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Methods for the Production of Radiolabeled Bioagents for ImmunoPET

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Positron Emission Tomography

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2729))

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Abstract

Immunoglobulin-based positron emission tomography (ImmunoPET) is making increasingly significant contributions to the nuclear imaging toolbox. The exquisite specificity of antibodies combined with the high-resolution imaging of PET enables clinicians and researchers to localize diseases, especially cancer, with a high degree of spatial certainty. This review focuses on the radiopharmaceutical preparation necessary to obtain those images—the work behind the scenes, which occurs even before the patient or animal is injected with the radioimmunoconjugate. The focus of this methods review will be the chelation of four radioisotopes to their most common and clinically relevant chelators.

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Acknowledgments

We gratefully acknowledge the Radiochemistry and Molecular Imaging Probes Core (RMIP Core) at MSK, which is supported by NIH grant P30 CA08748. This work was also supported by NIH NCI R35 CA232130 (JSL).

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Authors and Affiliations

  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Alejandro Arroyo, Serge K. Lyashchenko & Jason S. Lewis

  2. Radiochemistry and Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Serge K. Lyashchenko & Jason S. Lewis

  3. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jason S. Lewis

Authors
  1. Alejandro Arroyo
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  2. Serge K. Lyashchenko
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  3. Jason S. Lewis
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Corresponding author

Correspondence to Jason S. Lewis .

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Editors and Affiliations

  1. School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK

    Timothy H. Witney

  2. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada

    Adam J. Shuhendler

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Arroyo, A., Lyashchenko, S.K., Lewis, J.S. (2024). Methods for the Production of Radiolabeled Bioagents for ImmunoPET. In: Witney, T.H., Shuhendler, A.J. (eds) Positron Emission Tomography. Methods in Molecular Biology, vol 2729. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3499-8_8

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  • DOI: https://doi.org/10.1007/978-1-0716-3499-8_8

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3498-1

  • Online ISBN: 978-1-0716-3499-8

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