Abstract
Systems biology is an approach to study all genes, gene transcripts, proteins, metabolites, and their interactions in specific cells, tissues, organs, or the whole organism. It is based on data derived from high-throughput analytical technologies and bioinformatics tools to analyze these data, and aims to understand the whole system rather than individual aspects of it. Systems biology can be applied to virtually all conditions and diseases and therefore also to hypertension and its underlying vascular disorders. Unlike other methods in this book there is no clear-cut protocol to explain a systems biology approach. We will instead outline some of the most important and common steps in the generation and analysis of systems biology data.
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Acknowledgments
Work in our laboratory is supported by grants from the European Union (“EU-MASCARA,” grant agreement 278249; and “PRIORITY,” grant agreement 279277) and by the Scottish Government (Strategic Research Development Grant “Biomarkers for Battling Chronic Disease”).
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Delles, C., Husi, H. (2017). Systems Biology Approach in Hypertension Research. In: Touyz, R., Schiffrin, E. (eds) Hypertension. Methods in Molecular Biology, vol 1527. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6625-7_6
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DOI: https://doi.org/10.1007/978-1-4939-6625-7_6
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Publisher Name: Humana Press, New York, NY
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