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Animal Models of Binge Eating: Hedonic Feeding and Alcohol Intake

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Animal Models of Eating Disorders

Part of the book series: Neuromethods ((NM,volume 161))

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Abstract

Binge eating is a behavioral component of some eating disorders associated with the development of obesity and associated metabolic pathologies. Over the past two decades, it has become increasingly clear that the intake of food and drugs is controlled by a shared set of neuronal circuitry. In this regard, the excessive food intake, present in binge eating, has been linked with development of addictive behavior. This chapter describes an animal model of fat bingeing in combination with assessment of alcohol intake, which enables investigators to measure the behavioral, physiologic, and genetic impacts of pathological feeding on substance abuse. This model of binge eating has been shown to reduce alcohol intake and alter anxiety-like behavior and central genetic changes linked with regulation of alcohol intake. Overall, these data support the hypothesis that some palatable food exposure may have the potential to alter the intake of drugs of abuse.

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References

  1. Overweight & Obesity Statistics | NIDDK (n.d.) Retrieved September 30, 2019, from National Institute of Diabetes and Digestive and Kidney Diseases website: https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity

  2. Brutman JN, Sirohi S, Davis JF (2019) Examining the impact of estrogen on binge feeding, food-motivated behavior, and body weight in female rats. Obesity (Silver Spring, MD) 27(10):1617–1626

    Article  CAS  Google Scholar 

  3. Sirohi S, Van Cleef A, Davis JF (2017) Patterned feeding induces neuroendocrine, behavioral and genetic changes that promote palatable food intake. Int J Obesity 41(3):412–419

    Article  CAS  Google Scholar 

  4. Hilbert A (2019) Binge-eating disorder. Psychiatr Clin North Amer 42(1):33–43

    Article  Google Scholar 

  5. Berkman ND et al (2015) Table 1, DSM-IV and DSM-5 diagnostic criteria for binge-eating disorder [Text]. Retrieved September 30, 2019, from https://www.ncbi.nlm.nih.gov/books/NBK338301/table/introduction.t1/

  6. Hudson JI et al (2007) The prevalence and correlates of eating disorders in the national comorbidity survey replication. Biol Psychiatr 61(3):348–358

    Article  Google Scholar 

  7. Baker JH et al (2010) Eating disorder symptomatology and substance use disorders: Prevalence and shared risk in a population based twin sample. Int J Eat Disord 43(7):648–658

    Article  Google Scholar 

  8. Holderness CC, Brooks-Gunn J, Warren MP (1994) Co-morbidity of eating disorders and substance abuse review of the literature. Int J Eat Disord 16(1):1–34

    Article  CAS  Google Scholar 

  9. Franko DL et al (2005) How do eating disorders and alcohol use disorder influence each other? Int J Eat Disord 38(3):200–207

    Article  Google Scholar 

  10. Udo T, Grilo CM (2019) Psychiatric and medical correlates of DSM-5 eating disorders in a nationally representative sample of adults in the United States. Int J Eat Disord 52(1):42–50

    Article  Google Scholar 

  11. Baker JH et al (2017) Shared familial risk between bulimic symptoms and alcohol involvement during adolescence. J Abnorm Psychol 126(5):506–518

    Article  Google Scholar 

  12. von Ranson KM, McGue M, Iacono WG (2003) Disordered eating and substance use in an epidemiological sample: II. Associations within families. Psychol Addict Behav 17(3):193–201

    Article  Google Scholar 

  13. Kaye WH et al (1996) Bulimia nervosa and substance dependence: association and family transmission. Alcohol Clin Exp Res 20(5):878–881

    Article  CAS  Google Scholar 

  14. Lilenfeld LR et al (1998) A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity. Arch Gen Psychiatry 55(7):603–610

    Article  CAS  Google Scholar 

  15. Kendler KS et al (1995) The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Arch Gen Psychiatry 52(5):374–383

    Article  CAS  Google Scholar 

  16. Bulik CM (1987) Drug and alcohol abuse by bulimic women and their families. Am J Psychiatry 144(12):1604–1606

    Article  CAS  Google Scholar 

  17. Sirohi S, Van Cleef A, Davis JF (2017) Binge-like intake of HFD attenuates alcohol intake in rats. Physiol Behav 178:187–195

