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Dendritic Cells

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Cancer Therapeutic Targets

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Abstract

In 1868, Paul Langerhans discovered the first immune cell during a study of the skin. The cells he discovered, dendritic cells (DCs), were named for their long projections that made them resemble the dendrites of nerve cells, which was the function Langerhans assigned to them at that time. The true role of DCs as powerful antigen-presenting cells (APC) was elucidated by Ralph Steinman in 1973, in studies that ultimately led to the award of a Nobel Prize in 2011. These cells play a vital role in our immune system, covering both innate and adaptive immune responses, and come from a variety of lineages and have various locations (Kuby et al. 2007).

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA

    Hannah E. Goyne

  2. Microbiology & Immunology, University of Arkansas, 4301 W. Markham St., Little Rock, AR, 72205, USA

    Martin Cannon

Authors
  1. Hannah E. Goyne
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  2. Martin Cannon
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Correspondence to Hannah E. Goyne .

Editor information

Editors and Affiliations

  1. Georgetown University Div. Hematology & Oncology, Washington, District of Columbia, USA

    John L. Marshall

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© 2013 Springer Science+Business Media New York

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Goyne, H.E., Cannon, M. (2013). Dendritic Cells. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6613-0_62-4

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  • DOI: https://doi.org/10.1007/978-1-4614-6613-0_62-4

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6613-0

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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