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Details in Conducting Human Laboratory Alcohol Administration and Self-Administration Experiments to Assess Subjective Response and Craving for Alcohol

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Translational Research Methods for Alcohol Use Disorders

Part of the book series: Neuromethods ((NM,volume 201))

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Abstract

Human laboratory methods are valuable approaches to studying the etiology of alcohol misuse and interventions to ameliorate misuse because they offer advantages such as enhanced experimental control and relative efficiency compared to other methods. Yet, published reports from laboratory alcohol administration experiments typically do not provide a sufficient degree of detail for readers to replicate these procedures themselves. The primary goal of this chapter is to provide fine-grained details on experimental laboratory methods to assess subjective response and craving for alcohol: two mechanisms underlying alcohol misuse that we have learned the most about using laboratory alcohol administration paradigms. The detailed steps described here relied heavily on one research group’s approach with several alternatives offered. We describe the materials needed to conduct laboratory alcohol administration research followed by a step-by-step description of the methods involved in chronological order, beginning with day before procedures to prepare for a laboratory session; day of procedures, including calculating fixed doses of alcohol to target particular breath alcohol levels, pre-session baseline, beverage administration procedures; and day-after procedures. We conclude this chapter by discussing several key decisions investigators must make when designing a laboratory alcohol administration study. While there are several validated and reliable methods for conducting experimental laboratory research, investigators interested in subjective response and alcohol craving must carefully consider how their research questions and approaches align, while also taking into account the many potential logistical limitations.

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References

  1. Cyders MA, Plawecki MH, Corbin W, King A, McCarthy DM, Ramchandani VA, Weafer J, O’Connor SJ (2020) To infuse or ingest in human laboratory alcohol research. Alcohol Clin Exp Res 44(4):764–776. https://doi.org/10.1111/acer.14305

    Article  PubMed  PubMed Central  Google Scholar 

  2. Halsall L, Jones A, Roberts C, Knibb G, Rose AK (2022) The impact of alcohol priming on craving and motivation to drink: a meta analysis. Addiction 117:2986–3003. https://doi.org/10.1111/add.15962

    Article  PubMed  PubMed Central  Google Scholar 

  3. Schuckit MA (1984) Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 41(9):879. https://doi.org/10.1001/archpsyc.1984.01790200061008

    Article  CAS  PubMed  Google Scholar 

  4. Plebani JG, Ray LA, Morean ME, Corbin WR, MacKillop J, Amlung M, King AC (2012) Human laboratory paradigms in alcohol research. Alcohol Clin Exp Res 36(6):455–466. https://doi.org/10.1111/j.1530-0277.2011.01704.x

    Article  Google Scholar 

  5. Ray LA, Green R, Roche DJ, Magill M, Bujarski S (2019) Naltrexone effects on subjective responses to alcohol in the human laboratory: a systematic review and meta-analysis. Addict Biol 24(6):1138–1152. https://doi.org/10.1111/adb.12747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yardley MM, Ray LA (2017) Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models. Addict Biol 22(3):581–615. https://doi.org/10.1111/adb.12349

    Article  PubMed  Google Scholar 

  7. Bujarski S, Hutchison KE, Roche DJO, Ray LA (2015) Factor structure of subjective responses to alcohol in light and heavy drinkers. Alcohol Clin Exp Res 39(7):1193–1202. https://doi.org/10.1111/acer.12737

    Article  PubMed  PubMed Central  Google Scholar 

  8. Courtney KE, Ray LA (2014) Subjective responses to alcohol in the lab predict neural responses to alcohol cues. J Stud Alcoh Drugs 75(1):124–135. https://doi.org/10.15288/jsad.2014.75.124

    Article  Google Scholar 

  9. King AC, Houle T, Wit H, Holdstock L, Schuster A (2002) Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res 26(6):827–835. https://doi.org/10.1111/j.1530-0277.2002.tb02611.x

    Article  CAS  PubMed  Google Scholar 

  10. King AC, de Wit H, McNamara PJ, Cao D (2011) Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry 68(4):389. https://doi.org/10.1001/archgenpsychiatry.2011.26

