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Magnetic Resonance Spectroscopy

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Computational Neuroscience

Part of the book series: Neuromethods ((NM,volume 199))

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Abstract

Magnetic resonance spectroscopy (MRS) is a completely noninvasive technique which allows the detection of brain metabolites’ concentrations in vivo. Brain metabolites are involved in energy processes, neuronal and membrane health, and in neurotransmission. The possibility of identifying changes in their concentration may open the way to early diagnosis and treatment evaluation in various pathologies.

In this chapter, the main principles behind brain MRS are briefly discussed, together with an overview of the primary clinical applications. Moreover, some concepts about data acquisition and processing are discussed, with the aim of facilitating MRS spectra analysis and interpretation.

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Acknowledgments

This work was partially funded by grants from the Italian Ministry of Health.

(RF-2019-12371349), Fondazione Cariplo (2019-3416), and ERA-NET NEURON (JTC2018: UNMET).

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Authors and Affiliations

  1. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

    Letizia Squarcina & Paolo Brambilla

  2. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy

    Paolo Brambilla

Authors
  1. Letizia Squarcina
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  2. Paolo Brambilla
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Corresponding author

Correspondence to Paolo Brambilla .

Editor information

Editors and Affiliations

  1. Division of Translational Neuroscience, Medical University of Plovdiv, Plovdiv, Bulgaria

    Drozdstoy Stoyanov

  2. University of Lausanne, CHUV, Lausanne, Switzerland

    Bogdan Draganski

  3. Pathophysiology and Transplantation, University of Milan, Milan, Italy

    Paolo Brambilla

  4. Cognitive & Affective Neuroscience Unit, University of Vienna, Vienna, Austria

    Claus Lamm

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Squarcina, L., Brambilla, P. (2023). Magnetic Resonance Spectroscopy. In: Stoyanov, D., Draganski, B., Brambilla, P., Lamm, C. (eds) Computational Neuroscience. Neuromethods, vol 199. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3230-7_12

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  • DOI: https://doi.org/10.1007/978-1-0716-3230-7_12

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3229-1

  • Online ISBN: 978-1-0716-3230-7

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