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The Sense of Smell: Role of the Olfactory System in Social Behavior

Neuroscience in the 21st Century

Abstract

Olfaction is the sense of smell, which is mediated by specialized sensory neurons in the nasal cavity. Classically, the olfactory system is divided into two anatomically independent olfactory systems, the main olfactory system and the accessory olfactory system. Evidence from rodents indicates the presence of other spatially segregated subpopulations of sensory neurons within the mammalian nose. These subpopulations project to different brain areas and process chemosensory information ranging from location of prey and predators, the sexual, hormonal, and reproductive as well as health state of (mating) partners, and care of offspring to the level of aggression in rivals. These subpopulations of sensory neurons use different signaling cascades for the transduction of information from chemosensory molecules into electrical membrane signals. Considerable progress has been achieved in the comprehension of how various olfactory cues are detected and can influence social behavior. But, in many cases questions remain regarding the mechanisms in the brain by which olfactory stimuli influence physiology and behavior in specific brain regions and regarding the individual neuronal circuits and neurons that mediate these effects. The current knowledge on the behavioral, physiological, and molecular aspects of odor detection in mammals including humans is presented in this chapter.

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References

  • Becker JB, Breedlove SM, Crews D, McCarthy MM (2002) Behavioral endocrinology, 2nd edn. Massachusetts Institute of Technology, Cambridge, MA

    Google Scholar 

  • Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175–187

    Article  CAS  Google Scholar 

  • Firestein S (2001) How the olfactory system makes sense of scents. Nature 413:211–218

    Article  CAS  Google Scholar 

  • Jennings KJ, de Lecea L (2020) Neural and hormonal control of sexual behavior. Endocrinology 161:1–13

    Article  Google Scholar 

  • Liberles SD (2014) Review examining the chemical diversity of pheromones, their detection and processing by the various olfactory subsystems and neural circuits, as well as the generation of particular behavioral and endocrine responses. Mammalian pheromones. Annu Rev Physiol 76:151–175

    Article  CAS  Google Scholar 

  • Meredith M (2001) Human vomeronasal organ function: a critical review of best and worst cases. Chem Senses 26:433–445

    Article  CAS  Google Scholar 

  • Munger SD, Leinders-Zufall T, McDougall LM, Cockerham RE, Schmid A, Wandernoth P, Wennemuth G, Biel M, Zufall F, Kelliher KR (2010) An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol 20:1438–1444

    Article  CAS  Google Scholar 

  • Perez-Gomez A, Bleymehl K, Stein B, Pyrski M, Birnbaumer L, Munger SD, Leinders-Zufall T, Zufall F, Chamero P (2015) Innate predator odor aversion driven by parallel olfactory subsystems that converge in the ventromedial hypothalamus. Curr Biol 25:1340–1346

    Article  CAS  Google Scholar 

  • Sanchez-Andrade G, Logan DW (2014) Deconstructing pheromone-mediated behavior one layer at a time. BMC Biol 12:33–35

    Article  Google Scholar 

  • Shepherd GM (2013) Neurogastronomy: how the brain creates flavor and why it matters. Columbia University Press, New York

    Book  Google Scholar 

  • Tirindelli R, Dibattista M, Pifferi S, Menini A (2009) From pheromones to behavior. Physiol Rev 89:921–956

    Article  CAS  Google Scholar 

  • Wyatt TD (2014) Pheromones and animal behaviour: chemical signals and signatures, 2nd edn. Cambridge University Press, Cambridge. This book provides a comprehensive overview of the field of chemical communication and how chemosignals shape social interactions. ISBN 9780521130196

    Google Scholar 

  • Wyatt TD (2015) The search for human pheromones: the lost decades and the necessity of returning to first principles. Proc Biol Sci 282. https://doi.org/10.1098/rspb.2014.2994

  • Wysocki CJ, Preti G (2004) Facts, fallacies, fears, and frustrations with human pheromones. Anat Rec A Discov Mol Cell Evol Biol 281:1201–1211. This review takes a critical look on the role of pheromones in human interactions

    Article  Google Scholar 

  • Zufall F, Munger SD (2016) Chemosensory transduction: the detection of odors, tastes and other chemostimuli, 1st edn. Academic, Amsterdam

    Google Scholar 

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Correspondence to Julie Bakker .

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Bakker, J., Leinders-Zufall, T., Chamero, P. (2021). The Sense of Smell: Role of the Olfactory System in Social Behavior. In: Pfaff, D.W., Volkow, N.D., Rubenstein, J. (eds) Neuroscience in the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6434-1_29-4

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  • DOI: https://doi.org/10.1007/978-1-4614-6434-1_29-4

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6434-1

  • Online ISBN: 978-1-4614-6434-1

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Chapter history

  1. Latest

    The Sense of Smell: Role of the Olfactory System in Social Behavior
    Published:
    11 May 2022

    DOI: https://doi.org/10.1007/978-1-4614-6434-1_29-4

  2. Original

    The Sense of Smell: Role of the Olfactory Systems in Detecting Pheromones
    Published:
    17 December 2015

    DOI: https://doi.org/10.1007/978-1-4614-6434-1_29-3