    Article  PubMed  PubMed Central  Google Scholar 

  11. King AC, McNamara PJ, Hasin DS, Cao D (2014) Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. Biol Psychiatry 75(10):798–806. https://doi.org/10.1016/j.biopsych.2013.08.001

    Article  PubMed  Google Scholar 

  12. King AC, Hasin D, O’Connor SJ, McNamara PJ, Cao D (2016) A prospective 5-year re-examination of alcohol response in heavy drinkers progressing in alcohol use disorder. Biol Psychiatry 79(6):489–498. https://doi.org/10.1016/j.biopsych.2015.05.007

    Article  PubMed  Google Scholar 

  13. King AC, Vena A, Howe MM, Feather A, Cao D (2022) Haven’t lost the positive feeling: a dose-response, oral alcohol challenge study in drinkers with alcohol use disorder. Neuropsychopharmacology 47(11):1892–1900. https://doi.org/10.1038/s41386-022-01340-2

    Article  CAS  PubMed  Google Scholar 

  14. Schuckit MA (1988) A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. Arch Gen Psychiatry 45(3):211. https://doi.org/10.1001/archpsyc.1988.01800270019002

    Article  CAS  PubMed  Google Scholar 

  15. Schuckit MA (2000) Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol Alcohol 35(3):242–248. https://doi.org/10.1093/alcalc/35.3.242

    Article  CAS  PubMed  Google Scholar 

  16. Corbin WR, Gearhardt A, Fromme K (2008) Stimulant alcohol effects prime within session drinking behavior. Psychopharmacology 197(2):327–337. https://doi.org/10.1007/s00213-007-1039-x

    Article  CAS  PubMed  Google Scholar 

  17. Corbin WR, Scott C, Boyd SJ, Menary KR, Enders CK (2015) Contextual influences on subjective and behavioral responses to alcohol. Exp Clin Psychopharmacol 23(1):59–70. https://doi.org/10.1037/a0038760

    Article  PubMed  Google Scholar 

  18. Leeman RF, Berey BL, Frohe T, Rowland BHP, Martens MP, Fucito LM, Stellefson M, Nixon SJ, O’Malley SS (2022) A combined laboratory and field test of a smartphone breath alcohol device and blood alcohol concentration estimator to facilitate moderate drinking among young adults. Psychol Addict Behav 36(6):710–723. https://doi.org/10.1037/adb0000780

    Article  PubMed  Google Scholar 

  19. Davidson D, Palfai T, Bird C, Swift R (1999) Effects of naltrexone on alcohol self-administration in heavy drinkers. Alcohol Clin Exp Res 23(2):195–203. https://doi.org/10.1111/j.1530-0277.1999.tb04099.x

    Article  CAS  PubMed  Google Scholar 

  20. Leeman RF, Corbin WR, Nogueira C, Krishnan-Sarin S, Potenza MN, O’Malley SS (2013) A human alcohol self-administration paradigm to model individual differences in impaired control over alcohol use. Exp Clin Psychopharmacol 21(4):303–314. https://doi.org/10.1037/a0033438

    Article  PubMed  PubMed Central  Google Scholar 

  21. Leeman RF, Nogueira C, Wiers RW, Cousijn J, Serafini K, DeMartini KS, Bargh JA, O’Malley SS (2018) A test of multisession automatic action tendency retraining to reduce alcohol consumption among young adults in the context of a human laboratory paradigm. Alcohol Clin Exp Res 42(4):803–814. https://doi.org/10.1111/acer.13613

    Article  PubMed  PubMed Central  Google Scholar 

  22. Weafer J, Fillmore MT (2013) Acute alcohol effects on attentional bias in heavy and moderate drinkers. Psychol Addict Behav 27(1):32–41. https://doi.org/10.1037/a0028991

