Abstract
To date, several stem cell labeling protocols have been developed, contributing to a fast growing and promising field of stem cell imaging by MRI (magnetic resonance imaging). Most of these methods utilize iron oxide nanoparticles (MION, SPIO, USPIO, VSIOP) for cell labeling, which provide negative (dark) signal effects on T2-weighted MR images. The following protocol describes stem cell labeling techniques with commercially available gadolinium chelates, which provide positive contrast on T1-weighted MR images, which can be advantageous for specific applications.
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Nejadnik, H., Castillo, R., Daldrup-Link, H.E. (2013). Magnetic Resonance Imaging and Tracking of Stem Cells. In: Turksen, K. (eds) Imaging and Tracking Stem Cells. Methods in Molecular Biology, vol 1052. Humana Press, Totowa, NJ. https://doi.org/10.1007/7651_2013_16
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DOI: https://doi.org/10.1007/7651_2013_16
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-558-3
Online ISBN: 978-1-62703-559-0
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