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Rodent Stroke Models to Study Functional Recovery and Neural Repair

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Neural Repair

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2616))

Abstract

Rodent ischemic stroke models are essential research tools for studying this highly prevalent disease and represent a critical element in the translational pipeline for development of new therapies. The majority of ischemic stroke models have been developed to study the acute phase of the disease and neuroprotective strategies, but a subset of models is better suited for studying stroke recovery. Each model therefore has characteristics that lend itself to certain types of investigations and outcome measures, and it is important to consider both explicit and implicit details when designing experiments that utilize each model. The following chapter briefly summarizes the known aspects of the main rodent stroke models with emphasis on their clinical relevance and suitability for studying recovery and neural repair following stroke.

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Author information

Authors and Affiliations

  1. Department of Neurology, Department of Neuroscience, The University of Kentucky, Lexington, KY, USA

    Daimen R. S. Britsch & Ann M. Stowe

  2. Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA

    Nausheen Syeara & Vardan T. Karamyan

  3. Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA

    Vardan T. Karamyan

Authors
  1. Daimen R. S. Britsch
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  2. Nausheen Syeara
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  3. Ann M. Stowe
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  4. Vardan T. Karamyan
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Corresponding author

Correspondence to Vardan T. Karamyan .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA

    Vardan T. Karamyan

  2. Department of Neurology, Department of Neuroscience, The University of Kentucky, Lexington, KY, USA

    Ann M. Stowe

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Britsch, D.R.S., Syeara, N., Stowe, A.M., Karamyan, V.T. (2023). Rodent Stroke Models to Study Functional Recovery and Neural Repair. In: Karamyan, V.T., Stowe, A.M. (eds) Neural Repair. Methods in Molecular Biology, vol 2616. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2926-0_1

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  • DOI: https://doi.org/10.1007/978-1-0716-2926-0_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2925-3

  • Online ISBN: 978-1-0716-2926-0

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