Abstract
The Nipah and Hendra viruses, belonging to henipavirus genus, are recently emerged zoonotic pathogens that cause severe and often fatal, neurologic, and/or respiratory diseases in both humans and various animals. As mice represent a small animal model convenient to study viral infections and provide a well-developed experimental toolbox for analysis in immunovirology, we describe in this chapter a few basic methods used in biosafety 4 level (BSL4) conditions to study henipavirus infection in mice.
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Acknowledgement
The authors acknowledge the contribution of all the members of INSERM Laboratory P4 Jean Mérieux, particularly Audrey Vallve, and Immunobiology of viral infection team at CIRI for the realization of the manuscript. The work was supported by INSERM, LABEX ECOFECT (ANR-11-LABX-0048) of Lyon University, within the program “Investissements d’Avenir” (ANR-11-IDEX-0007) and Aviesan Nipah virus study project.
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Iampietro, M., Barron, S., Duthey, A., Horvat, B. (2023). Mouse Models of Henipavirus Infection. In: Freiberg, A.N., Rockx, B. (eds) Nipah Virus. Methods in Molecular Biology, vol 2682. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3283-3_10
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DOI: https://doi.org/10.1007/978-1-0716-3283-3_10
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