Abstract
Carotid bodies are sensory organs for monitoring chemical composition of the arterial blood, especially the O2 levels. Carotid bodies are located bilaterally at the bifurcation of the common carotid artery. Hypoxia increases sensory nerve activity of the carotid body, which is transmitted to the brainstem neurons triggering reflex stimulation of breathing and blood pressure. Measurement of action potentials from the carotid sinus nerve is a widely used approach for understanding the mechanisms of hypoxic sensing by the carotid body. Here, we describe the detailed methodology for recording action potential signals from the carotid sinus nerve from in vivo and ex vivo carotid bodies from rats.
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Acknowledgments
This work was supported by National Institutes of Health grant PO1-HL- 90554.
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Peng, YJ., Prabhakar, N.R. (2018). Measurement of Sensory Nerve Activity from the Carotid Body. In: Huang, L. (eds) Hypoxia. Methods in Molecular Biology, vol 1742. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7665-2_11
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DOI: https://doi.org/10.1007/978-1-4939-7665-2_11
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7664-5
Online ISBN: 978-1-4939-7665-2
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