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Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies

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Vaccines for Invasive Fungal Infections

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1625))

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Abstract

As implied by the idiotypic network theory, the interaction between the functional epitope of a microbicidal molecule (X) and its specific cell-wall receptor (RX) on sensitive microorganisms may be imaged by the bond between the idiotype (Id) of a neutralizing monoclonal antibody (anti-X Ab) and its anti-idiotype (anti-Id) X-like Ab (anti-anti-X Ab). Consequently, anti-X Ab Id may mimic RX acting as a vaccine (idiotypic vaccination) for the elicitation of protective anti-Id Abs with antibiotic activity (antibiobodies).

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Authors and Affiliations

  1. Unit of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, Italy

    Luciano Polonelli, Walter Magliani & Stefania Conti

Authors
  1. Luciano Polonelli
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  2. Walter Magliani
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  3. Stefania Conti
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Corresponding author

Correspondence to Luciano Polonelli .

Editor information

Editors and Affiliations

  1. Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, California, USA

    Markus Kalkum

  2. Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, California, USA

    Margarita Semis

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Polonelli, L., Magliani, W., Conti, S. (2017). Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies. In: Kalkum, M., Semis, M. (eds) Vaccines for Invasive Fungal Infections. Methods in Molecular Biology, vol 1625. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7104-6_8

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  • DOI: https://doi.org/10.1007/978-1-4939-7104-6_8

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7103-9

  • Online ISBN: 978-1-4939-7104-6

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