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Vaccine Design: An Introduction

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Computational Vaccine Design

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2673))

Abstract

Vaccines are the most successful and cost-effective medical interventions available to fight infectious diseases. They consist of biological preparations that are capable of stimulating the immune system to confer protective immunity against a particular harmful pathogen/agent. Vaccine design and development have evolved through the years. Early vaccines were obtained with little implementation of technology and in the absence of fundamental knowledge, representing a pure feat of human ingenuity. In contrast, modern vaccine development takes advantage of advances in technology and in our enhanced understanding of the immune system and host-pathogen interactions. Moreover, vaccine design has found novel applications beyond the prophylactic arena and there is an increasing interest in designing vaccines to treat human ailments like cancer and chronic inflammatory diseases. In this chapter, we focus on prophylactic vaccines against infectious diseases, providing an overview on immunology principles underlying immunization and on how vaccines work and are designed.

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Acknowledgment

We wish to thank Esther M. Lafuente and Hector F. Pelaez for critical reading and valuable comments.

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Authors and Affiliations

  1. School of Medicine, Department of Immunology, Complutense University of Madrid, Madrid, Spain

    Tara Fiyouzi & Pedro A. Reche

Authors
  1. Tara Fiyouzi
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  2. Pedro A. Reche
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Corresponding author

Correspondence to Pedro A. Reche .

Editor information

Editors and Affiliations

  1. School of Medicine, Department of Immunology, Complutense University of Madrid, Madrid, Spain

    Pedro A. Reche

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Fiyouzi, T., Reche, P.A. (2023). Vaccine Design: An Introduction. In: Reche, P.A. (eds) Computational Vaccine Design. Methods in Molecular Biology, vol 2673. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3239-0_1

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  • DOI: https://doi.org/10.1007/978-1-0716-3239-0_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3238-3

  • Online ISBN: 978-1-0716-3239-0

  • eBook Packages: Springer Protocols

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