Abstract
Given the magnitude of chemicals that require ecotoxicity assessments for regulatory purposes, read-across allows for the filling in certain data requirements, such as endpoint estimation, screening and prioritization, and hazard identification, provided that they are justified and documented. In this chapter, we present a recompilation of recognized regulations and guidelines, as well as software and tools, used in grouping and read-across for ecotoxicology-related endpoints. Additionally, an exemplary read-across study for the bioconcentration factor prediction is included.
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Abbreviations
- ADI:
-
Applicability domain index
- BCF:
-
Bioconcentration factor
- CAS:
-
Chemical Abstracts Service
- ECETOC:
-
European Centre for Ecotoxicology and Toxicology of Chemicals
- ECHA:
-
European Chemicals Agency
- EFSA:
-
European Food Safety Authority
- EU:
-
European Union
- FDA:
-
Food and Drug Administration
- HPV:
-
High production volume
- KNN:
-
K-nearest neighbor
- LOAEL:
-
Lowest-observed-adverse-effect level
- NOAEL:
-
No-observed-adverse-effect level
- NTM:
-
Non-testing methods
- OECD:
-
Organisation for Economic Co-operation and Development
- PBT/vPvB:
-
Persistent, bioaccumulative, and toxic/very persistent and very bioaccumulative
- QSAR:
-
Quantitative structure-activity relationship
- REACH:
-
Registration, Evaluation, Authorisation and Restriction of Chemicals
- US EPA:
-
United States Environmental Protection Agency
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Tugcu, G., Önlü, S., Aydin, A., Saçan, M.T. (2020). Read-Across for Regulatory Ecotoxicology. In: Roy, K. (eds) Ecotoxicological QSARs. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0150-1_13
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DOI: https://doi.org/10.1007/978-1-0716-0150-1_13
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