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Drugs and ECMO

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Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

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Abstract

Children and adults supported by extracorporeal membrane oxygenation (ECMO) are critically ill with substantial alterations in end-organ function and vasomotor tone prior to and during ECMO support. Although ECMO circuit components, technology, and our knowledge of ECMO patient and circuit management have improved in recent years, medication delivery, optimal dosing, and drug pharmacokinetics remain a significant concern when managing ECMO patients.

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Abbreviations

AKI:

Acute kidney injury

BP:

Blood pressure

CI:

Clearance

CRRT:

Continuous renal replacement therapy

MIC:

Minimum inhibitory concentration

PD:

Pharmacodynamics

PK:

Pharmacodynamics

PMP:

Polymethylpentene

PP:

Polypropylene

PVC:

Polyvinylchloride

TDM:

Therapeutic drug monitoring

TTM:

Targeted temperature management

SVR:

Systemic vascular resistance

VA:

Veno-arterial

Vd:

Volume of distribution

VV:

Veno-venous

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Author information

Authors and Affiliations

  1. Sacred Heart Medical Center & Children’s Hospital, Spokane, WA, USA

    Jennifer Eshelman

  2. Division of Cardiac Critical Care, Harvard Medical School, Boston, MA, USA

    Ravi Thiagarajan

  3. Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA

    Richard J. Ing

  4. Division of Pediatric Cardiology, Department of Pediatrics, Childrens Hospital of Colorado, University of Colorado School of Medicine, Aurora, CO, USA

    Cindy S. Barrett

Authors
  1. Jennifer Eshelman
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  2. Ravi Thiagarajan
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  3. Richard J. Ing
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  4. Cindy S. Barrett
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Corresponding author

Correspondence to Cindy S. Barrett .

Editor information

Editors and Affiliations

  1. Children’s Hospital Colorado University of Colorado Denver, School of, Aurora, CO, USA

    Eduardo M. da Cruz

  2. Children's Hospital Colorado University of Colorado School of Medicin, Aurora, CO, USA

    Dunbar Ivy

  3. Department of Cardiac Surgery, German Pediatric Heart Center, Sankt Augustin, Germany

    Viktor Hraska

  4. Pediatric Cardiac Surgery, Children's Hospital Colorado University of Colorado, Aurora, CO, USA

    James Jaggers

Section Editor information

  1. Pediatrics and Heart and Vascular Institute, Inova Fairfax Medical Center, Falls Church, Virginia, USA

    Heidi J. Dalton

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Eshelman, J., Thiagarajan, R., Ing, R.J., Barrett, C.S. (2020). Drugs and ECMO. In: da Cruz, E., Ivy, D., Hraska, V., Jaggers, J. (eds) Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer, London. https://doi.org/10.1007/978-1-4471-4999-6_179-2

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  • DOI: https://doi.org/10.1007/978-1-4471-4999-6_179-2

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