    Article  PubMed  Google Scholar 

  23. Krishnan-Sarin S, O’Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH (2015) N-methyl-d-aspartate receptor antagonism has differential effects on alcohol craving and drinking in heavy drinkers. Alcohol Clin Exp Res 39(2):300–307. https://doi.org/10.1111/acer.12619

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Kerfoot K, Pittman B, Ralevski E, Limoncelli D, Koretski J, Newcomb J, Arias AJ, Petrakis IL (2013) Effects of family history of alcohol dependence on the subjective response to alcohol using the intravenous alcohol clamp. Alcohol Clin Exp Res 37(12):2011–2018. https://doi.org/10.1111/acer.12199

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Cronce JM, Corbin WR (2010) Effects of alcohol and initial gambling outcomes on within-session gambling behavior. Exp Clin Psychopharmacol 18(2):145–157. https://doi.org/10.1037/a0019114

    Article  PubMed  PubMed Central  Google Scholar 

  26. Sedman AJ, Wilkinson PK, Sakmar E, Weidler DJ, Wagner JG (1976) Food effects on absorption and metabolism of alcohol. J Stud Alcohol 37(9):1197–1214. https://doi.org/10.15288/jsa.1976.37.1197

    Article  CAS  PubMed  Google Scholar 

  27. Sadler DW, Fox J (2011) Intra-individual and inter-individual variation in breath alcohol pharmacokinetics: the effect of food on absorption. Sci Justice 51(1):3–9. https://doi.org/10.1016/j.scijus.2010.10.003

    Article  CAS  PubMed  Google Scholar 

  28. Watson PE (1989) Total body water and blood alcohol levels: updating the fundamentals. In: Crow K, Batt R (eds) Human metabolism of alcohol, Pharmacokinetics, medicolegal aspects, and general interest, vol 1. CRC Press, Boca Raton, pp 41–58

    Google Scholar 

  29. Curtin JJ, Fairchild BA (2003) Alcohol and cognitive control: implications for regulation of behavior during response conflict. J Abnorm Psychol 112(3):424–436. https://doi.org/10.1037/0021-843x.112.3.424

    Article  PubMed  Google Scholar 

  30. Jatlow PI, Agro A, Wu R, Nadim H, Toll BA, Ralevski E, Nogueira C, Shi J, Dziura JD, Petrakis IL, O’Malley SS (2014) Ethyl glucuronide and ethyl sulfate assays in clinical trials, interpretation, and limitations: results of a dose ranging alcohol challenge study and 2 clinical trials. Alcohol Clin Exp Res 38(7):2056–2065. https://doi.org/10.1111/acer.12407

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Amlung M, McCarty KN, Morris DH, Tsai CL, McCarthy DM (2015) Increased behavioral economic demand and craving for alcohol following a laboratory alcohol challenge. Addiction 110(9):1421–1428. https://doi.org/10.1111/add.12897

    Article  PubMed  PubMed Central  Google Scholar 

  32. Dubowski KM (1985) Absorption, distribution and elimination of alcohol: highway safety aspects. J Stud Alcoh Suppl s10:98–108. https://doi.org/10.15288/jsas.1985.s10.98

    Article  Google Scholar 

  33. Whitfield JB, Martin NG (1994) Alcohol consumption and alcohol pharmacokinetics: interactions within the normal population. Alcohol Clin Exp Res 18(2):238–243. https://doi.org/10.1111/j.1530-0277.1994.tb00007.x

    Article  CAS  PubMed  Google Scholar 

  34. Jones AW (2010) Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework. Forensic Sci Int 200(1–3):1–20. https://doi.org/10.1016/j.forsciint.2010.02.021

    Article  CAS  PubMed  Google Scholar 

  35. Posner K, Brown GK, Stanley B, Brent DA, Yershova KV, Oquendo MA, Currier GW, Melvin GA, Greenhill L, Shen S, Mann JJ (2011) The Columbia–suicide severity rating scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatr 168(12):1266–1277. https://doi.org/10.1176/appi.ajp.2011.10111704

