Abstract
Advances in functional imaging techniques including fMRI, PET, and SPECT have improved our understanding of the relationship between brain activity and brain energy supply. Neurovascular and neurometabolic coupling are critical to supply the energy demands of brain tissue during both normal physiological function and pathological conditions. With the use of multi-spectral imaging techniques, one can simultaneously measure changes in cerebral blood volume, oxyhemoglobin, deoxyhemoglobin, light scattering, and local metabolism during epilepsy.
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Acknowledgements
This work was supported by the NINDS RO1 NS49482 (T.H.S), CURE Taking Flight Award (H.M.), the Clinical and Translational Science Center (CTSC) Grant UL1 RR 024996 Pilot Grant (M.Z), and the Cornell University Ithaca-WCMC seed grant (M.Z.). We thank Dr. Yevgeniy B. Sirotin for help with LED setup and AFI analysis.
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Zhao, M., Ma, H., Harris, S., Schwartz, T.H. (2014). Multi-Spectral Imaging of Blood Volume, Metabolism, Oximetry, and Light Scattering. In: Zhao, M., Ma, H., Schwartz, T. (eds) Neurovascular Coupling Methods. Neuromethods, vol 88. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0724-3_10
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DOI: https://doi.org/10.1007/978-1-4939-0724-3_10
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