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Electrochemistry Coupling Localized Surface Plasmon Resonance for Biochemical Detection

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Biomedical Engineering Technologies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2393))

Abstract

Localized surface plasmon resonance (LSPR) associated with metal nanostructures has developed into highly useful sensor techniques. LSPR spectroscopy often shows absorption peaks which could be used for biomedical detection. Here we report nanoplasmonic sensors using LSPR on nanostructures such as nanoparticles, nanocups, and nanocones to recognize biomolecular. These sensors can be modified for quantitative detection of explosives and evaluation of enzymatic activity. Electrochemical LSPR sensors can also be designed by coupling electrochemistry and LSPR spectroscopy measurements for biochemical detection. Multiple sensing information can be obtained and electrochemical LSPR property can be investigated for biosensors. In some applications, the electrochemical LSPR biosensor can be used to quantify heavy metal ions, neurotransmitters, and sialic acid. The biosensors exhibit better performance than those of conventional optical LSPR measurements. With multitransducers, the nanoplasmonic biosensor can provide a promising approach for biochemical detection in environmental monitoring, healthcare diagnostics, and food quality control.

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Acknowledgments

This work was supported by National Key Research and Development Program (Grant No. 2018YFC1707701), the National Natural Science Foundation of China (Grant No. 81801793, 31671007), the China Postdoctoral Science Foundation (Grant No. 2018M630677, 2019T120518).

Author information

Authors and Affiliations

  1. Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, P. R. China

    Zetao Chen, Yanli Lu, Qingqing Zhang, Diming Zhang, Shuang Li & Qingjun Liu

Authors
  1. Zetao Chen
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  2. Yanli Lu
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  3. Qingqing Zhang
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  4. Diming Zhang
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  5. Shuang Li
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  6. Qingjun Liu
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Corresponding author

Correspondence to Qingjun Liu .

Editor information

Editors and Affiliations

  1. Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD, USA

    Miguel R. Ossandon

  2. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA

    Houston Baker

  3. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA

    Avraham Rasooly

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Chen, Z., Lu, Y., Zhang, Q., Zhang, D., Li, S., Liu, Q. (2022). Electrochemistry Coupling Localized Surface Plasmon Resonance for Biochemical Detection. In: Ossandon, M.R., Baker, H., Rasooly, A. (eds) Biomedical Engineering Technologies. Methods in Molecular Biology, vol 2393. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1803-5_2

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  • DOI: https://doi.org/10.1007/978-1-0716-1803-5_2

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1802-8

  • Online ISBN: 978-1-0716-1803-5

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