Abstract
Radiation therapy is a powerful tool in the treatment of primary and metastatic cancers of the brain. However, brain tissue tolerance is limited, and radiation doses must be tailored to minimize deleterious effects on the nervous system. Due to improved treatments, including radiotherapy techniques, many patients with brain tumors survive longer, but they experience late effects of radiotherapy, especially cognitive decline, for which no efficient treatment is currently available. Improving the prevention and treatment of radiation-induced neurological defects first needs to better characterize radiation injuries in brain cells and tissues. Rodent models have been widely used for this.
Here, observations from patients will be reviewed briefly as an introduction, mainly regarding clinical cognitive defects and anatomical alterations using magnetic resonance imaging (MRI). This limited descriptive clinical knowledge addresses many questions that arise in preclinical models regarding understanding the mechanism of radiation-induced brain dysfunction. From this perspective, we next present methods to characterize radiation-induced neurogenesis alterations in adult mice and then detail how MRI could be used as a powerful tool to explore these alterations.
Laura Mouton and Monica Ribeiro are co-first authors.
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Mouton, L. et al. (2021). Experimental and Preclinical Tools to Explore the Main Neurological Impacts of Brain Irradiation: Current Insights and Perspectives. In: Seano, G. (eds) Brain Tumors. Neuromethods, vol 158. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-0856-2_11
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