Abstract
Whole organ pancreas transplantation is increasingly being performed for the treatment of diabetes mellitus. To date, over 32,000 pancreas transplants have been performed worldwide. The procedure is associated with significant mortality and morbidity in early transplant period. However, the successful pancreas transplantation has the potential to render patients insulin-independent and halt the progression of complications of diabetes, thereby improving both quality of life and patient survival.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Kelly WD, Lillehei RC, Merkel FK et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 1967; 61(6):827–837.
Perosa M, Boggi U, Cantarovich D et al. Pancreas transplantation outside the USA: An update. Cuit Opin Organ Transplant 2011.
Reddy KS, Stablein D, Taranto S et al. Long-term survival following simultaneous kidney-pancreas transplantation versus kidney transplantation alone in patients with type 1 diabetes mellitus and renal failure. Am J Kidney Dis 2003; 41(2):464–470.
Sollinger HW, Odorico JS, Becker YT et al. One thousand simultaneous pancreas-kidney transplants at a single center with 22-year follow-up. Arm Surg 2009; 250(4):618–30
Morath C, Zeier M, Dohler B et al. Transplantation of the type 1 diabetic patient: The long-term benefit of a functioning pancreas allograft. Clin J Am Soc Nephrol 2010; 5(3):549–552.
Navarro X, Sutherland DE, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 1997; 42(5):727–736.
Giannarelli R, Coppelli A, Sartini MS et al. Pancreas transplant alone has beneficial effects on retinopathy in type 1 diabetic patients. Diabetologia 2006; 49(12):2977–2982.
Fioretto P, Steffes MW, Sutherland DE et al. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 1998; 339(2):69–75.
White SA, Shaw JA, Sutherland DE. Pancreas transplantation. Lancet 2009; 373(9677):1808–1817.
Kaufman DB. Pancreas transplantation clinical presentation. Medscape Reference [serial on internet). 2011 March 16. Available from http://emedicine.emdscape.com/article/429408-clinical.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). National diabetes statistics, 2011. Bethesda: National Institutes of Health; 2011 February. Available from http://diabetes.niddk.nih.gov/dm/pubs/statistics/2011.
Nghiom DD, Cony RJ. Technique of simultaneous renal pancreatoduodenal transplantation with urinary drainage of pancreatic secretion. Am J Surg 1987; 153(4):405–406.
West M, Gruessner AC, Metrakos P et al. Conversion from bladderto enteric drainage after pancreaticoduodenal transplantations. Surgery 1998; 124(5):883–893.
Monroy-Cuadros M, Salazar A, Yilmaz S et al. Bladder vs enteric drainage in simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant 2006; 21(2):483–487.
Jimenez-Romero C, Manrique A, Morales JM et al. Conversion from bladder to enteric drainage for complications after pancreas transplantation. Transplant Proc 2009; 41(6):2469–2471.
Gruessner AC, Sutherland DE. Pancreas transplant outcomes for united states (US) and non-US cases as reported to the united network for organ sharing (UNOS) and the international pancreas transplant registry (IPTR) as of june 2004. Clin Transplant 2005; 19(4):433–455.
Vaidya A, Muthusamy AS, Hadjianastassiou VG et al. Simultaneous pancreas—kidney transplantation: To anticoagulate or not? is that a question? Clin Transplant 2007; 21(4):554–557.
Larson TS, Bohorquez II, Rea DJ et al. Pancreas-after-kidney transplantation: An increasingly attractive alternative to simultaneous pancreas-kidney transplantation. Transplantation 2004; 77(6):838–843.
Dobos N, Roberts DA, Insko EK et al. Contrast-enhanced MR angiography for evaluation of vascular complications of the pancreatic transplant. Radiographies 2005; 25(3):687–695.
Ricart MJ, Malaise J, Moreno A et al. Cytomegalovirus: Occurrence, severity, and effect on graft survival in simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant 2005; 20(Suppl 2):ii25–32, ii62.
Goodman J, Becker YT. Pancreas surgical complications. Curr Opin Organ Transplant 2009; 14(l):85–89.
Troppmann C, Gruessner AC, Benedetti E et al. Vascular graft thrombosis after pancreatic transplantation: Univariate and multivariate operative and non-operative risk factor analysis. J Am Coll Surg 1996; 182(4):285–316.
Gilabert R, Femandez-Cruz L, Real MI et al. Treatment and outcome of pancreatic venous graft thrombosis after kidney—pancreas transplantation. Br J Surg 2002; 89(3):355–360.
