Skip to main content

Cerebrovascular Disease

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Family Medicine

Abstract

Cerebrovascular disease (CVD) is a general term encompassing all the brain abnormalities that result from pathologies of its blood vessels (e.g., atherosclerotic, aneurysm, inflammation, dissection). CVD can manifest as an acute onset or chronic condition and can affect any part of the central nervous system, including the spinal cord (which will not be discussed in this chapter). Stroke is a term typically used for cerebrovascular events that start abruptly, and it represents a neurological emergency. It can be referred to as “brain attack.” Stroke is a heterogeneous entity and essentially is classified as ischemic and hemorrhagic. Most strokes lead to permanent brain damage and lasting neurological deficits, but over the last few decades, many diagnostic, therapeutic, and process developments have improved significantly its prognosis. Time to restore the blood flow to the affected vessels is of the essence to minimize the brain damage. Of note, CVD also includes the so-called silent strokes which are common and only revealed by advanced neuroimaging techniques. Family medicine physicians need to be closely involved in the primary prevention of strokes and associated CVD, which would have a major impact on the health and welfare of their patients. Also, family medicine practitioners are essential in helping the stroke survivors navigate the rehabilitation process.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Similar content being viewed by others

References

  1. Centers for Disease Control and Prevention/National Center for Health Statistics. https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm

  2. Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–596.

    Article  PubMed  Google Scholar 

  3. Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, American Heart Association Advocacy Coordinating Committee and Stroke Council, et al. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association [published correction appears in Stroke. 2015;46:e179]. Stroke. 2013;44:2361–75.

    Article  PubMed  Google Scholar 

  4. World Health Organization. https://www.who.int/gho/mortality_burden_disease/causes_death/top_10/en/

  5. Persky RW, Turtzo LC, McCullough LD. Stroke in women: disparities and outcomes. Curr Cardiol Rep. 2010;12(1):6–13.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, et al. The lifetime risk of stroke: estimates from the Framingham study. Stroke. 2006;37:345–50.

    Article  PubMed  Google Scholar 

  7. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35–41.

    Article  PubMed  Google Scholar 

  8. Boehme AK, Esenwa C, Elkind MS. Stroke risk factors, genetics, and prevention. Circ Res. 2017;120(3):472–95. https://doi.org/10.1161/CIRCRESAHA.116.308398.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754–832.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Albers GW, Caplan LR, Easton JD, Fayad PB, Mohr JP, Saver JL, et al. Transient ischemic attack–proposal for a new definition. N Engl J Med. 2002;347(21):1713–6.

    Article  PubMed  Google Scholar 

  11. Easton JD, Saver JL, Albers GW, Alberts MJ, Chaturvedi S, Feldmann E, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke. 2009;40(6):2276–93.

    Article  PubMed  Google Scholar 

  12. Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284(22):2901–6.

    Article  CAS  PubMed  Google Scholar 

  13. Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370(9596):1432–42.

    Article  PubMed  Google Scholar 

  14. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association [published correction appears in Stroke. 2019 Dec;50(12):e440-e441]. Stroke. 2019;50(12):e344–418.

    Article  PubMed  Google Scholar 

  15. Saver JL. Time is brain – quantified. Stroke. 2006;37(1):263–6.

    Article  PubMed  Google Scholar 

  16. Ekundayo OJ, Saver JL, Fonarrow GC, Schwamm LH, et al. Patterns of emergency medical services use and its association with timely stroke treatment. Circ Cardiovasc Qual Outcomes. 2013;6:262–9. https://doi.org/10.1161/CIRCOUTCOMES.113.000089Circulation.

    Article  PubMed  Google Scholar 

  17. American Stroke Association. Available from: http://www.strokeassociation.org/STROKEORG/WarningSigns/Stroke-Warning-Signs-and-Symptoms_UCM_308528_SubHomePage.jsp. Cited 6 June 2020.

