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Preparation of [68Ga]GaCl3 Using a Cyclotron

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Positron Emission Tomography

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2729))

Abstract

Recent developments in 68Ga-radiopharmaceuticals, including a number of regulatory approvals for clinical use, has created a hitherto unprecedented demand for 68Ga. Reliable access to enough 68Ga to meet growing clinical demand using only 68Ge/68Ga generators has been problematic in recent years. To address this challenge, we have optimized the direct production of 68Ga on a cyclotron via the 68Zn(p,n)68Ga reaction using a liquid target. This protocol describes the cyclotron-based production of [68Ga]GaCl3 implemented at the University of Michigan using a liquid target on GE PETtrace instrumentation. The protocol provides 56 ± 4 mCi (n = 3) of [68Ga]GaCl3 that meets the necessary quality control criteria to use for the preparation of 68Ga-radiopharmaceuticals for human use.

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Author information

Authors and Affiliations

  1. Department of Radiology, University of Michigan, Ann Arbor, MI, USA

    Melissa E. Rodnick & Peter J. H. Scott

  2. GE Healthcare, GEMS PET Systems, Uppsala, Sweden

    Carina Sollert, D. Christian Parr, Jens Frigell & Katherine Gagnon

Authors
  1. Melissa E. Rodnick
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  2. Carina Sollert
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  3. D. Christian Parr
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  4. Jens Frigell
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  5. Katherine Gagnon
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  6. Peter J. H. Scott
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Corresponding author

Correspondence to Katherine Gagnon .

Editor information

Editors and Affiliations

  1. School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK

    Timothy H. Witney

  2. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada

    Adam J. Shuhendler

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Rodnick, M.E., Sollert, C., Parr, D.C., Frigell, J., Gagnon, K., Scott, P.J.H. (2024). Preparation of [68Ga]GaCl3 Using a Cyclotron. In: Witney, T.H., Shuhendler, A.J. (eds) Positron Emission Tomography. Methods in Molecular Biology, vol 2729. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3499-8_5

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  • DOI: https://doi.org/10.1007/978-1-0716-3499-8_5

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3498-1

  • Online ISBN: 978-1-0716-3499-8

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