    Article  PubMed  Google Scholar 

  36. Johnson BA, Ait-Daoud N, Roache JD (2005) The combine SAFTEE: a structured instrument for collecting adverse events adapted for clinical studies in the alcoholism field. J Stud Alcoh Suppl s15:157–167. https://doi.org/10.15288/jsas.2005.s15.157

    Article  Google Scholar 

  37. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the biphasic alcohol effects scale. Alcohol Clin Exp Res 17(1):140–146. https://doi.org/10.1111/j.1530-0277.1993.tb00739.x

    Article  CAS  PubMed  Google Scholar 

  38. Morean ME, Corbin WR, Treat TA (2013) The subjective effects of alcohol scale: development and psychometric evaluation of a novel assessment tool for measuring subjective response to alcohol. Psychol Assess 25(3):780–795. https://doi.org/10.1037/a0032542

    Article  PubMed  Google Scholar 

  39. Corbin WR, Cronce JM (2007) Alcohol effects on behavioral control: the impact of likelihood and magnitude of negative consequences. Alcohol Clin Exp Res 31(6):955–964. https://doi.org/10.1111/j.1530-0277.2007.00389.x

    Article  PubMed  Google Scholar 

  40. Quinn PD, Fromme K (2016) Individual differences in subjective alcohol responses and alcohol-related disinhibition. Exp Clin Psychopharmacol 24(2):90–99. https://doi.org/10.1037/pha0000065

    Article  PubMed  PubMed Central  Google Scholar 

  41. Conrod PJ, Peterson JB, Pihl RO, Mankowski S (1997) Biphasic effects of alcohol on heart rate are influenced by alcoholic family history and rate of alcohol ingestion. Alcohol Clin Exp Res 21(1):140–149. https://doi.org/10.1111/j.1530-0277.1997.tb03742.x

    Article  CAS  PubMed  Google Scholar 

  42. Drobes DJ, Anton RF, Thomas SE, Voronin K (2004) Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers. Alcohol Clin Exp Res 28(9):1362–1370. https://doi.org/10.1097/01.alc.0000139704.88862.01

    Article  CAS  PubMed  Google Scholar 

  43. Ralevski E, Gueorguieva R, Limoncelli DD, Husain R, Serrita Jane J, Petrakis I (2006) Gelatin “shots” as a new method for alcohol administration in a laboratory setting. Alcohol Clin Exp Res 30(3):473–479. https://doi.org/10.1111/j.1530-0277.2006.00064.x

    Article  PubMed  Google Scholar 

  44. Keane TM, Lisman SA, Kreutzer J (1980) Alcoholic beverages and their placebos: an empirical evaluation of expectancies. Addict Behav 5(4):313–328. https://doi.org/10.1016/0306-4603(80)90005-2

    Article  CAS  PubMed  Google Scholar 

  45. Rohsenow DJ, Marlatt G (1981) The balanced placebo design: methodological considerations. Addict Behav 6(2):107–122. https://doi.org/10.1016/0306-4603(81)90003-4

    Article  CAS  PubMed  Google Scholar 

  46. Vena A, Howe M, Fridberg D, Cao D, King AC (2020) The feasibility, tolerability, and safety of administering a very high alcohol dose to drinkers with alcohol use disorder. Alcohol Clin Exp Res 44(12):2588–2597

    Article  PubMed  PubMed Central  Google Scholar 

  47. Morean ME, Corbin WR (2010) Subjective response to alcohol: a critical review of the literature. Alcohol Clin Exp Res 34(3):385–395. https://doi.org/10.1111/j.1530-0277.2009.01103.x

    Article  PubMed  Google Scholar 

  48. Shannon EE, Staniforth ER, McNamara J, Bernosky-Smith KA, Liguori A (2011) Response inhibition impairments predict alcohol-induced sedation. Alcohol Alcohol 46(1):33–38. https://doi.org/10.1093/alcalc/agq080

    Article  CAS  PubMed  Google Scholar 

  49. Aston ER, Shannon EE, Liguori A (2014) Anxiety, sedation, and simulated driving in binge drinkers. Psychol Addict Behav 28(2):359–366. https://doi.org/10.1037/a0036511

