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PET System Technology: Theoretical Aspects and Experimental Methodology

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Positron Emission Tomography

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2729))

Abstract

Positron emission tomography (PET) imaging provides unique information of the cellular and molecular pathways of disease occurring within the human body, using measurements made from outside the body, which has shown utility in a variety of studies from basic research to clinical applications. This chapter describes some of the most relevant PET system parameters that impact its imaging performance such as 3D spatial, energy, and coincidence timing resolutions and the methodology typically used to evaluate those parameters. In addition, the physical principles underlying PET imaging, PET photon detector technology, and coincidence detection are also described. As a closing remark, the future perspectives of PET imaging and its simultaneous use with anatomical imaging techniques (e.g., computed tomography [CT] and magnetic resonance imaging [MRI]) are outlined.

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Acknowledgments

This work was partially supported by NIH grants R01CA214669 and R01EB025125 and by the VALi+d Program for Researchers in Postdoctoral Phase of the Ministry of Labor and Social Economy (Generalitat de Valencia) and the European Social Fund.

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Authors and Affiliations

  1. Department of Radiology, Stanford University, Stanford, CA, USA

    Andrea Gonzalez-Montoro & Craig S. Levin

  2. Departments of Radiology, Bioengineering, Physics, and Electrical Engineering, Stanford University, Stanford, CA, USA

    Craig S. Levin

Authors
  1. Andrea Gonzalez-Montoro
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  2. Craig S. Levin
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Corresponding author

Correspondence to Craig S. Levin .

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Editors and Affiliations

  1. School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK

    Timothy H. Witney

  2. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada

    Adam J. Shuhendler

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Gonzalez-Montoro, A., Levin, C.S. (2024). PET System Technology: Theoretical Aspects and Experimental Methodology. In: Witney, T.H., Shuhendler, A.J. (eds) Positron Emission Tomography. Methods in Molecular Biology, vol 2729. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3499-8_20

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  • DOI: https://doi.org/10.1007/978-1-0716-3499-8_20

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3498-1

  • Online ISBN: 978-1-0716-3499-8

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