Abstract
Cerebrovascular disease (CVD) is a general term encompassing all the brain abnormalities that result from pathologies of its blood vessels (e.g., atherosclerotic, aneurysm, inflammation, dissection). CVD can manifest as an acute onset or chronic condition and can affect any part of the central nervous system, including the spinal cord (which will not be discussed in this chapter). Stroke is a term typically used for cerebrovascular events that start abruptly, and it represents a neurological emergency. It can be referred to as “brain attack.” Stroke is a heterogeneous entity and essentially is classified as ischemic and hemorrhagic. Most strokes lead to permanent brain damage and lasting neurological deficits, but over the last few decades, many diagnostic, therapeutic, and process developments have improved significantly its prognosis. Time to restore the blood flow to the affected vessels is of the essence to minimize the brain damage. Of note, CVD also includes the so-called silent strokes which are common and only revealed by advanced neuroimaging techniques. Family medicine physicians need to be closely involved in the primary prevention of strokes and associated CVD, which would have a major impact on the health and welfare of their patients. Also, family medicine practitioners are essential in helping the stroke survivors navigate the rehabilitation process.
Similar content being viewed by others
References
Centers for Disease Control and Prevention/National Center for Health Statistics. https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm
Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–596.
Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, American Heart Association Advocacy Coordinating Committee and Stroke Council, et al. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association [published correction appears in Stroke. 2015;46:e179]. Stroke. 2013;44:2361–75.
World Health Organization. https://www.who.int/gho/mortality_burden_disease/causes_death/top_10/en/
Persky RW, Turtzo LC, McCullough LD. Stroke in women: disparities and outcomes. Curr Cardiol Rep. 2010;12(1):6–13.
Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, et al. The lifetime risk of stroke: estimates from the Framingham study. Stroke. 2006;37:345–50.
Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35–41.
Boehme AK, Esenwa C, Elkind MS. Stroke risk factors, genetics, and prevention. Circ Res. 2017;120(3):472–95. https://doi.org/10.1161/CIRCRESAHA.116.308398.
Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754–832.
Albers GW, Caplan LR, Easton JD, Fayad PB, Mohr JP, Saver JL, et al. Transient ischemic attack–proposal for a new definition. N Engl J Med. 2002;347(21):1713–6.
Easton JD, Saver JL, Albers GW, Alberts MJ, Chaturvedi S, Feldmann E, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke. 2009;40(6):2276–93.
Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284(22):2901–6.
Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370(9596):1432–42.
Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association [published correction appears in Stroke. 2019 Dec;50(12):e440-e441]. Stroke. 2019;50(12):e344–418.
Saver JL. Time is brain – quantified. Stroke. 2006;37(1):263–6.
Ekundayo OJ, Saver JL, Fonarrow GC, Schwamm LH, et al. Patterns of emergency medical services use and its association with timely stroke treatment. Circ Cardiovasc Qual Outcomes. 2013;6:262–9. https://doi.org/10.1161/CIRCOUTCOMES.113.000089Circulation.
American Stroke Association. Available from: http://www.strokeassociation.org/STROKEORG/WarningSigns/Stroke-Warning-Signs-and-Symptoms_UCM_308528_SubHomePage.jsp. Cited 6 June 2020.
AHA/ASA Free NIHSS certification. https://learn.heart.org/lms/nihss. Cited 6 June 2020.
AHA/ASA Target: Stroke https://www.heart.org/en/professional/quality-improvement/target-stroke
Latchaw RE, Alberts MJ, Lev MH, et al. Recommendations for imaging of acute ischemic stroke: a scientific statement from the American Heart Association. Stroke. 2009;40(11):3646–78.
The National Institute of Neurological Disorders and Stroke (NINDS). Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333(24):1581–7.
Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317–29.
Campbell BCV, Mitchell PJ, Churilov L, et al. Tenecteplase versus alteplase before thrombectomy for ischemic stroke. N Engl J Med. 2018;378(17):1573–82.
Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723–31.
Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378(8):708–18.
Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378(1):11–21.
Johnston SC, Easton JD, Farrant M, et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med. 2018;379(3):215–25.
Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369(1):11–9.
Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis [published correction appears in N Engl J Med. 2012;367(1):93]. N Engl J Med. 2011;365(11):993–1003.
Savardekar AR, Narayan V, Patra DP, Spetzler RF, Sun H. Timing of carotid endarterectomy for symptomatic carotid stenosis: a snapshot of current trends and systematic review of literature on changing paradigm towards early surgery. Neurosurgery. 2019;85(2):E214–25.
Qureshi AI, Suarez JI, Yahia AM, Mohammad Y, Uzun G, Suri MF, et al. Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review. Crit Care Med. 2003;31(1):272–7.
Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(7):2160–236.
Sacco S, Marini C, Toni D, Olivieri L, Carolei A. Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke. 2009;40(2):394–9.