    Article  PubMed  PubMed Central  Google Scholar 

  50. Weafer J, Fillmore MT (2012) Comparison of alcohol impairment of behavioral and attentional inhibition. Drug Alcohol Depend 126(1–2):176–182. https://doi.org/10.1016/j.drugalcdep.2012.05.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Weafer J, Phan KL, de Wit H (2020) Poor inhibitory control is associated with greater stimulation and less sedation following alcohol. Psychopharmacology 237(3):825–832. https://doi.org/10.1007/s00213-019-05420-y

    Article  CAS  PubMed  Google Scholar 

  52. Weafer J, Fillmore MT (2015) Alcohol-related cues potentiate alcohol impairment of behavioral control in drinkers. Psychol Addict Behav 29(2):290–299. https://doi.org/10.1037/adb0000013

    Article  PubMed  Google Scholar 

  53. Gilbertson R, Ceballos NA, Prather R, Nixon SJ (2009) Effects of acute alcohol consumption in older and younger adults: perceived impairment versus psychomotor performance. J Stud Alcoh Drugs 70(2):242–252. https://doi.org/10.15288/jsad.2009.70.242

    Article  Google Scholar 

  54. Bernstein MH, Wood MD, Colby SM (2016) A new paradigm for credibly administering placebo alcohol to underage drinkers. Addict Behav 52:22–27. https://doi.org/10.1016/j.addbeh.2015.08.004

    Article  PubMed  Google Scholar 

  55. Schlauch RC, Waesche MC, Riccardi CJ, Donohue KF, Blagg CO, Christensen RL, Lang AR (2010) A meta-analysis of the effectiveness of placebo manipulations in alcohol-challenge studies. Psychol Addict Behav 24(2):239–253. https://doi.org/10.1037/a0017709

    Article  PubMed  Google Scholar 

  56. Testa M, Fillmore MT, Norris J, Abbey A, Curtin JJ, Leonard KE, Mariano KA, Thomas MC, Nomensen KJ, George WH, VanZile-Tamsen C, Livingston JA, Saenz C, Buck PO, Zawacki T, Parkhill MR, Jacques AJ, Hayman LW (2006) Understanding alcohol expectancy effects: revisiting the placebo condition. Alcohol Clin Exp Res 30(2):339–348. https://doi.org/10.1111/j.1530-0277.2006.00039.x

    Article  PubMed  PubMed Central  Google Scholar 

  57. Bowdring MA, Sayette MA (2021) The effect of alcohol on mood among males drinking with a platonic friend. Alcohol Clin Exp Res 45(10):2160–2166. https://doi.org/10.1111/acer.14682

    Article  PubMed  Google Scholar 

  58. Bates ME, Mun E, Buckman JF, Vaschillo E, Vaschillo B, Lehrer P, Udo T, Lesnewich LM (2020) Getting to the heart of low sensitivity to alcohol: context moderates low cardiovascular response to alcohol in persons with a family history of alcohol use disorder. Alcohol Clin Exp Res 44(3):589–599. https://doi.org/10.1111/acer.14293

    Article  PubMed  PubMed Central  Google Scholar 

  59. Korucuoglu O, Sher KJ, Wood PK, Saults JS, Altamirano L, Miyake A, Bartholow BD (2017) Acute alcohol effects on set-shifting and its moderation by baseline individual differences: a latent variable analysis. Addiction 112(3):442–453. https://doi.org/10.1111/add.13684

    Article  PubMed  Google Scholar 

  60. Conrad M, McNamara P, King A (2012) Alternative substance paradigm: effectiveness of beverage blinding and effects on acute alcohol responses. Exp Clin Psychopharmacol 20(5):382–389. https://doi.org/10.1037/a0029261

    Article  PubMed  PubMed Central  Google Scholar 

  61. National Advisory Council on Alcohol Abuse and Alcoholism (NIAAA) (2005) National Advisory Council on Alcohol Abuse and Alcoholism—recommended council guidelines on ethyl alcohol administration in human experimentation, revised May 2005. NIAAA, Bethesda

