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Secondary Insults in Experimental Traumatic Brain Injury: The Addition of Hypoxia

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Animal Models of Neurotrauma

Part of the book series: Neuromethods ((NM,volume 149))

Abstract

Traumatic brain injury (TBI), with its secondary injury development, is the most common cause of death and disability among the young. One of the most frequent secondary insults that TBI patients suffer from is hypoxia, which could be due to obstructed airways at the scene of accident, injury to associated blood vessels, or thoracic injuries. Systemic hypoxia following TBI has been seen to lead to an increased neuronal death, a more detrimental neuroinflammatory response, and an unfavorable outcome. This condition may be mimicked in experimental TBI conditions where oxygen delivery is strictly controlled. In order to succeed in these types of experiments, monitoring of physiological parameters is paramount and in order to validate hypoxic conditions, peripheral oxygen saturation, O2 pressure (pO2) in the blood, or fraction of inhaled O2 (FiO2) could be used as goals. Different models of experimental TBI may be used to inflict the preferred injury type and the desired effects could then be assessed using radiological, physiological, biological and functional tests.

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Acknowledgments

The authors would like to thank Sophie Ankarcrona for her help with the language revision of the text.

Author information

Authors and Affiliations

  1. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Caroline Lindblad & Eric Peter Thelin

  2. Theme Neuro, Karolinska University Hospital, Stockholm, Sweden

    Eric Peter Thelin

Authors
  1. Caroline Lindblad
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  2. Eric Peter Thelin
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Corresponding author

Correspondence to Eric Peter Thelin .

Editor information

Editors and Affiliations

  1. Experimental Traumatology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Mårten Risling

  2. Division of Vehicle Safety, Department of Mechanics and Maritime Sciences, Chalmers University of Technology, Gothenburg, Sweden

    Johan Davidsson

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Lindblad, C., Thelin, E.P. (2019). Secondary Insults in Experimental Traumatic Brain Injury: The Addition of Hypoxia. In: Risling, M., Davidsson, J. (eds) Animal Models of Neurotrauma. Neuromethods, vol 149. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9711-4_13

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  • DOI: https://doi.org/10.1007/978-1-4939-9711-4_13

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9709-1

  • Online ISBN: 978-1-4939-9711-4

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