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Magnetic Resonance Imaging as a Translational Research Tool for Major Depression

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Translational Research Methods for Major Depressive Disorder

Part of the book series: Neuromethods ((NM,volume 179))

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Abstract

Major depressive disorder (MDD, also known as major depression) is a major health issue in the modern society. The translational research in MDD can help us understand the pathophysiology of MDD. In the neuroimaging field, magnetic resonance imaging (MRI) will be a major tool for the translational research. In this chapter, several methods of MRI category will be addressed, such as the task functional MRI (T-FMRI), resting-state functional MRI (Rs-FMRI), diffusion tensor imaging (DTI), diffusion spectrum imaging (DSI), voxel-based morphometry (VBM), and magnetic resonance spectroscopy (MRS). The theory, preparation, and details of these MRI-related methods will be addressed in this review article. Basically, these methods can compensate each other in the representations of biological meaning. The functional characteristics of MRS, T-FMRI, and Rs-FMRI can enrich the functional fundamentals of structural characteristics of DTI and VBM. Therefore, theoretically, the “multimodal MRI” methods will be a future trend of neuroimaging research to help us make a sophisticated differentiation of pathophysiology subtype of MDD.

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Authors and Affiliations

  1. Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan

    Chien-Han Lai

  2. PhD Psychiatry & Neuroscience Clinic, Taoyuan, Taiwan

    Chien-Han Lai

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  1. Chien-Han Lai
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Editors and Affiliations

  1. Department of Psychiatry, Korea University Ansan Hospital, Ansan, Korea (Republic of)

    Yong-Ku Kim

  2. Deptartment of Speech Therapy, Isfahan University of Medical Sciences, Isfahan, Iran

    Meysam Amidfar

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Lai, CH. (2022). Magnetic Resonance Imaging as a Translational Research Tool for Major Depression. In: Kim, YK., Amidfar, M. (eds) Translational Research Methods for Major Depressive Disorder. Neuromethods, vol 179. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2083-0_12

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  • DOI: https://doi.org/10.1007/978-1-0716-2083-0_12

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2082-3

  • Online ISBN: 978-1-0716-2083-0

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