    Google Scholar 

  62. Schuckit MA, Gold EO (1988) A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. Arch Gen Psychiatry 45(3):211. https://doi.org/10.1001/archpsyc.1988.01800270019002

    Article  CAS  PubMed  Google Scholar 

  63. Babor TF, Mendelson JH, Greenberg I, Kuehnle J (1978) Experimental analysis of the “happy hour”: effects of purchase price on alcohol consumption. Psychopharmacology 58(1):35–41. https://doi.org/10.1007/bf00426787

    Article  CAS  PubMed  Google Scholar 

  64. Van Reen E, Tarokh L, Rupp TL, Seifer R, Carskadon MA (2011) Does timing of alcohol administration affect sleep? Sleep 34(2):195–205. https://doi.org/10.1093/sleep/34.2.195

    Article  PubMed  PubMed Central  Google Scholar 

  65. Roehrs T, Zwyghuizen-Doorenbos A, Knox M, Moskowitz H, Roth T (1992) Sedating effects of ethanol and time of drinking. Alcohol Clin Exp Res 16(3):553–557. https://doi.org/10.1111/j.1530-0277.1992.tb01416.x

    Article  CAS  PubMed  Google Scholar 

  66. Jones A, Button E, Rose AK, Robinson E, Christiansen P, Di Lemma L, Field M (2016) The ad-libitum alcohol ‘taste test’: secondary analyses of potential confounds and construct validity. Psychopharmacology 233(5):917–924. https://doi.org/10.1007/s00213-015-4171-z

    Article  CAS  PubMed  Google Scholar 

  67. Meegahapola L, Labhart F, Phan TT, Gatica-Perez D (2021) Examining the social context of alcohol drinking in young adults with smartphone sensing. Proc ACM Interact Mob Wearable Ubiquit Technol 5(3):1–26. https://doi.org/10.1145/3478126

    Article  Google Scholar 

  68. Stanesby O, Labhart F, Dietze P, Wright CJC, Kuntsche E (2019) The contexts of heavy drinking: a systematic review of the combinations of context-related factors associated with heavy drinking occasions. PLoS One 14(7):e0218465. https://doi.org/10.1371/journal.pone.0218465

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Ramirez JJ, Monti PM, Colwill RM (2015) Alcohol-cue exposure effects on craving and attentional bias in underage college-student drinkers. Psychol Addict Behav 29(2):317–322. https://doi.org/10.1037/adb0000028

    Article  PubMed  Google Scholar 

  70. Waddell JT, Corbin WR, Marohnic SD (2021) Putting things in context: longitudinal relations between drinking contexts, drinking motives, and negative alcohol consequences. Psychol Addict Behav 35(2):148–159. https://doi.org/10.1037/adb0000653

    Article  PubMed  Google Scholar 

  71. Larsen H, Engels RC, Souren PM, Granic I, Overbeek G (2010) Peer influence in a micro-perspective: imitation of alcoholic and non-alcoholic beverages. Addict Behav 35(1):49–52. https://doi.org/10.1016/j.addbeh.2009.08.002

    Article  PubMed  Google Scholar 

  72. Friedman LM, Furberg CD, DeMets DL (2010) Participant adherence. In: Fundamentals of clinical trials, pp 251–268. https://doi.org/10.1007/978-1-4419-1586-3_14

    Chapter  Google Scholar 

  73. Wang Y, Chen X, Hahn JA, Brumback B, Zhou Z, Miguez MJ, Cook RL (2018) Phosphatidylethanol in comparison to self-reported alcohol consumption among HIV-infected women in a randomized controlled trial of naltrexone for reducing hazardous drinking. Alcohol. Clin Exp Res 42(1):128–134. https://doi.org/10.1111/acer.13540

    Article  CAS  PubMed  Google Scholar 

  74. Roese NJ, Jamieson DW (1993) Twenty years of bogus pipeline research: a critical review and meta-analysis. Psychol Bull 114:363–375

