Abstract
Caenorhabditis elegans is a highly versatile model system, intensively used for functional, genetic, cytometric, and integrative studies. Due to its simplicity and large muscle cell number, C. elegans has frequently been used to study mitochondrial deficiencies caused by disease or drug toxicity. Here we describe a robust and efficient method to visualize and quantify mitochondrial morphology in vivo. This method has many practical and technical advantages above traditional (manual) methods and provides a comprehensive analysis of mitochondrial morphology.
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de Boer, R., Smith, R.L., De Vos, W.H., Manders, E.M.M., van der Spek, H. (2021). In Vivo Visualization and Quantification of Mitochondrial Morphology in C. elegans . In: Weissig, V., Edeas, M. (eds) Mitochondrial Medicine . Methods in Molecular Biology, vol 2276. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-1266-8_29
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DOI: https://doi.org/10.1007/978-1-0716-1266-8_29
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