  18. AHA/ASA Free NIHSS certification. https://learn.heart.org/lms/nihss. Cited 6 June 2020.

  19. AHA/ASA Target: Stroke https://www.heart.org/en/professional/quality-improvement/target-stroke

  20. Latchaw RE, Alberts MJ, Lev MH, et al. Recommendations for imaging of acute ischemic stroke: a scientific statement from the American Heart Association. Stroke. 2009;40(11):3646–78.

    Article  PubMed  Google Scholar 

  21. The National Institute of Neurological Disorders and Stroke (NINDS). Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333(24):1581–7.

    Article  Google Scholar 

  22. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317–29.

    Article  CAS  PubMed  Google Scholar 

  23. Campbell BCV, Mitchell PJ, Churilov L, et al. Tenecteplase versus alteplase before thrombectomy for ischemic stroke. N Engl J Med. 2018;378(17):1573–82.

    Article  CAS  PubMed  Google Scholar 

  24. Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723–31.

    Article  PubMed  Google Scholar 

  25. Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378(8):708–18.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378(1):11–21.

    Article  PubMed  Google Scholar 

  27. Johnston SC, Easton JD, Farrant M, et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med. 2018;379(3):215–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369(1):11–9.

    Article  CAS  PubMed  Google Scholar 

  29. Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis [published correction appears in N Engl J Med. 2012;367(1):93]. N Engl J Med. 2011;365(11):993–1003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Savardekar AR, Narayan V, Patra DP, Spetzler RF, Sun H. Timing of carotid endarterectomy for symptomatic carotid stenosis: a snapshot of current trends and systematic review of literature on changing paradigm towards early surgery. Neurosurgery. 2019;85(2):E214–25.

    Article  PubMed  Google Scholar 

  31. Qureshi AI, Suarez JI, Yahia AM, Mohammad Y, Uzun G, Suri MF, et al. Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review. Crit Care Med. 2003;31(1):272–7.

    Article  PubMed  Google Scholar 

  32. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(7):2160–236.

    Article  PubMed  Google Scholar 

  33. Sacco S, Marini C, Toni D, Olivieri L, Carolei A. Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke. 2009;40(2):394–9.

    Article  PubMed  Google Scholar 

  34. Counsell C, Boonyakarnkul S, Dennis M, Sandercock P, Bamford J, Burn J, et al. Primary intracerebral haemorrhage in the Oxfordshire Community Stroke Project, 2: prognosis. Cerebrovasc Dis. 1995;5(1):26–34.

    Article  Google Scholar 

  35. Runchey S, McGee S. Does this patient have a hemorrhagic stroke?: clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;303(22):2280–6.

    Article  CAS  PubMed  Google Scholar 

  36. Hanley DF, Lane K, McBee N, et al. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet. 2017;389(10069):603–11. https://doi.org/10.1016/S0140-6736(16)32410-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(7):2032–60.

    Article  PubMed  Google Scholar 

  38. Roquer J, Vivanco Hidalgo RM, Ois A, Rodríguez Campello A, Cuadrado Godia E, Giralt Steinhauer E, et al. Antithrombotic pretreatment increases very-early mortality in primary intracerebral hemorrhage. Neurology. 2017;88(9):885–91.

    Article  CAS  PubMed  Google Scholar 

  39. Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, et al. INTERACT2 Investigators. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med. 2013;368(25):2355–65.

    Article  CAS  PubMed  Google Scholar 

  40. Szaflarski JP, Rackley AY, Kleindorfer DO, Khoury J, Woo D, Miller R, et al. Incidence of seizures in the acute phase of stroke: a population-based study. Epilepsia. 2008;49(6):974–81.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Naidech AM, Garg RK, Liebling S, Levasseur K, Macken MP, Schuele SU, et al. Anticonvulsant use and outcomes after intracerebral hemorrhage. Stroke. 2009;40:3810–5.

    Article  CAS  PubMed  Google Scholar 

  42. Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2012;43(6):1711–37.

