Abstract
Protein misfolding diseases, like Alzheimer’s, Parkinson’s, and Huntington’s disease, are associated with misfolded protein aggregation. Alzheimer’s disease is related to a progressive neuronal death induced by small amyloid β oligomers. Here, we describe the procedure to prepare and identify different types of small toxic amyloid β oligomers by atomic force microscopy (AFM).
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Acknowledgments
This work was supported by receiving funding from the Polish National Science Centre, grant No. OPUS12 2016/23B/ST4/02791, awarded to P.P. The research activity of D.M. was supported by funds from the European Union Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement No. 711859, and the Polish Ministry of Science and Higher Education for the implementation of an international co-financed project in the years 2017–2021. J.L. was financially supported by Discovery grant from the National Sciences and Engineering Research Council of Canada (RG-03958).
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Mrdenovic, D., Lipkowski, J., Pieta, P. (2022). Analyzing Morphological Properties of Early-Stage Toxic Amyloid β Oligomers by Atomic Force Microscopy. In: Cranfield, C.G. (eds) Membrane Lipids. Methods in Molecular Biology, vol 2402. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1843-1_18
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DOI: https://doi.org/10.1007/978-1-0716-1843-1_18
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