short overview of the cornerstones of modern management of patients with SCI. This overview will, besides introducing basic scientists in the field of clinical practice, also expose the inherent imprecision of everyday clinical care compared to the high methodological requirements of experimental SCI research. We will focus our presentation on medical management aimed at preventing the consequences of secondary injury in the acute period, i.e., neuroprotection. A brief overview of various techniques of neural regeneration in the subacute (late) and chronic phase will follow this. Finally, based on the progress in basic science within the fields of neuroprotection and regeneration, some thoughts about future clinical therapeutic avenues will be discussed.

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Authors and Affiliations

  1. Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden

    Anders Holtz

  2. Department of Clinical Science, Neurosurgery, Lund University, Lund, Sweden

    Leif Anderberg

  3. Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden

    Shala Ghaderi Berntsson

  4. Department of Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden

    Håkan Aldskogius

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  1. Anders Holtz
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  2. Leif Anderberg
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  3. Shala Ghaderi Berntsson
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  4. Håkan Aldskogius
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Correspondence to Anders Holtz .

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Editors and Affiliations

  1. Biomedical Center, Department of Neuroscience, Uppsala University, Husargatan 3, Uppsala, 751 24, Sweden

    Håkan Aldskogius

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Holtz, A., Anderberg, L., Berntsson, S.G., Aldskogius, H. (2013). Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science. In: Aldskogius, H. (eds) Animal Models of Spinal Cord Repair. Neuromethods, vol 76. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-197-4_14

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  • DOI: https://doi.org/10.1007/978-1-62703-197-4_14

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-196-7

  • Online ISBN: 978-1-62703-197-4

  • eBook Packages: Springer Protocols

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