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Behavioral Paradigms for Assessing Cognitive Functions in the Chronic Social Defeat Stress Model of Depression

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Translational Research Methods for Major Depressive Disorder

Part of the book series: Neuromethods ((NM,volume 179))

Abstract

Depression is a debilitating mental disorder that affects hundreds of millions of individuals worldwide. Also referred to as major depressive disorder or clinical depression, this disorder is mainly characterized by a persistent feeling of sadness and a loss of interest. There is also substantial evidence showing that depression is frequently accompanied by deficits in cognitive functions, including working memory, learning, and executive functions. Given the high prevalence of poor cognitive functioning in depressed patients, several studies have investigated the link between the two using animal models of depression. Despite significant progress in research, more work is still needed to better understand the association between cognitive impairment and depression. Results of such studies could lead to a better understanding of the pathophysiology of depression and could ultimately pave the way toward new and more efficient therapeutic approaches. In this chapter, we describe some of the behavioral techniques used to assess cognitive function in the chronic social defeat stress mice model, a well-established model of depression. Focus is given on the spontaneous alternation T-maze test and the Morris water maze test.

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Authors and Affiliations

  1. Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon

    Marc Fakhoury & Sama F. Sleiman

  2. Department of Forensic Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany

    Michael Fritz

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  1. Marc Fakhoury
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  2. Michael Fritz
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  3. Sama F. Sleiman
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  1. Department of Psychiatry, Korea University Ansan Hospital, Ansan, Korea (Republic of)

    Yong-Ku Kim

  2. Deptartment of Speech Therapy, Isfahan University of Medical Sciences, Isfahan, Iran

    Meysam Amidfar

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Fakhoury, M., Fritz, M., Sleiman, S.F. (2022). Behavioral Paradigms for Assessing Cognitive Functions in the Chronic Social Defeat Stress Model of Depression. In: Kim, YK., Amidfar, M. (eds) Translational Research Methods for Major Depressive Disorder. Neuromethods, vol 179. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2083-0_7

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  • DOI: https://doi.org/10.1007/978-1-0716-2083-0_7

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