Counsell C, Boonyakarnkul S, Dennis M, Sandercock P, Bamford J, Burn J, et al. Primary intracerebral haemorrhage in the Oxfordshire Community Stroke Project, 2: prognosis. Cerebrovasc Dis. 1995;5(1):26–34.
Runchey S, McGee S. Does this patient have a hemorrhagic stroke?: clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;303(22):2280–6.
Hanley DF, Lane K, McBee N, et al. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet. 2017;389(10069):603–11. https://doi.org/10.1016/S0140-6736(16)32410-2.
Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(7):2032–60.
Roquer J, Vivanco Hidalgo RM, Ois A, Rodríguez Campello A, Cuadrado Godia E, Giralt Steinhauer E, et al. Antithrombotic pretreatment increases very-early mortality in primary intracerebral hemorrhage. Neurology. 2017;88(9):885–91.
Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, et al. INTERACT2 Investigators. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med. 2013;368(25):2355–65.
Szaflarski JP, Rackley AY, Kleindorfer DO, Khoury J, Woo D, Miller R, et al. Incidence of seizures in the acute phase of stroke: a population-based study. Epilepsia. 2008;49(6):974–81.
Naidech AM, Garg RK, Liebling S, Levasseur K, Macken MP, Schuele SU, et al. Anticonvulsant use and outcomes after intracerebral hemorrhage. Stroke. 2009;40:3810–5.
Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2012;43(6):1711–37.
Rinkel GJ, Wijdicks EF, Hasan D, Kienstra GE, Franke CL, Hageman LM, et al. Outcome in patients with subarachnoid haemorrhage and negative angiography according to pattern of haemorrhage on computed tomography. Lancet. 1991;338(8773):964–8.
Lall RR, Eddleman CS, Bendok BR, Batjer HH. Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: sifting through the sands of data. Neurosurg Focus. 2009;26(5):E2.
Etminan N, Beseoglu K, Steiger HJ, Hanggi D. The impact of hypertension and nicotine on the size of ruptured intracranial aneurysms. J Neurol Neurosurg Psychiatry. 2011;82(1):4–7.
Shiue I, Arima H, Anderson CS. Life events and risk of subarachnoid hemorrhage: the Australasian cooperative research on subarachnoid hemorrhage study (ACROSS). Stroke. 2010;41(6):1304–6.
Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005;366(9488):809–17.
Hillman J, Fridriksson S, Nilsson O, Yu Z, Saveland H, Jakobsson KE. Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study. J Neurosurg. 2002;97(4):771–8.
Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;3:CD000277.
Lennihan L, Mayer SA, Fink ME, Beckford A, Paik MC, Zhang H, et al. Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage: a randomized controlled trial. Stroke. 2000;31(2):383–91.
Saber H, Desai A, Palla M, Mohamed W, Seraji-Bozorgzad N, Ibrahim M. Efficacy of Cilostazol in prevention of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a meta-analysis. J Stroke Cerebrovasc Dis. 2018;27(11):2979–85.
Naidech AM, Kreiter KT, Janjua N, Ostapkovich N, Parra A, Commichau C, et al. Phenytoin exposure is associated with functional and cognitive disability after subarachnoid hemorrhage. Stroke. 2005;36(3):583–7.
Winstein CJ, Stein J, Arena R, Bates B, Cherney LR, Cramer SC, American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47(6):e98–e169.
Prvu Bettger JA, Kaltenbach L, Reeves MJ, Smith EE, Fonarow GC, Schwamm LH, Peterson ED. Assessing stroke patients for rehabilitation during the acute hospitalization: findings from the get with the guidelines-stroke program. Arch Phys Med Rehabil. 2013;94:38–45. https://doi.org/10.1016/j.apmr.2012.06.029.
McClure JA, Salter K, Foley N, Mahon H, Teasell R. Adherence to Canadian best practice recommendations for stroke care: vascular cognitive impairment screening and assessment practices in an Ontario inpatient stroke rehabilitation facility. Top Stroke Rehabil. 2012;19:141–8. https://doi.org/10.1310/tsr1902-141.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer International Publisher Switzerland
About this entry
Cite this entry
Wagle, K.C., Ivan, C.S. (2020). Cerebrovascular Disease. In: Paulman, P., Taylor, R.B., Paulman, A.A., Nasir, L.S. (eds) Family Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0779-3_72-2
Download citation
DOI: https://doi.org/10.1007/978-1-4939-0779-3_72-2
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-0779-3
Online ISBN: 978-1-4939-0779-3
eBook Packages: Springer Reference MedicineReference Module Medicine
Publish with us
Chapter history
-
Latest
Cerebrovascular Disease- Published:
- 02 November 2020
DOI: https://doi.org/10.1007/978-1-4939-0779-3_72-2
-
Original
Cerebrovascular Disease- Published:
- 16 September 2015
DOI: https://doi.org/10.1007/978-1-4939-0779-3_72-1