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Role of Tumor-Stromal Interactions in Pancreatic Cancer Invasion and Metastases

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Pancreatic Cancer

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Abstract

Pancreatic cancer tumor microenvironment (TME), simply defined as the noncancerous desmoplastic reaction, is considered a key player in all aspects of tumor growth, and progression. The dismal prognosis of pancreatic cancer and disappointing clinical trials has drawn our attention to the TME, particularly to the tumor-stromal interactions. While a myriad of molecular, pathological, and clinical features contribute to the lethality of pancreatic cancer, local invasiveness and distant metastases is a hallmark and leading cause of mortality and morbidity in this ominous cancer. Cancer-associated stromal cells including stellate cells have been implicated in epithelial mesenchymal transition (EMT), a process involved in invasion and metastases. In addition, the pre-metastatic niche, immune evasion, and enhancement of angiogenesis have been attributed to these cells. Interactions of the tumor stromal complex operate as a command and logistics center for pancreatic cancer cells, triggering and maintaining invasiveness and metastases. Understanding and modulating these interactions is a promising strategy to tame one of the most aggressive human cancers to date.

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Acknowledgment

We would like to acknowledge the contributions of the authors of the excellent research studies and comprehensive reviews that were cited herein. We apologize to any authors whose work we omitted due to space limitations. We are grateful to Mohamed Mohameden Ibrahim Elamir for his unwavering support, and motivation. This work was supported by the NIH/NCI CA136526, Mayo Clinic Pancreatic SPORE P50 CA102701, and Mayo Clinic Center for Cell Signaling in Gastroenterology P30 DK84567 and Mayo Clinic Cancer.

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Authors and Affiliations

  1. Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA

    Rachel L. O. Olson, Judith V. Forner & Martin E. Fernandez-Zapico

  2. Center for Learning Innovation, University of Minnesota Rochester, Rochester, MN, USA

    Rachel L. O. Olson

  3. Cancer Research Programme, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain

    Judith V. Forner & Pilar Navarro

  4. Clinical Oncology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

    Ahmed M. Elamir

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  1. Rachel L. O. Olson
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  2. Judith V. Forner
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  3. Pilar Navarro
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  5. Ahmed M. Elamir
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Correspondence to Ahmed M. Elamir .

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Editors and Affiliations

  1. Department of General Surgery, University Hospital Heidelberg Department of General Surgery, Heidelberg, Germany

    John Neoptolemos

  2. Rochester, Minnesota, USA

    Raul Urrutia

  3. Dept. Gastrointestinal Medical Onco, Duke University Medical Center Dept. Gastrointestinal Medical Onco, Durham, North Carolina, USA

    James Abbruzzese

  4. Heidelberg, Germany

    Markus W. Büchler

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Olson, R.L.O., Forner, J.V., Navarro, P., Fernandez-Zapico, M.E., Elamir, A.M. (2018). Role of Tumor-Stromal Interactions in Pancreatic Cancer Invasion and Metastases. In: Neoptolemos, J., Urrutia, R., Abbruzzese, J., Büchler, M. (eds) Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6631-8_89-1

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  • Print ISBN: 978-1-4939-6631-8

  • Online ISBN: 978-1-4939-6631-8

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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