Abstract
High-throughput sequencing (HTS) technologies have contributed to expand current knowledge of the biology of complex diseases, including nonalcoholic fatty liver disease (NAFLD). Genome-wide association studies, whole exome sequencing, and sequencing of entire genes are used to identify variants and/or mutations that predispose to the disease pathogenesis. Here, we present a tutorial that may guide readers to manage high volume of genetics data in the context of Next-Generation Sequencing (NGS) studies.
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Acknowledgments
This study was partially supported by Grants PICT 2018-0620, PICT 2018-0889, and PICT 2016-0135 (Agencia Nacional de Promoción Científica y Tecnológica, FONCyT), Proyectos Unidades Ejecutoras 2017, PUE 0055(CONICET).
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Salatino, A., Sookoian, S., Pirola, C.J. (2022). Computational Pipeline for Next-Generation Sequencing (NGS) Studies in Genetics of NASH. In: Sarkar, D. (eds) Non-Alcoholic Steatohepatitis. Methods in Molecular Biology, vol 2455. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2128-8_16
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DOI: https://doi.org/10.1007/978-1-0716-2128-8_16
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