Abstract
Cerenkov luminescence imaging (CLI) is a relatively new imaging modality that utilizes conventional optical imaging instrumentation to detect Cerenkov radiation derived from standard and often clinically approved radiotracers. Its research versatility, low cost, and ease of use have increased its popularity within the molecular imaging community and at institutions that are interested in conducting radiotracer-based molecular imaging research, but that lack the necessary resources and infrastructure. Here, we provide a description of the materials and procedures necessary to conduct a Cerenkov luminescence imaging experiment using a variety of imaging instrumentation, radionuclides, and animal models.
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Acknowledgments
This work was supported by NIH grant NIH P30 CA012197, DoD grant W81XWH-13-1-0125, and The United States Department of Energy Office of Science-Isotope Program in the Office of Nuclear Physics.
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Bhatt, N.B. et al. (2018). Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes. In: Dubey, P. (eds) Reporter Gene Imaging. Methods in Molecular Biology, vol 1790. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7860-1_15
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DOI: https://doi.org/10.1007/978-1-4939-7860-1_15
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