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Paradigm Shifts in Mast Cell and Basophil Biology and Function: An Emerging View of Immune Regulation in Health and Disease

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Basophils and Mast Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1192))

Abstract

The physiological role of the mast cell and basophil has for many years remained enigmatic. In this chapter we briefly summarize some of the more recent studies that shed new light on the role of mast cells and basophils in health and disease. What we gain from these studies is a new appreciation for mast cells and basophils as sentinels in host defense and a further understanding that dysregulation of mast cell and basophil function can be a component of various diseases other than allergies. Perhaps, the most important insight reaped from this work is the increasing awareness that mast cells and basophils can function as immunoregulatory cells that modulate the immune response in health and disease. Collectively, the recent knowledge provides new challenges and opportunities towards the development of novel therapeutic strategies to augment host protection and modify disease through manipulation of mast cell and basophil function.

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Authors and Affiliations

  1. Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building: 10, Room: 13C205, 10 Center Drive, Bethesda, MD, 20892, USA

    Ana Olivera

  2. Molecular Immunology Section, Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building: 10, Room: 13C103B, 10 Center Drive, Bethesda, MD, 20892, USA

    Juan Rivera

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  1. Ana Olivera
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Editors and Affiliations

  1. Medway School of Pharmacy, The University of Kent, Chatham Maritime, Kent, United Kingdom

    Bernhard F. Gibbs

  2. Division of Molecular and Cellular Science, The School of Pharmacy, The University of Nottingham, Nottingham, United Kingdom

    Franco H. Falcone

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Olivera, A., Rivera, J. (2014). Paradigm Shifts in Mast Cell and Basophil Biology and Function: An Emerging View of Immune Regulation in Health and Disease. In: Gibbs, B., Falcone, F. (eds) Basophils and Mast Cells. Methods in Molecular Biology, vol 1192. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1173-8_1

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