Abstract
Metastases are the most common tumor type to affect the adult central nervous system. In vivo modeling of brain metastases provides insight into the mechanisms of metastatic development as well as a clinically relevant therapeutic screening platform. Here we describe the development of a novel mouse model of brain metastasis from a primary lung cancer utilizing primary patient samples. These models provide an accurate representation of different stages of the clinical progression of the disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Patchell RA (2003) The management of brain metastases. Cancer Treat Rev 29:533–540
Arvelo F, Sojo F, Cotte C (2016) Tumor progression and metastasis. Ecancermedicalscience 10:617. https://doi.org/10.3332/ecancer.2016.617
Singh M, Manoranjan B, Mahendram S, McFarlane N, Venugopal C, Singh SK (2014) Brain metastasis-initiating cells: survival of the fittest. Int J Mol Sci 15:9117–9133. https://doi.org/10.3390/ijms15059117
Liao WT, Ye YP, Deng YJ, Bian XW, Ding YQ (2014) Metastatic cancer stem cells: from the concept to therapeutics. Am J Stem Cells 3:46–62
Bos PD, Nguyen DX, Massague J (2010) Modeling metastasis in the mouse. Curr Opin Pharmacol 10:571–577. https://doi.org/10.1016/j.coph.2010.06.003
Daphu I, Sundstrom T, Horn S, Huszthy PC, Niclou SP, Sakariassen PO, Immervoll H, Miletic H, Bjerkvig R, Thorsen F (2013) In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis 30:695–710. https://doi.org/10.1007/s10585-013-9566-9
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Singh, M., Savage, N., Singh, S.K. (2019). In Vivo Murine Models of Brain Metastasis. In: Singh, S., Venugopal, C. (eds) Brain Tumor Stem Cells. Methods in Molecular Biology, vol 1869. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8805-1_19
Download citation
DOI: https://doi.org/10.1007/978-1-4939-8805-1_19
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-8804-4
Online ISBN: 978-1-4939-8805-1
eBook Packages: Springer Protocols