    Article  CAS  Google Scholar 

  18. Corwin RLW, Babbs RK (2012) Rodent models of binge eating: are they models of addiction? ILAR J 53(1):23–34

    Article  CAS  Google Scholar 

  19. Perello M et al (2014) Considerations about rodent models of binge eating episodes. Front Psychol 5:372

    Article  Google Scholar 

  20. Wolfe BE et al (2009) Validity and utility of the current definition of binge eating. Int J Eat Disord 42(8):674–686

    Article  Google Scholar 

  21. Barson JR, Leibowitz SF (2016) Hypothalamic neuropeptide signaling in alcohol addiction. Prog Neuropsychopharmacol Biol Psychiatry 65:321–329

    Article  CAS  Google Scholar 

  22. Barson JR, Morganstern I, Leibowitz SF (2011) Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol. Physiol Behav 104(1):128–137

    Article  CAS  Google Scholar 

  23. Davis JF et al (2007) Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats. Physiol Behav 92(5):924–930

    Article  CAS  Google Scholar 

  24. Melendez RI, Middaugh LD, Kalivas PW (2006) Development of an alcohol deprivation and escalation effect in C57BL/6J mice. Alc Clin Exp Res 30(12):2017–2025

    Article  Google Scholar 

  25. Davis JF et al (2008) Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci 122(6):1257–1263

    Article  Google Scholar 

  26. Sirohi S, Van Cleef A, Davis JF (2017) Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats. Pharmacol Biochem Behav 153:105–115

    Article  CAS  Google Scholar 

  27. Avena NM, Rada P, Hoebel BG (2009) Sugar and fat bingeing have notable differences in addictive-like behavior. J Nutr 139(3):623–628

    Article  CAS  Google Scholar 

  28. Avena NM, Rada P, Hoebel BG (2008) Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 32(1):20–39

    Article  CAS  Google Scholar 

  29. Avena NM et al (2004) Sugar-dependent rats show enhanced intake of unsweetened ethanol. Alcohol 34(2–3):203–209

    Article  CAS  Google Scholar 

  30. Colantuoni C et al (2002) Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 10(6):478–488

    Article  CAS  Google Scholar 

  31. Langen B, Fink H (2004) Anxiety as a predictor of alcohol preference in rats? Prog Neuropsychopharmacol Biol Psychiatry 28(6):961–968

    Article  CAS  Google Scholar 

  32. Allan CA (1995) Alcohol problems and anxiety disorders–a critical review. Alcohol Alcohol 30(2):145–151

    CAS  PubMed  Google Scholar 

  33. Lejoyeux M et al (2000) Alcohol dependence among patients admitted to psychiatric emergency services. Gen Hosp Psychiatry 22(3):206–212

    Article  CAS  Google Scholar 

  34. Walf AA, Frye CA (2007) The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2(2):322–328

    Article  CAS  Google Scholar 

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Acknowledgments

This publication was made possible by funding, in part, by NIGMS-SCORE no. 1SC3GM127173-01A1 to SS.

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Authors and Affiliations

  1. Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, USA

    Julianna N. Brutman & Jon F. Davis

  2. Laboratory of Endocrine and Neuropsychiatric Disorders, Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA

    Sunil Sirohi

Authors
  1. Julianna N. Brutman
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  2. Sunil Sirohi
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  3. Jon F. Davis
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Corresponding author

Correspondence to Jon F. Davis .

Editor information

Editors and Affiliations

  1. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Nicole M. Avena

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Brutman, J.N., Sirohi, S., Davis, J.F. (2021). Animal Models of Binge Eating: Hedonic Feeding and Alcohol Intake. In: Avena, N.M. (eds) Animal Models of Eating Disorders. Neuromethods, vol 161. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0924-8_9

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  • DOI: https://doi.org/10.1007/978-1-0716-0924-8_9

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0923-1

  • Online ISBN: 978-1-0716-0924-8

  • eBook Packages: Springer Protocols

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