Abstract
Respiratory viruses are ubiquitous organisms that can cause a wide spectrum of clinical manifestations in patients of all ages ranging from mild or even asymptomatic upper respiratory tract infections to fatal illnesses with multi-organ failure [1]. Viral infections of the respiratory tract are also common in all age groups and are the leading cause of mortality in children under 5 years of age in developing countries [2]. They pose a significant symptom burden for individuals and a high financial burden to society – mostly due to loss of productivity, healthcare costs, and school absenteeism [3]. Advances in diagnostic testing and improved ability to detect pathogens have demonstrated that viral pathogens are important causal pathogens of respiratory tract infection even in immunocompetent patients. As the number of elderly adults and those with chronic medical conditions increases, the burden of viral respiratory infections has also increased [4].
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References
Heikkinen T. Respiratory viruses and children. J Infect. 2016;72(Suppl):S29–33. https://doi.org/10.1016/j.jinf.2016.04.019.
Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals [published correction appears in Lancet. 2017 May 13;389(10082):1884]. Lancet. 2016;388(10063):3027–35. https://doi.org/10.1016/S0140-6736(16)31593-8.
Kardos P, Malek FA. Common cold – an umbrella term for acute infections of nose, throat, Larynx and Bronchi. Erkältung – ein Sammelbegriff für akute Infektionen von Nase, Rachen, Kehlkopf und Bronchien. Pneumologie. 2017;71(4):221–6. https://doi.org/10.1055/s-0042-116112.
Walter JM, Wunderink RG. Severe respiratory viral infections: new evidence and changing paradigms. Infect Dis Clin N Am. 2017;31(3):455–74. https://doi.org/10.1016/j.idc.2017.05.004.
Weinberg A, Zamora MR. Respiratory viral infections. Preface. Semin Respir Crit Care Med. 2011;32(4):371–2. https://doi.org/10.1055/s-0031-1283277.
Center for Disease Control (CDC). The national respiratory and enteric virus surveillance system (NREVSS). 2020. https://www.cdc.gov/surveillance/nrevss/index.html. Accessed 16 Jun 2020.
Red Book Online. Modes of spread of infectious diseases. 2020. https://redbook.solutions.aap.org/chapter.aspx?sectionId=189639995&bookId=2205&resultClick=1#192295955. Accessed 16 Jun 2020.
Martins Júnior RB, Carney S, Goldemberg D, et al. Detection of respiratory viruses by real-time polymerase chain reaction in outpatients with acute respiratory infection. Mem Inst Oswaldo Cruz. 2014;109(6):716–21. https://doi.org/10.1590/0074-0276140046.
Hodinka RL. Respiratory RNA viruses. Microbiol Spectr. 2016;4(4) https://doi.org/10.1128/microbiolspec.DMIH2-0028-2016.
Kutter JS, Spronken MI, Fraaij PL, Fouchier RA, Herfst S. Transmission routes of respiratory viruses among humans. Curr Opin Virol. 2018;28:142–51. https://doi.org/10.1016/j.coviro.2018.01.001.
Gill PJ, Richardson SE, Ostrow O, Friedman JN. Testing for respiratory viruses in children: to swab or not to swab. JAMA Pediatr. 2017;171(8):798–804. https://doi.org/10.1001/jamapediatrics.2017.0786.
To KK, Lu L, Yip CC, et al. Additional molecular testing of saliva specimens improves the detection of respiratory viruses. Emerg Microbes Infect. 2017;6(6):e49. https://doi.org/10.1038/emi.2017.35. Published 7 Jun 2017.
Heikkinen T, Järvinen A. The common cold. Lancet. 2003;361(9351):51–9. https://doi.org/10.1016/S0140-6736(03)12162-9.
Arroll B. Common cold. BMJ Clin Evid. 2011;2011:1510. Published 16 Mar 2011.
DeGeorge KC, Ring DJ, Dalrymple SN. Treatment of the common cold. Am Fam Physician. 2019;100(5):281–9.
Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;6:CD000247.
Spurling GK, Del Mar CB, Dooley L, et al. Delayed antibiotic prescriptions for respiratory infections. Cochrane Database Syst Rev. 2017;9:CD004417.
U.S. Food Drug Administration. Use caution when giving cough and cold products to kids. 2020. https://www.fda.gov/drugs/special-features/use-caution-when-giving-cough-and-cold-products-kids. Accessed 23 June 2020.
Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014;2014(11):CD001831. https://doi.org/10.1002/14651858.CD001831.pub5. Published 24 Nov 2014.
Dworkin JP. Laryngitis: types, causes, and treatments. Otolaryngol Clin N Am. 2008;41(2):419–ix. https://doi.org/10.1016/j.otc.2007.11.011.
Reveiz L, Cardona AF. Antibiotics for acute laryngitis in adults. Cochrane Database Syst Rev. 2015;2015(5):CD004783. https://doi.org/10.1002/14651858.CD004783.pub5. Published 23 May 2015
Stachler RJ, Francis DO, Schwartz SR, et al. Clinical practice guideline: hoarseness (dysphonia) (update) [published correction appears in Otolaryngol Head Neck Surg. 2018 Aug;159(2):403]. Otolaryngol Head Neck Surg. 2018;158(Suppl 1):S1–S42. https://doi.org/10.1177/0194599817751030.
