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Structural Basis of Protein-Protein Interactions

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Protein-Protein Interactions

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1278))

Abstract

Regulated interactions between proteins govern signaling pathways within and between cells. Structural studies on protein complexes formed reversibly and/or transiently illustrate the remarkable diversity of interactions, both in terms of interfacial size and nature. In recent years, “domain–peptide” interactions have gained much greater recognition and may be viewed as both pre-translational and posttranslational-dependent functional switches. Our understanding of the multistep regulation of auto-inhibited multidomain proteins has also grown. Their activity may be understood as the “combinatorial” output of multiple input signals, including phosphorylation, location, and mechanical force. The prospects for bridging the gap between the new “systems biology” data and the traditional “reductionist” data are also discussed.

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Authors and Affiliations

  1. Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Robert C. Liddington

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  1. Robert C. Liddington
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Correspondence to Robert C. Liddington .

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Editors and Affiliations

  1. Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA

    Cheryl L. Meyerkord

  2. Department of Pharmacology, Department of Hematology & Medical Oncology, and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, USA

    Haian Fu

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Liddington, R.C. (2015). Structural Basis of Protein-Protein Interactions. In: Meyerkord, C., Fu, H. (eds) Protein-Protein Interactions. Methods in Molecular Biology, vol 1278. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2425-7_1

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  • DOI: https://doi.org/10.1007/978-1-4939-2425-7_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2424-0

  • Online ISBN: 978-1-4939-2425-7

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