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The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation

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T-Cell Differentiation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1514))

Abstract

The T cell receptor confers specificity for antigen recognition to T cells. By the first encounter with the cognate antigen, reactive T cells initiate a program of expansion and differentiation that will define not only the ultimate quantity of specific cells that will be generated, but more importantly their quality and functional heterogeneity. Recent achievements using mouse model infection systems have helped to shed light into the complex network of factors that dictate and sustain memory T cell differentiation, ranging from antigen load, TCR signal strength, metabolic fitness, transcriptional programs, and proliferative potential. The different models of memory T cell differentiation are discussed in this chapter, and key phenotypic and functional attributes of memory T cell subsets are presented, both for mouse and human cells. Therapeutic manipulation of memory T cell generation is expected to provide novel unique ways to optimize current immunotherapies, both in infection and cancer.

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Authors and Affiliations

  1. Translational Tumor Immunology Group, Ludwig Cancer Research Center, University of Lausanne, Biopole III, CB02, Chemin des Boveresses 155, 1066, Epalinges, Switzerland

    Camilla Jandus, Amaia Martínez Usatorre, Selena Viganò, Lianjun Zhang & Pedro Romero

Authors
  1. Camilla Jandus
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  2. Amaia Martínez Usatorre
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  3. Selena Viganò
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  4. Lianjun Zhang
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  5. Pedro Romero
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Corresponding author

Correspondence to Pedro Romero .

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Editors and Affiliations

  1. Laboratory of Translational Immunology, Humanitas Clinical & Research Center, Rozzano, Italy

    Enrico Lugli

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Jandus, C., Usatorre, A.M., Viganò, S., Zhang, L., Romero, P. (2017). The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation. In: Lugli, E. (eds) T-Cell Differentiation. Methods in Molecular Biology, vol 1514. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6548-9_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6548-9_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6546-5

  • Online ISBN: 978-1-4939-6548-9

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