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Chromothripsis and the Macroevolution Theory

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Chromothripsis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1769))

Abstract

The recent discovery of a new class of massive chromosomal rearrangements, occurring during one unique cellular event and baptized “chromothripsis,” deeply modifies our perception on the genesis of complex genomic rearrangements, but also it raises the question of the potential driving role of chromothripsis in species evolution. The occurrence of chromothripsis appears to be in good agreement with macroevolution models proposed as a complement to phyletic gradualism. The emergence of this unexpected phenomenon may help to demonstrate the contribution of chromosome rearrangements to speciation process.

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Acknowledgments

Work in the unit of Chromosomal Genetics is supported by the CHU research platform ChromoStem (http://www.chu-montpellier.fr/fr/chercheurs/plateformes/les-plateformes-recherche/chromostem/).

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Authors and Affiliations

  1. Unit of Chromosomal Genetics, Department of Medical Genetics, Arnaud de Villeneuve Hospital, Montpellier CHRU, Montpellier, France

    Franck Pellestor

  2. INSERM U1183 Unit “Genome and Stem Cell Plasticity in Development and Ageing”, Institute for Regenerative Medicine and Biotherapy, St Eloi Hospital, Montpellier, France

    Franck Pellestor

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  1. Franck Pellestor
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Correspondence to Franck Pellestor .

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Editors and Affiliations

  1. Unit of Chromosomal Genetics, Department of Medical Genetics, CHU Montpellier, Montpellier, Hérault, France

    Franck Pellestor

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Pellestor, F. (2018). Chromothripsis and the Macroevolution Theory. In: Pellestor, F. (eds) Chromothripsis. Methods in Molecular Biology, vol 1769. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7780-2_4

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  • DOI: https://doi.org/10.1007/978-1-4939-7780-2_4

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7779-6

  • Online ISBN: 978-1-4939-7780-2

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