    Article  PubMed  Google Scholar 

  43. Rinkel GJ, Wijdicks EF, Hasan D, Kienstra GE, Franke CL, Hageman LM, et al. Outcome in patients with subarachnoid haemorrhage and negative angiography according to pattern of haemorrhage on computed tomography. Lancet. 1991;338(8773):964–8.

    Article  CAS  PubMed  Google Scholar 

  44. Lall RR, Eddleman CS, Bendok BR, Batjer HH. Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: sifting through the sands of data. Neurosurg Focus. 2009;26(5):E2.

    Article  PubMed  Google Scholar 

  45. Etminan N, Beseoglu K, Steiger HJ, Hanggi D. The impact of hypertension and nicotine on the size of ruptured intracranial aneurysms. J Neurol Neurosurg Psychiatry. 2011;82(1):4–7.

    Article  PubMed  Google Scholar 

  46. Shiue I, Arima H, Anderson CS. Life events and risk of subarachnoid hemorrhage: the Australasian cooperative research on subarachnoid hemorrhage study (ACROSS). Stroke. 2010;41(6):1304–6.

    Article  PubMed  Google Scholar 

  47. Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005;366(9488):809–17.

    Article  PubMed  Google Scholar 

  48. Hillman J, Fridriksson S, Nilsson O, Yu Z, Saveland H, Jakobsson KE. Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study. J Neurosurg. 2002;97(4):771–8.

    Article  CAS  PubMed  Google Scholar 

  49. Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;3:CD000277.

    Google Scholar 

  50. Lennihan L, Mayer SA, Fink ME, Beckford A, Paik MC, Zhang H, et al. Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage: a randomized controlled trial. Stroke. 2000;31(2):383–91.

    Article  CAS  PubMed  Google Scholar 

  51. Saber H, Desai A, Palla M, Mohamed W, Seraji-Bozorgzad N, Ibrahim M. Efficacy of Cilostazol in prevention of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a meta-analysis. J Stroke Cerebrovasc Dis. 2018;27(11):2979–85.

    Article  PubMed  Google Scholar 

  52. Naidech AM, Kreiter KT, Janjua N, Ostapkovich N, Parra A, Commichau C, et al. Phenytoin exposure is associated with functional and cognitive disability after subarachnoid hemorrhage. Stroke. 2005;36(3):583–7.

    Article  CAS  PubMed  Google Scholar 

  53. Winstein CJ, Stein J, Arena R, Bates B, Cherney LR, Cramer SC, American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47(6):e98–e169.

    Article  PubMed  Google Scholar 

  54. Prvu Bettger JA, Kaltenbach L, Reeves MJ, Smith EE, Fonarow GC, Schwamm LH, Peterson ED. Assessing stroke patients for rehabilitation during the acute hospitalization: findings from the get with the guidelines-stroke program. Arch Phys Med Rehabil. 2013;94:38–45. https://doi.org/10.1016/j.apmr.2012.06.029.

    Article  PubMed  Google Scholar 

  55. McClure JA, Salter K, Foley N, Mahon H, Teasell R. Adherence to Canadian best practice recommendations for stroke care: vascular cognitive impairment screening and assessment practices in an Ontario inpatient stroke rehabilitation facility. Top Stroke Rehabil. 2012;19:141–8. https://doi.org/10.1310/tsr1902-141.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Kamal C. Wagle or Cristina S. Ivan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer International Publisher Switzerland

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Wagle, K.C., Ivan, C.S. (2020). Cerebrovascular Disease. In: Paulman, P., Taylor, R.B., Paulman, A.A., Nasir, L.S. (eds) Family Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0779-3_72-2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-0779-3_72-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0779-3

  • Online ISBN: 978-1-4939-0779-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Cerebrovascular Disease
    Published:
    02 November 2020

    DOI: https://doi.org/10.1007/978-1-4939-0779-3_72-2

  2. Original

    Cerebrovascular Disease
    Published:
    16 September 2015

    DOI: https://doi.org/10.1007/978-1-4939-0779-3_72-1