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A Combinatorial Approach to Circuit Mapping in the Mouse Olfactory Bulb

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Extracellular Recording Approaches

Part of the book series: Neuromethods ((NM,volume 134))

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Abstract

Neurons form neural circuits through functional synapses. Inputs and outputs across these circuits contribute to the brain’s intricate mechanisms of information processing and behavioral responses. By combining acousto-optic deflector-based scanning microscopy with optogenetics, whole cell electrophysiological recordings, and transgenic viral delivery, researchers can now investigate and map relevant neural circuits with high spatial and cell type-specific precision. The goal of this review is to provide the reader with guidelines and methods for using a combinatorial approach toward circuit mapping in rodent brain tissue.

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Acknowledgments

This research was supported by funding from the McNair Medical Institute and NINDS grant R01NS078294.

Author information

Authors and Affiliations

  1. Program in Developmental Biology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, USA

    Gary Liu, Kevin Ung, Burak Tepe & Benjamin R. Arenkiel

  2. Department of Molecular & Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, USA

    Jessica Swanson, Brandon Pekarek, Sugi Panneerselvam & Benjamin R. Arenkiel

  3. Department of Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, USA

    Longwen Huang & Benjamin R. Arenkiel

Authors
  1. Gary Liu
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  2. Jessica Swanson
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  3. Brandon Pekarek
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  4. Sugi Panneerselvam
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  5. Kevin Ung
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  6. Burak Tepe
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  7. Longwen Huang
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  8. Benjamin R. Arenkiel
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Corresponding author

Correspondence to Benjamin R. Arenkiel .

Editor information

Editors and Affiliations

  1. Department of Pathology & Immunology and Neuroscience, Baylor College of Medicine, Houston, Texas, USA

    Roy V. Sillitoe

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Liu, G. et al. (2018). A Combinatorial Approach to Circuit Mapping in the Mouse Olfactory Bulb. In: Sillitoe, R. (eds) Extracellular Recording Approaches. Neuromethods, vol 134. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7549-5_7

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  • DOI: https://doi.org/10.1007/978-1-4939-7549-5_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7548-8

  • Online ISBN: 978-1-4939-7549-5

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