Centers for Disease Control (CDC). Types of influenza viruses. 2020. http://www.cdc.gov/flu/about/viruses/types.htm. Accessed 30 Jun 2020.
Iuliano AD, Roguski KM, Chang HH, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study [published correction appears in Lancet. 2018 Jan 19]. Lancet. 2018;391(10127):1285–300. https://doi.org/10.1016/S0140-6736(17)33293-2.
Center for Disease Control (CDC). The Flu season. 2020. https://www.cdc.gov/flu/about/season/flu-season.htm. Accessed 30 Jun 2020.
WHO. WHO guidelines for pharmacological management of pandemic influenza A(H1N1) 2009 and other influenza viruses. Geneva: World Health Organization; 2010.
Centers for Disease Control (CDC). Clinical signs and symptoms of influenza. 2020. https://www.cdc.gov/flu/professionals/acip/clinical.htm. Accessed 30 Jun 2020.
Centers for Disease Control (CDC). Influenza antiviral medications: summary for clinicians. 2020. https://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm. Accessed 30 Jun 2020.
Centers for Disease Control (CDC). Influenza vaccination: a summary for clinicians. 2020. https://www.cdc.gov/flu/professionals/vaccination/vax-summary.htm. Accessed 30 Jun 2020.
Demicheli V, Jefferson T, Ferroni E, Rivetti A, Di Pietrantonj C. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev. 2018;2(2):CD001269. https://doi.org/10.1002/14651858.CD001269.pub6. Published 1 Feb 2018.
Harris AM, Hicks LA, Qaseem A, High Value Care Task Force of the American College of Physicians and for the Centers for Disease Control and Prevention. Appropriate antibiotic use for acute respiratory tract infection in adults: advice for High-Value Care from the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2016;164(6):425–34. https://doi.org/10.7326/M15-1840.
Ebell MH, Lundgren J, Youngpairoj S. How long does a cough last? Comparing patients’ expectations with data from a systematic review of the literature. Ann Fam Med. 2013;11(1):5–13. https://doi.org/10.1370/afm.1430.
Altiner A, Wilm S, Däubener W, et al. Sputum colour for diagnosis of a bacterial infection in patients with acute cough. Scand J Prim Health Care. 2009;27(2):70–3. https://doi.org/10.1080/02813430902759663.
Smith SM, Fahey T, Smucny J, Becker LA. Antibiotics for acute bronchitis. Cochrane Database Syst Rev. 2017;6(6):CD000245. https://doi.org/10.1002/14651858.CD000245.pub4. Published 19 Jun 2017.
Becker LA, Hom J, Villasis-Keever M, van der Wouden JC. Beta2-agonists for acute cough or a clinical diagnosis of acute bronchitis. Cochrane Database Syst Rev. 2015;2015(9):CD001726. https://doi.org/10.1002/14651858.CD001726.pub5. Published 3 Sept 2015
COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). 2020. https://coronavirus.jhu.edu/map.html. Accessed on 30 Jun 2020.
Gandhi RT, Lynch JB, Del Rio C. Mild or moderate Covid-19 [published online ahead of print, 2020 Apr 24]. N Engl J Med. 2020; https://doi.org/10.1056/NEJMcp2009249.
Berlin DA, Gulick RM, Martinez FJ. Severe Covid-19 [published online ahead of print, 2020 May 15]. N Engl J Med. 2020; https://doi.org/10.1056/NEJMcp2009575.
Bradley BT, Bryan A. Emerging respiratory infections: the infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella. Semin Diagn Pathol. 2019;36(3):152–9. https://doi.org/10.1053/j.semdp.2019.04.006.
Centers for Disease Control (CDC). Respiratory hygiene/cough Etiquette in healthcare settings. 2020. https://www.cdc.gov/flu/professionals/infectioncontrol/resphygiene.htm. Accessed 30 Jun 2020.
Centers for Disease Control (CDC). Considerations for wearing cloth face coverings. 2020. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/cloth-face-cover-guidance.html. Accessed 30 Jun 2020.
Centers for Disease Control (CDC). Biggest threats and data. 2020. https://www.cdc.gov/drugresistance/biggest-threats.html. Accessed 30 Jun 2020.
McDonagh MS, Peterson K, Winthrop K, Cantor A, Lazur BH, Buckley DI. Interventions to reduce inappropriate prescribing of antibiotics for acute respiratory tract infections: summary and update of a systematic review. J Int Med Res. 2018;46(8):3337–57. https://doi.org/10.1177/0300060518782519.
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Coghill, L., Gitu, A. (2020). Viral Infections of the Respiratory Tract. In: Paulman, P., Taylor, R.B., Paulman, A.A., Nasir, L.S. (eds) Family Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0779-3_169-1
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DOI: https://doi.org/10.1007/978-1-4939-0779-3_169-1
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