    Article  Google Scholar 

  75. Fromme K, Stroot E, Kaplan D (1993) Comprehensive effects of alcohol: development and psychometric assessment of a new expectancy questionnaire. Psychol Assess 5:19–26

    Article  Google Scholar 

  76. Rueger SY, McNamara PJ, King AC (2009) Expanding the utility of the biphasic alcohol effects scale (BAES) and initial psychometric support for the brief-BAES (B-BAES). Alcohol Clin Exp Res 33(5):916–924

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Johanson CE, Uhlenhuth EH (1980) Drug preference and mood in humans: diazepam. Psychopharmacology 71(3):269–273. https://doi.org/10.1007/bf00433061

    Article  CAS  PubMed  Google Scholar 

  78. Morean ME, de Wit H, King AC, Sofuoglu M, Rueger SY, O’Malley SS (2012) The drug effects questionnaire: psychometric support across three drug types. Psychopharmacology 227(1):177–192. https://doi.org/10.1007/s00213-012-2954-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Haertzen CA, Hickey JE (1987) Addiction research center inventory (ARCI): measurement of euphoria and other drug effects. In: Methods of assessing the reinforcing properties of abused drugs, pp 489–524. https://doi.org/10.1007/978-1-4612-4812-5_24

    Chapter  Google Scholar 

  80. Martin WR, Sloan JW, Sapira JD, Jasinski DR (1971) Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Therap 12(2 part1):245–258. https://doi.org/10.1002/cpt1971122part1245

    Article  CAS  Google Scholar 

  81. Dollinger SJ, Malmquist D (2009) Reliability and validity of single-item self-reports: with special relevance to college students’ alcohol use, religiosity, study, and social life. J Gen Psychol 136(3):231–242. https://doi.org/10.3200/genp.136.3.231-242

    Article  PubMed  Google Scholar 

  82. Bohn MJ, Krahn DD, Staehler BA (1995) Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcohol Clin Exp Res 19(3):600–606. https://doi.org/10.1111/j.1530-0277.1995.tb01554.x

    Article  CAS  PubMed  Google Scholar 

  83. MacKillop J (2006) Factor structure of the alcohol urge questionnaire under neutral conditions and during a cue-elicited urge state. Alcohol Clin Exp Res 30(8):1315–1321. https://doi.org/10.1111/j.1530-0277.2006.00159.x

    Article  PubMed  Google Scholar 

  84. Love A, James D, Willner P (1998) A comparison of two alcohol craving questionnaires. Addiction 93(7):1091–1102. https://doi.org/10.1046/j.1360-0443.1998.937109113.x

    Article  CAS  PubMed  Google Scholar 

  85. Leeman RF, Corbin WR, Fromme K (2009) Craving predicts within session drinking behavior following placebo. Personal Individ Differ 46(7):693–698. https://doi.org/10.1016/j.paid.2009.01.024

    Article  Google Scholar 

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Authors and Affiliations

  1. Center for Alcohol and Addiction Studies, School of Public Health, Brown University, Providence, RI, USA

    Benjamin L. Berey

  2. Department of Health Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA

    Bailee R. Wilson & Robert F. Leeman

  3. Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA

    Jessica Weafer

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  2. Bailee R. Wilson
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  3. Jessica Weafer
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  4. Robert F. Leeman
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Correspondence to Robert F. Leeman .

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Editors and Affiliations

  1. Department of Psychology, Indiana University – Purdue University, Indianapolis, IN, USA

    Melissa A. Cyders

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Berey, B.L., Wilson, B.R., Weafer, J., Leeman, R.F. (2023). Details in Conducting Human Laboratory Alcohol Administration and Self-Administration Experiments to Assess Subjective Response and Craving for Alcohol. In: Cyders, M.A. (eds) Translational Research Methods for Alcohol Use Disorders. Neuromethods, vol 201. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3267-3_9

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  • DOI: https://doi.org/10.1007/978-1-0716-3267-3_9

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3266-6

  • Online ISBN: 978-1-0716-3267-3

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