Hagspiel KD, Nandalur K, Pruett TL et al. Evaluation of vascular complications of pancreas transplantation with high-spatial-resolution contrast-enhanced MR angiography. Radiology 2007; 242(2): 590–599.
Eubank WB, Schmiedl UP, Levy AE et al. Venous thrombosis and occlusion after pancreas transplantation: Evaluation with breath-hold gadolinium-enhanced three-dimensional MR imaging. AJR Am J Roentgenol 2000; 175(2):381–385.
Barone GW, Webb JW, Hudec WA. The enteric drained pancreas transplant: Another potential source of gastrointestinal bleeding. Am J Gastroenterol 1998; 93(8): 1369–1371.
Bingener-Casey J, Esterl RM Jr, Kenneth Washburn W et al. Tc-99m-labeled red blood cell scanning localizes anastomotic hemorrhage between the distal ileum and duodenal stump of an enteric-drained pancreas transplant. Clin Nucl Med 2002; 27(3):205–206.
Green BT, Tuttle-Newhall J, Suhocki P et al. Massive gastrointestinal hemorrhage due to rupture of a donor pancreatic artery pseudoaneurysm in a pancreas transplant patient. Clin Transplant 2004; 18(1): 108–111.
Verni MP, Leone JP, DeRoover A. Pseudoaneurysm of the Y-graft/iliac artery anastomosis following pancreas transplantation: A case report and review of the literature. Clin Transplant 2001; 15(l):72–76.
Tzakis AG, Carroll PB, Gordon RD et al. Arterial mycotic aneurysm and rapture. A potentially fatal complication of pancreas transplantation in diabetes mellitus. Arch Surg 1989; 124(6):660–661.
Dalla Valle R, Capocasale E, Mazzoni MP et al. Embolization of a ruptured pseudoaneurysm with massive hemorrhage following pancreas transplantation: A case report. Transplant Proc 2005; 37(5):2275–2277.
Patel BK, Garvin PJ, Aridge DL et al. Fluid collections developing after pancreatic transplantation: Radiologic evaluation and intervention. Radiology 1991; 181(l):215–220.
Lall CG, Sandrasegaran K, Maglinte DT et al. Bowel complications seen on CT afterpancreas transplantation with enteric drainage. AJR Am J Roentgenol 2006; 187(5):1288–1295.
Kapoor A. Malignancy in kidney transplant recipients. Drugs 2008; 68Suppl 1:11–19.
Gutierrez-Dalmau A, Campistol JM. Immunosuppressive therapy and malignancy in organ transplant recipients: A systematic review. Drags 2007; 67(8):1167–1198.
Issa N, Amer H, Dean PG et al. Posttransplantlymphoproliferative disorder following pancreas transplantation. Am J Transplant 2009; 9(8):1894–1902.
Meador TL, Krebs TL, Cheong JJ et al. Imaging features of posttransplantation lymphoproliferative disorder in pancreas transplant recipients. AJR Am J Roentgenol 2000; 174(1): 121–124.
Pickhardt PJ, Siegel MJ. Posttransplantation lymphoproliferative disorder of the abdomen: CT evaluation in 51 patients. Radiology 1999; 213(1):73–78.
Collaborative Islet Transplant Registry (CITR). Collaborative islet transplant registry (CITR) 2009 report. www.citregistry.org. Accessed, 2011.
The US Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients COPTN/SRTR. Annual report: transplant data 1999–2008. http://optn.transplant.hrsa.gov/ar2009/III_AR_CD.htm?cp=4#2. Accessed, 2011.
Ryan EA, Paty BW, Senior PA et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54(7):2060–2069.
Shapiro AM, Ricordi C, Hering BJ et al. International trial of the edmonton protocol for islet transplantation. N Engl J Med 2006; 355(13): 1318–1330.
Ryan EA, Lakey JR, Paty BW et al. Successful islet transplantation: Continued insulin reserve provides long-term glycemic control. Diabetes 2002; 51(7):2148–2157.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Landes Bioscience and Springer Science+Business Media
About this chapter
Cite this chapter
Tavakoli, A., Liong, S. (2013). Pancreatic Transplant in Diabetes. In: Ahmad, S.I. (eds) Diabetes. Advances in Experimental Medicine and Biology, vol 771. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5441-0_30
Download citation
DOI: https://doi.org/10.1007/978-1-4614-5441-0_30
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-5440-3
Online ISBN: 978-1-4614-5441-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)